Journal
NATURE CELL BIOLOGY
Volume 15, Issue 10, Pages 1137-1139Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2857
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Cytoplasmic compartments containing misfolded proteins targeted for degradation, named Q-bodies, have been identified. Q-body formation is a dynamic process that actively manages the metastable state of the protein fold through small heat shock proteins and the Hsp70-Hsp90-Hsp110 proteostasis system to promote cellular fitness under both physiological and stress conditions.
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