Review
Anatomy & Morphology
Chantal Thibert, Anthony Lucas, Marc Billaud, Sakina Torch, Marie Mevel-Aliset, Jordan Allard
Summary: Neural crest cells are embryonic cells that migrate long distances to reach target organs and give rise to various derivatives. Recent studies have highlighted the crucial role of the metabolic kinase LKB1 in the establishment and maintenance of neural crest derivatives. The underlying molecular mechanisms involve the AMPK-mTOR signaling pathway, offering potential therapeutic applications for neural crest disorders.
DEVELOPMENTAL DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
C. H. Frere, G. D. O'Reilly, K. Strickland, A. Schultz, K. Hohwieler, J. Hanger, D. de Villiers, R. Cristescu, D. Powell, W. Sherwin
Summary: The genetic consequences of population subdivision in human-impacted landscapes are significant for long-term evolution. This study analyzes the effects of population subdivision on genetic diversity using koala population data and proposes a method to evaluate mitigation measures.
Review
Biochemistry & Molecular Biology
Maria S. Yurkova, Alexey N. Fedorov
Summary: Chaperones play a vital role in cell life and can be used in biotechnology and scientific research.
Article
Multidisciplinary Sciences
Beverly Setzer, Nina E. Fultz, Daniel E. P. Gomez, Stephanie D. Williams, Giorgio Bonmassar, Jonathan R. Polimeni, Laura D. Lewis
Summary: We discovered a sequence of activity across the thalamus that precedes transitions from unresponsiveness to active behavior. These thalamic dynamics are linked to whether participants subsequently fall back into unresponsiveness.
NATURE COMMUNICATIONS
(2022)
Article
Psychology, Multidisciplinary
Juliette L. Ratchford, Sarah A. Schnitker, Paul Reppas
Summary: The study aims to establish thrift as a psychological construct through the development and validation of a Thrift Questionnaire measuring five thrift factors, revealing three different profiles. Participants classified under sanctified thrift demonstrate higher levels of generosity and gratitude.
JOURNAL OF HAPPINESS STUDIES
(2021)
Review
Immunology
Jai S. Bolton, Hannah Klim, Judith Wellens, Matthew Edmans, Uri Obolski, Craig P. Thompson
Summary: The antigenic drift theory posits that influenza evolves through gradual mutations, while the competing theory of antigenic thrift suggests that immune selection targets epitopes of limited variability, constraining the virus' variability. Both theories aim to explain the dominance of a single or limited number of influenza strains each season, despite the potential for multiple strains to co-circulate based on mutation in multiple epitopes.
Article
Neurosciences
Valerie J. Sydnor, Bart Larsen, Jakob Seidlitz, Azeez Adebimpe, Aaron F. Alexander-Bloch, Dani S. Bassett, Maxwell A. Bertolero, Matthew Cieslak, Sydney Covitz, Yong Fan, Raquel E. Gur, Ruben C. Gur, Allyson P. Mackey, Tyler M. Moore, David R. Roalf, Russell T. Shinohara, Theodore D. Satterthwaite
Summary: Animal studies have shown that intrinsic cortical activity evolves during neurodevelopment. Leveraging fMRI data from 1,033 youths, this study demonstrates a hierarchical cortical axis of neurodevelopment in humans. The maturation of intracortical myelin is coupled to the decline in amplitude of intrinsic fMRI activity. The findings also suggest that environmental influences on the maturing brain diverge along the sensorimotor-association cortical axis during midadolescence.
NATURE NEUROSCIENCE
(2023)
Article
Microbiology
Mohamad Al Kadi, Eiji Ishii, Dang Tat Truong, Daisuke Motooka, Shigeaki Matsuda, Tetsuya Iida, Toshio Kodama, Daisuke Okuzaki
Summary: Conventional bacterial genome annotation often overlooks untranslated regions and operons, but direct RNA sequencing technology enables a more comprehensive annotation of bacterial transcriptomes. The study using direct RNA sequencing on Vibrio parahaemolyticus revealed a deeper view of transcription start site classification and provided quantitative and high-resolution annotation of its transcriptome features.
