Article
Chemistry, Multidisciplinary
Kenji Hirai, Hiroto Ishikawa, Yasufumi Takahashi, James A. Hutchison, Hiroshi Uji-i
Summary: Site-selective chemistry provides new approaches for synthesizing important molecules, and vibrational strong coupling (VSC) can modify the chemical reactivity at specific sites. In this study, actuatable FP cavities were developed to automatically adjust cavity mode energy and maintain maximized VSC during a reaction, resulting in improved site-selective reactivity.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Organic
Rui Wang, Yang Yu
Summary: This review summarizes various site-selective reactions mediated by molecular containers, with a focus on the differences in product distribution inside the containers compared to free solution reactions. The product selectivity is determined by the space shape and environment inside the container.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ayan Dasgupta, Katarina Stefkova, Rasool Babaahmadi, Brian F. Yates, Niklaas J. Buurma, Alireza Ariafard, Emma Richards, Rebecca L. Melen
Summary: The donor-acceptor ability of frustrated Lewis pairs has been widely used in organic synthesis. Single electron transfer can generate a frustrated radical pair, leading to different reaction pathways and selectivity depending on the substrate and energy required. Investigation using EPR studies, kinetic studies, and DFT calculations has helped elucidate the mechanism of these coupling reactions and explain solvent-dependent site selectivity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Multidisciplinary
Bijin Li, Mazen Elsaid, Haibo Ge
Summary: C(sp(3))-H functionalization is an important method to increase molecular complexity. Despite the initial challenges of inertness and high bond-dissociation energies, these hurdles can be overcome through selective strategies, leading to efficient construction of C-C and C-X bonds. This review discusses transition-metal-catalyzed site-selective gamma- and delta-C(sp(3))-H functionalization reactions and explores their applications in late-stage functionalization of medicinal compounds and construction of complex molecules of medicinal importance.
Article
Chemistry, Physical
Jaemook Lim, Byeonghwa Goh, Weihao Qu, Youngchan Kim, Joonmyung Choi, Sukjoon Hong
Summary: By inducing laser-induced photothermal reactions at a specific site on the PI/PDMS interface, an unexpected reinforcement of adhesion strength between the two materials can be achieved. This method has the potential to enable continuous bonding at the microscopic level and can be easily scaled up for practical applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Physical
Alejandro Lapresta-Fernandez, Evangelia Nefeli Athanasopoulou, Paulo Jacob Silva, Zekiye Pelin Guven, Francesco Stellacci
Summary: Surface modification of ligand-protected nanoparticles can be achieved through ligand exchange reactions. This study focuses on the mechanism of ligand exchange reactions and their effects on surface-enhanced Raman scattering (SERS). By studying the local order indicator of ligands, two different pathways of ligand exchange reactions were identified. These findings provide important insights into the surface modification of nanoparticles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Yaxu Zhong, Zeke Liu, Erik Sarnello, Tao Li, Yang Liu, Jun Chen, Xingchen Ye
Summary: The study reports the synthesis of inverse spinel-type cadmium stannate nanocrystals, in which cation-exchange reactions were developed to tailor their composition and LSPR properties. X-ray absorption spectroscopy studies revealed that the inequivalent tetrahedrally and octahedrally coordinated Cd2+ can be selectively exchanged for Cu+ and In3+ ions, enabling broadband tunable LSPR.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Sourav Sekhar Bera, Srishti Ballabh Bahukhandi, Claire Empel, Rene M. Koenigs
Summary: A site-selective direct arylation reaction of carbazole and other N-heterocycles with diazo-naphthalen-2(1H)-ones has been developed, showing the potential for selective C3-arylation with Au(i)-NHC catalysts and selective N-H arylation with palladium acetate. The applicability of these arylation reactions was demonstrated through one-pot, two-fold diarylation reactions of carbazole.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zahra Vari, Reza Ranjbar-Karimi, Kazem Mohammadiannejad
Summary: The nucleophilic substitution reactions of pentafluoropyridine with hydroxybenzaldehydes were examined, and the selectivity of reactions was found to be influenced by reaction conditions, reactant ratio, and nucleophilicity of the derived potassium formylphenolates. Under mild basic conditions, the nucleophilic attack occurred exclusively at the C-4 position of pentafluoropyridine, resulting in the formation of 4-((perfluoropyridin-yl)oxy)benzaldehydes in high yields. However, under harsh conditions, 3-hydroxybenzaldehyde acted as an effective nucleophile for replacing fluorine atoms at C-2 and/or C-6 positions of pentafluoropyridine. The controlled reactions of pentafluoropyridine with different amounts of 3-hydroxybenzaldehyde led to the synthesis of unsymmetrical products with varying yields.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Ana Novak, Florian Kersaudy, Sylvie Berger, Severine Morisset-Lopez, Francois Lefoulon, Carlo Pifferi, Vincent Aucagne
Summary: Site-selective, dual-conjugation approaches are important for the development of targeted biomolecules with improved properties. Combinations of drugs and probes can enhance molecular imaging and therapeutic outcomes. We have developed an efficient dual-bioconjugation strategy that can generate high-yield, high-purity dual conjugates under mild conditions. These dual conjugates exhibit potent cytotoxicity against HER2-expressing cells and show specificity for the target.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Weiyuan Huang, Jimin Qiu, Yuchen Ji, Wenguang Zhao, Zihang Dong, Kai Yang, Ming Yang, Qindong Chen, Mingjian Zhang, Cong Lin, Kang Xu, Luyi Yang, Feng Pan
Summary: By using LiCoO2 as a redox mediator, the decomposition of Na2CO3 can be catalyzed, enabling the effective harvest of electrochemical energy from insulating compounds and unlocking their potential capacity for energy storage.
