Article
Multidisciplinary Sciences
Alice Correa Silva-Sousa, Guido Artemio Maranon-Vasquez, Maria Bernadete Sasso Stuani, Peter Proff, Kesly Mary Ribeiro Andrades, Flares Baratto-Filho, Mirian Aiko Nakane Matsumoto, Eva Paddenberg, Erika Calvano Kuechler, Christian Kirschneck
Summary: This study found that genetic variants in the BMP pathway are associated with variations in the palatal rugae pattern in humans. Specific genetic variants were linked to the quantity, length, shape, unification, and predominant shape of the palatal rugae.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Marilyn D. Resh
Summary: This review discusses the role of Hedgehog acyltransferase (Hhat) in Hedgehog signaling, the importance of palmitoylation, and the potential involvement of Hhat in various cancers. Targeting hedgehog palmitoylation by inhibiting Hhat is considered a promising intervention in human disease.
Review
Oncology
Jian Yi Chai, Vaisnevee Sugumar, Ahmed F. Alshanon, Won Fen Wong, Shin Yee Fung, Chung Yeng Looi
Summary: The Hedgehog (Hh) signaling pathway plays a crucial role in cancer treatment, particularly in chemotherapy resistance. Understanding the mechanisms regulated by Hh signaling is essential for developing more effective treatment strategies in cancer therapy.
Article
Biochemistry & Molecular Biology
Yitian Luo, Guoyue Wan, Xiang Zhang, Xuan Zhou, Qiuwen Wang, Jialin Fan, Hongmin Cai, Liya Ma, Hailong Wu, Qianhui Qu, Yao Cong, Yun Zhao, Dianfan Li
Summary: The study reconstituted Patched (Ptc1) into lipid nanodiscs and found that Ptc1 can form dimers under different membrane curvatures, providing a plausible framework for Ptc1 clustering in highly curved caveolae.
Article
Cell Biology
Dominique Manikowski, Philipp Kastl, Sabine Schuermann, Kristina Ehring, Georg Steffes, Petra Jakobs, Kay Grobe
Summary: The study reveals that C-terminal cholesteroylation of Hedgehog is essential for early steps of production and maturation, but dispensable for signal reception at receiving cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A. Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D. Johnston, Claire E. Coupland, Jake L. Greenfield, Joshua Newington, Matthew J. Fuchter, Anthony I. Magee, Christian Siebold, Edward W. Tate
Summary: This study reports the rational development of a photochemical probe to investigate a novel small-molecule inhibitor binding site in the human MBOAT Hedgehog acyltransferase (HHAT), leading to the identification of the most potent HHAT inhibitor IMP-1575 to date. Through structure-activity relationship investigation and methods such as photocrosslinking, the study revealed the inhibition mechanism and small molecule binding site of HHAT, providing a strategy for mapping small molecule interaction sites in MBOATs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Agriculture, Dairy & Animal Science
Gabriela Fernandes Silva, Alexandra Rema, Silvia Teixeira, Maria dos Anjos Pires, Marian Taulescu, Irina Amorim
Summary: This study investigated the postmortem pathological features of six African pygmy hedgehogs and described a diverse set of pathologies. The findings highlight the important role of hedgehogs in the eco-epidemiological context of zoonotic diseases and emphasize the need for knowledge sharing between clinicians and pathologists.
Article
Biochemistry & Molecular Biology
Kyungjoo Cho, Hyuk Moon, Sang Hyun Seo, Simon Weonsang Ro, Beom Kyung Kim
Summary: The study showed that the sonic hedgehog signaling pathway is up-regulated in cholangiocarcinoma (CCC), and that the sonic hedgehog inhibitor vismodegib has a significant inhibitory effect on CCC cells. In vivo experiments using a murine model of CCC confirmed the anti-cancer efficacy of vismodegib, suggesting that pharmacological inhibition of sonic hedgehog signaling could be an effective molecular target therapy for CCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Liu-Ya Tang, Marie Spezia, Ting Chen, Jee-Hye Shin, Feng Wang, Frank Stappenbeck, Andres M. Lebensohn, Farhad Parhami, Ying E. Zhang
Summary: The study revealed that oxysterols Oxy186 and Oxy210 can inhibit proliferation of NSCLC cells, with Oxy186 exhibiting potent inhibition of tumor growth. The mechanism of action involves inhibiting the WNT/beta-catenin signaling pathway.
CELL AND BIOSCIENCE
(2022)
Article
Biodiversity Conservation
Alexander A. Kirillov, Nadezhda Yu Kirillova, Alexander B. Ruchin
Summary: The helminth fauna of Northern white-breasted hedgehogs in the Republic of Mordovia, Russia, includes various trematodes, cestodes, nematodes, and acanthocephalans, with some species being recorded for the first time in Russia. Hedgehogs serve as the final hosts for parasitic species with organic host relationships. The parasite communities of Erinaceus spp. in the Palearctic region are primarily influenced by host-specific parasites.
Article
Biochemistry & Molecular Biology
Maya Emmons-Bell, Iswar K. Hariharan
Summary: The membrane potential of cells is patterned in the Drosophila wing imaginal disc, with anterior cells near the boundary being more depolarized due to Hh signalling. This depolarization promotes membrane localization of Smoothened and enhances Hh signalling, demonstrating a mutual reinforcement between membrane depolarization and Hh-dependent signalling.
Article
Medicine, Research & Experimental
Licen Li, Jiaolin Bao, Haitao Wang, Josh Haipeng Lei, Cheng Peng, Jianming Zeng, Wenhui Hao, Xu Zhang, Xiaoling Xu, Chundong Yu, Chu-Xia Deng, Qiang Chen
Summary: The study reveals that AIB1 plays a crucial role in the progression of PDAC through Hh and ECM signaling pathways, suggesting potential therapeutic targets for PDAC treatment.
Article
Pharmacology & Pharmacy
Ming Ji, Zhihui Zhang, Songwen Lin, Chunyang Wang, Jing Jin, Nina Xue, Heng Xu, Xiaoguang Chen
Summary: A study found that a new inhibitor XH30 demonstrates anti-tumor activity against TMZ-resistant GBM by inhibiting cell proliferation and inducing cell cycle arrest. XH30 also showed effectiveness in suppressing TMZ-resistant tumor growth in an animal model and enhancing TMZ cytotoxicity. Mechanistically, XH30 may exert its synergistic effect by repressing the key transcription factor GLI1 via the noncanonical hedgehog signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nabin Kandel, Chunyu Wang
Summary: Hedgehog signaling is important in embryonic development and its abnormal activation is linked to cancer. The signaling is initiated by the Hh ligand generated through Hh autoprocessing. Autoprocessing is crucial for Hh signaling.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Dermatology
M. Slowinska, M. Dudzisz-Sledz, P. Sobczuk, I Lasinska, A. Pietruszka, B. Cybulska-Stopa, A. Kowalczyk, T. Switaj, I Czarnecka, H. Kosela-Paterczyk, P. Rogala, E. Paluchowska, K. Skladowski, J. Mackiewicz, P. Rutkowski, W. Owczarek
Summary: This retrospective study analyzed the efficacy and safety of vismodegib treatment in 108 patients with locally advanced or metastatic disease. The results showed that vismodegib had a good response rate and improved overall survival in these patients. Female gender was identified as an independent prognostic factor for progression-free survival.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