Article
Engineering, Environmental
Carsten Simon, Kai Duehrkop, Daniel Petras, Vanessa-Nina Roth, Sebastian Boecker, Pieter C. Dorrestein, Gerd Gleixner
Summary: Delta m matching can reveal structural information in complex mixtures and assess the quality of molecular formulas.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Neurosciences
Jay A. Hennig, Emily R. Oby, Darby M. Losey, Aaron P. Batista, Byron M. Yu, Steven M. Chase
Summary: Learning in the brain involves optimizing objectives or cost functions, but there are unique features of neural activity that cannot be explained solely through optimization, such as neural variability inflexibility, multiple learning processes even during simple tasks, and large task-nonspecific activity changes. Understanding these features will be crucial for describing biological learning within an optimization framework.
Article
Business
Daniel Hellstrom, John Olsson
Summary: This research investigates the opportunities and driving factors of circular business model innovation in the fashion industry, and puts forward 13 business model propositions to further develop this theory. The findings reveal that consumer centricity and logistics services as catalysts contribute to circular business model innovation, supporting the transformation of retail towards a circular economy.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2024)
Article
Biochemistry & Molecular Biology
Denitsa Yaneva, Justin L. Sparks, Maximilian Donsbach, Shubo Zhao, Pedro Weickert, Rachel Bezalel-Buch, Julian Stingele, Johannes C. Walter
Summary: Endogenous and exogenous agents generate DNA-protein crosslinks (DPCs), whose replication-dependent degradation by the SPRTN protease suppresses aging and liver cancer. In this study, it is found that the helicase FANCJ plays a role in DPC repair by binding to ssDNA downstream of the DPC and using its ATPase activity to unfold the protein adduct, enabling cleavage of the adduct and facilitating translesion DNA synthesis past DPCs that cannot be degraded. These findings highlight the importance of helicase-mediated protein unfolding in DPC repair.
Article
Green & Sustainable Science & Technology
Hsien-Ming Chou, Cheng-Wen Lee, Tsai-Lun Cho
Summary: This research discusses the challenges faced by charity thrift stores when employing individuals with disabilities and focuses on the satisfaction of such individuals participating in service-learning courses. The results of the study indicate that education, training, and process improvements for internal staff, as well as efforts to improve customers' perception, can enhance service-learning satisfaction.
Article
Endocrinology & Metabolism
Maaike E. Straat, Borja Martinez-Tellez, Aashley Sardjoe Mishre, Magdalena M. A. Verkleij, Mirjam Kemmeren, Iris C. M. Pelsma, Juan M. A. Alcantara, Andrea Mendez-Gutierrez, Sander Kooijman, Mariette R. Boon, Patrick C. N. Rensen
Summary: Cold-induced thermogenesis is higher in the morning for males, while lipid metabolism is more modulated in the morning for females.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Philip To, Yingzi Xia, Sea On Lee, Taylor Devlin, Karen G. Fleming, Stephen D. Fried
Summary: The process of protein folding is complex and important, involving cellular factors and processes. Researchers have developed a new method to monitor the structural changes of Escherichia coli proteins in the cell cytosol and with chaperones. The results show that GroEL can assist in refolding the majority of proteins, while DnaK and GroEL have a similar set of proteins that they refold. Additionally, some proteins are not able to be refolded with any chaperones.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Erik J. Liu, Andrew Sinclair, Andrew J. Keefe, Brent L. Nannenga, Brandon L. Coyle, Francois Baneyx, Shaoyi Jiang
Article
Multidisciplinary Sciences
Jose A. Rodriguez, Magdalena I. Ivanova, Michael R. Sawaya, Duilio Cascio, Francis E. Reyes, Dan Shi, Smriti Sangwan, Elizabeth L. Guenther, Lisa M. Johnson, Meng Zhang, Lin Jiang, Mark A. Arbing, Brent L. Nannenga, Johan Hattne, Julian Whitelegge, Aaron S. Brewster, Marc Messerschmidt, Bastien Boutet, Nicholas K. Sauter, Tamir Gonen, David S. Eisenberg
Article
Biochemistry & Molecular Biology
Brent L. Nannenga, Tamir Gonen