Article
Chemistry, Physical
Dejiang Zhang, Ting Tang, Zhao Zhang, Liyuan Le, Zhi Xu, Hao Lu, Zhou Tong, Dishu Zeng, Wai-Yeung Wong, Shuang-Feng Yin, Arash Ghaderi, Nobuaki Kambe, Renhua Qiu
Summary: This study presents a general and efficient method for the synthesis of Sb-aryl and Sb-alkyl stibines through nickel-catalyzed cross-coupling reactions with organic halides. The method enables the high selectivity synthesis of complex biaryls and successfully synthesized various molecules, including drugs, with good yields.
Review
Biochemistry & Molecular Biology
Lucia De Rosa, Rossella Di Stasi, Alessandra Romanelli, Luca Domenico D'Andrea
Summary: This article provides an updated overview of methodologies developed to selectively modify proteins by targeting the N-terminal alpha-amine group. Chemical and enzymatic strategies for selective labeling of the protein N-terminal alpha-amine group are described.
Review
Chemistry, Multidisciplinary
Dibyendu Mondal, Harrison M. Snodgrass, Christian A. Gomez, Jared C. Lewis
Summary: The ability to selectively modify functional groups in a molecule can simplify syntheses and increase yields. Enzymes can catalyze site-selective transformations, but using this capability for non-native substrates and reactions requires understanding of enzymatic catalysis and protein engineering. This review discusses examples of site-selective enzyme catalysis involving functional group manipulation and C-H bond functionalization, focusing on cases with non-native substrates and engineered enzymes. The review also explores the use of these enzymes in chemoenzymatic transformations and target-oriented synthesis, and provides an overview of tools and techniques to expand the scope of non-native site-selective enzyme catalysis.
Article
Chemistry, Physical
Seyedeh Maryam Salehi, Markus Meuwly
Summary: The study characterizes the spectroscopic response and structural dynamics of all azido-modified alanine residues (AlaN(3)) in lysozyme, finding that AlaN(3) serves as a positionally sensitive probe for local dynamics. The static component magnitude of azide-attached alanine correlates qualitatively with the degree of hydration of the spectroscopic probe.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Jean-Francois Vincent-Rocan, Christian Clavette, Kyle Leckett, Andre M. Beauchemin
CHEMISTRY-A EUROPEAN JOURNAL
(2015)
Article
Chemistry, Organic
Kaitlyn Lavergne, Amanda Bongers, Lyanne Betit, Andre M. Beauchemin
Article
Chemistry, Multidisciplinary
Christian Clavette, Jean-Francois Vincent Rocan, Andre M. Beauchemin
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2013)
Article
Chemistry, Multidisciplinary
Xiao-Qiang Hu, Jia-Rong Chen, Qiang Wei, Feng-Lei Liu, Qiao-Hui Deng, Andre M. Beauchemin, Wen-Jing Xiao
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2014)
Article
Chemistry, Multidisciplinary
Melissa J. MacDonald, Colin R. Hesp, Derek J. Schipper, Marc Pesant, Andre M. Beauchemin
CHEMISTRY-A EUROPEAN JOURNAL
(2013)
Article
Chemistry, Multidisciplinary
Sheng-Ying Hsieh, Benedikt Wanner, Philip Wheeler, Andre M. Beauchemin, Tomislav Rovis, Jeffrey W. Bode
CHEMISTRY-A EUROPEAN JOURNAL
(2014)
Article
Chemistry, Organic
Nicolas Das Neves, Michael Raymond, Andre M. Beauchemin
Article
Chemistry, Inorganic & Nuclear
Fatemah Habib, Gabriel Brunet, Francis Loiseau, Thushan Pathmalingam, Tara J. Burchell, Andre M. Beauchemin, Wolfgang Wernsdorfer, Rodolphe Clerac, Muralee Murugesu
INORGANIC CHEMISTRY
(2013)
Article
Chemistry, Organic
Isabelle Dion, Jean-Francois Vincent-Rocan, Lei Zhang, Pamela H. Cebrowski, Marie-Eve Lebrun, Jennifer Y. Pfeiffer, Anne-Catherine Bedard, Andre M. Beauchemin
JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Organic
Ashley D. Hunt, Isabelle Dion, Nicolas Das Neves, Sandrine Taing, Andre M. Beauchemin
JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Organic
Andre M. Beauchemin
ORGANIC & BIOMOLECULAR CHEMISTRY
(2013)
Article
Chemistry, Organic
Mariya Chigrinova, Craig S. McKay, Louis-Philippe B. Beaulieu, Konstantin A. Udachin, Andre M. Beauchemin, John Paul Pezacki
ORGANIC & BIOMOLECULAR CHEMISTRY
(2013)
Article
Chemistry, Organic
Keira Garland, Wei Gan, Charlotte Depatie-Sicard, Andre M. Beauchemin
Article
Chemistry, Organic
Wei Gan, Patrick J. Moon, Christian Clavette, Nicolas Das Neves, Thomas Markiewicz, Amy B. Toderian, Andre M. Beauchemin
