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Proteolytic needles in the cellular haystack

Journal

NATURE CHEMICAL BIOLOGY
Volume 4, Issue 11, Pages 651-652

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio1108-651

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The execution phase of cell death is driven by specific proteolytic signaling through cleavage of proteins by caspases. Within the mix of hundreds of newly identified caspase substrates lie the crucial proteolytic events whose sum defines the unique morphology known as apoptosis.

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