Journal
NATURE GENETICS
Volume 45, Issue 4, Pages 415-421Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2568
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Funding
- National Human Genome Research Institute [U54HG003079]
- US National Institutes of Health [F32GM087919, T32HG00035, DE017911, R03NS078519, R01HG004694, GM079492, GM090049, RR014085, R37HD032443]
- National Science Foundation [MCB-0719558, IOS-0849569]
- New Hampshire Agricultural Experiment Station [2471]
- Charles Evans Research Award
- Wellcome Trust [WT095908, WT098051]
- Canadian Institutes of Health Research [MOP74667]
- Natural Sciences and Engineering Research Council of Canada [312221]
- [R24GM83982]
- MRC [MC_U117597141] Funding Source: UKRI
- Medical Research Council [MC_U117597141] Funding Source: researchfish
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0849569] Funding Source: National Science Foundation
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Lampreys are representatives of an ancient vertebrate lineage that diverged from our own similar to 500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome is uniquely poised to provide insight into the ancestry of vertebrate genomes and the underlying principles of vertebrate biology. Here, we present the first lamprey whole-genome sequence and assembly. We note challenges faced owing to its high content of repetitive elements and GC bases, as well as the absence of broad-scale sequence information from closely related species. Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages. Moreover, the results help define key evolutionary events within vertebrate lineages, including the origin of myelin-associated proteins and the development of appendages. The lamprey genome provides an important resource for reconstructing vertebrate origins and the evolutionary events that have shaped the genomes of extant organisms.
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