Journal
NATURE GENETICS
Volume 41, Issue 7, Pages 768-769Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng0709-768
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MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. a new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.
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