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2016)
Article
Biochemical Research Methods
Dan Shi, Brent L. Nannenga, M. Jason de la Cruz, Jinyang Liu, Steven Sawtelle, Guillermo Calero, Francis E. Reyes, Johan Hattne, Tamir Gonen
Article
Biology
Pascal Krotee, Jose A. Rodriguez, Michael R. Sawaya, Duilio Cascio, Francis E. Reyes, Dan Shi, Johan Hattne, Brent L. Nannenga, Marie E. Oskarsson, Stephan Philipp, Sarah Griner, Lin Jiang, Charles G. Glabe, Gunilla T. Westermark, Tamir Gonen, David S. Eisenberg
Article
Biotechnology & Applied Microbiology
Amar Thaker, Karthik Pushpavanam, Tomasz Bista, Stephen Sapareto, Kaushal Rege, Brent L. Nannenga
BIOTECHNOLOGY AND BIOENGINEERING
(2019)
Article
Chemistry, Physical
Brent L. Nannenga
STRUCTURAL DYNAMICS-US
(2020)
Article
Biochemistry & Molecular Biology
Lan Zhu, Guanhong Bu, Liang Jing, Dan Shi, Ming-Yue Lee, Tamir Gonen, Wei Liu, Brent L. Nannenga
Article
Biotechnology & Applied Microbiology
Amar Thaker, Luqmanal Sirajudeen, Chad R. Simmons, Brent L. Nannenga
Summary: The study demonstrates that maltose-binding protein (MBP) can facilitate stable gold nanoparticle synthesis, with the structure of MBP in the presence of gold ions determined by X-ray crystallography. A peptide (AT1) selected and synthesized based on this structure also aids in the synthesis of stable gold nanoparticles, representing a new potential method for peptide selection in nanoparticle synthesis.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Chemistry, Multidisciplinary
Lisa J. Clark, Guanhong Bu, Brent L. Nannenga, Tamir Gonen
Summary: Microcrystal electron diffraction (MicroED) is a cutting-edge technique used to determine molecular structures, particularly in drug discovery and development. It is valuable for studying protein-ligand interactions and natural product structures, with applications in rational drug design and optimization.
NATURE REVIEWS CHEMISTRY
(2021)
Article
Chemistry, Physical
Sankarsan Biswas, Sayan Banerjee, Milan A. Shlain, Andrey A. Bardin, Rein Ulijn, Brent L. Nannenga, Andrew M. Rappe, Adam B. Braunschweig
Summary: Tuning solubility and mechanical activation can alter the stereoselectivity of the [2 + 2] photochemical cycloaddition reaction. The solid-state reaction and the reaction in organic solvents yield the anti and syn products, respectively. DFT calculations show that the solid-state reaction proceeds via a covalently bonded excimer, driving anti selectivity. Under photomechanochemical conditions, the noncovalently bound syn conformer experiences greater destabilization, leading to the formation of the syn product. This work demonstrates the viability of photomechanochemistry for the preparation of complex organic scaffolds.
FARADAY DISCUSSIONS
(2023)
Article
Chemistry, Multidisciplinary
Xing Han, S. Ephraim Neumann, Brent L. Nannenga, Kaiyu Wang, Kelvin Kam-Yun Li, Saber Mirzaei, Xuan Yao, Chenhui Zhu, Mei-Yan Gao, Yue-Biao Zhang, Yong Cui, Omar M. Yaghi
Summary: This study demonstrates a new strategy to access 2D woven covalent organic frameworks (COFs) by controlling the angle of the linker, resulting in the successful synthesis of a 2D woven pattern based on a chain-link fence structure. The work significantly advances the concept of molecular weaving and its application in the design of complex chemical structures.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Nanoscience & Nanotechnology
Sagnik Sen, Amar Thaker, Luqmanal Sirajudeen, Dewight Williams, Brent L. Nannenga
Summary: This study demonstrates the potential of cryo-EM analysis to reveal structural details of protein-nanoparticle complexes, using GroEL-PtNP and ferritin bound to iron oxide nanoparticles as model samples.
ACS APPLIED BIO MATERIALS
(2022)
Article
Multidisciplinary Sciences
Michael W. Martynowycz, Anna Shiriaeva, Xuanrui Ge, Johan Hattne, Brent L. Nannenga, Vadim Cherezov, Tamir Gonen
Summary: This study demonstrates how the structure of a human A2A adenosine receptor can be determined using MicroED, and lays the groundwork for future structural studies of lipid-embedded membrane proteins using single microcrystals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Andrew M. Levine, Guanhong Bu, Sankarsan Biswas, Esther H. R. Tsai, Adam B. Braunschweig, Brent L. Nannenga
CHEMICAL COMMUNICATIONS
(2020)
