Review
Pharmacology & Pharmacy
Ping Zhu, Yan Li, Ting Guo, Simei Liu, Changhua Hu, Chengzhi Zhao, Chaoyang Xue, Guojian Liao
Summary: The increasing occurrence of invasive fungal infections and rising drug resistance rates pose a significant threat to human health. Antifungal drug combinations have attracted substantial interest for their potential to improve efficacy, reduce doses, and overcome drug resistance. Understanding the molecular mechanisms of antifungal drug resistance and drug combination is crucial for developing new therapeutic approaches.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Alina Chrzastek, Ioanna A. Thanasi, James A. Irving, Vijay Chudasama, James R. Baker
Summary: Disulfide bridging is a powerful strategy for constructing selective protein bioconjugates. This study introduces a new class of reagents with a stable-labile design, allowing for robust attachment to one cysteine residue and reactive handle for subsequent bioconjugation at the other. By incorporating thioesters, the reagents can undergo native chemical ligation with N-terminal cysteines, expanding the scope of disulfide bridging strategies.
Article
Biochemistry & Molecular Biology
Jhon K. A. Pereira, Andre G. C. Costa, Edson S. B. Rodrigues, Isaac Y. L. Macedo, Marx O. A. Pereira, Ricardo Menegatti, Severino C. B. de Oliveira, Freddy Guimaraes, Luciano M. Liao, Jose R. Sabino, Eric de S. Gil
Summary: This study investigates the potential of a novel analogue of trimetozine antioxidant using electrochemical and DFT calculation approaches. The electrochemical behavior and electronic structure of the compound, LQFM289, were examined, revealing its potential as a therapeutic agent with good redox properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Thomas A. K. Prescott, Rowena Hill, Eduard Mas-Claret, Ester Gaya, Edie Burns
Summary: Fungal-derived drugs have had significant impacts in treating chronic diseases and saving lives. However, the discovery process has become more challenging after the easy discoveries have been made. The entry of new players with genomic tools may change the landscape and facilitate future discoveries.
Article
Nutrition & Dietetics
Yu-Ting Ho, Ying-Chieh Tsai, Terry B. J. Kuo, Cheryl C. H. Yang
Summary: This study found that PS128 can improve depressive symptoms, fatigue levels, brainwave activity, and awakenings during deep sleep, with changes related to brain waves and sleep maintenance. Daily intake of PS128 may help improve depressive symptoms and sleep quality in insomniacs.
Article
Environmental Sciences
Francesca Conte, Serena Malloggi, Oreste De Rosa, Ilaria Di Iorio, Federica Romano, Fiorenza Giganti, Gianluca Ficca
Summary: This study compared good sleepers, poor sleepers, and insomniacs using polysomnography and found that insomniacs showed significant differences in sleep macrostructure, continuity, stability, and organization compared to good sleepers, while poor sleepers only showed disrupted continuity and stability. These findings support the hypothesis of a continuum between individuals with self-reported poor sleep and insomniacs and emphasize the importance of including these measures in standard sleep assessments.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Sahar M. Sabet, Natalie D. Dautovich, Joseph M. Dzierzewski
Summary: The study examined the role of sleep thoughts and behaviors as mediators of the association between social rhythms and mental health symptoms of depression and anxiety in a sample of 3,284 adults. The results showed that greater social rhythmicity is directly associated with fewer depressive and anxiety symptoms, and that healthier sleep behaviors and thoughts mediate this association. The findings highlight the critical role lifestyle regularity plays in depressive and anxious symptom pathology, with sleep behaviors and thoughts playing complementary roles in the link between regularity and mental health.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Farrah Syazana Khattulanuar, Mahendran Sekar, Shivkanya Fuloria, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Subban Ravi, Kumarappan Chidambaram, M. Yasmin Begum, Abul Kalam Azad, Srikanth Jeyabalan, Arulmozhi Dhiravidamani, Lakshmi Thangavelu, Pei Teng Lum, Vetriselvan Subramaniyan, Yuan Seng Wu, Kathiresan V. Sathasivam, Neeraj Kumar Fuloria
Summary: This review summarizes the extensive research on tilianin as a treatment for cardiovascular disorders. Tilianin has cardioprotective properties and can be used in the therapy of diseases such as coronary heart disease, angina pectoris, hypertension, and myocardial ischemia. The cardioprotective actions of tilianin are believed to be achieved through mechanisms such as free radical scavenging, inflammation control, and mitochondrial function regulation.
Article
Engineering, Industrial
Dan Basacik, Anisha Tailor
Summary: The relationship between sleep and health and wellbeing is receiving increasing attention; fatigue is identified as a factor in high-risk incidents in the railway industry; sleep patterns of railway workers show insufficient sleep during night shifts and greater sleep on days off, indicating a "feast-and-famine" pattern.
APPLIED ERGONOMICS
(2022)
Article
Chemistry, Medicinal
Lutete Peguy Khonde, Rudolf Mueller, Grant A. Boyle, Virsinha Reddy, Aloysius T. Nchinda, Charles J. Eyermann, Stephen Fienberg, Vinayak Singh, Alissa Myrick, Efrem Abay, Mathew Njoroge, Nina Lawrence, Qin Su, Timothy G. Myers, Helena I. M. Boshoff, Clifton E. Barry, Frederick A. Sirgel, Paul D. van Helden, Lisa M. Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gregory S. Basarab, Sandeep R. Ghorpade, Kelly Chibale
Summary: A study identified a moderately active compound against Mycobacterium tuberculosis through high-throughput screening, with potential bactericidal activity and retention of activity against drug-resistant strains. Initial investigations suggested inhibition of cell wall biosynthesis as a possible mode of action, but the specific mechanism remains unclear.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Juergen Drewe, Georg Boonen, Carsten Culmsee
Summary: Cimicifuga extracts alleviate menopausal symptoms and age-related metabolic changes by modulating the AMP-activated protein kinase.
Article
Chemistry, Physical
Min Zhu, Hai Ping Shao, Hong Lin Zhai, Yajie Meng, Ruirui Liu, Cuiling Ren
Summary: This study evaluated the application of ReNPs as a drug delivery platform using molecular dynamics simulation, and investigated the mechanism of drug release. The results showed that ReNPs platform has good biocompatibility and stability, making it suitable for the delivery of HSP90 inhibitors.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Oncology
Yanqing Li, Ziyu Luo, Xinxing Wang, Songtao Zhang, Hu Hei, Jianwu Qin
Summary: Medullary thyroid carcinoma is a common malignant endocrine tumor that seriously affects human health. Surgical resection offers a potentially curative option, but most patients cannot benefit due to difficulty accessing the tumors. Recent advances in research have improved our understanding of the molecular mechanisms and enabled the development of targeted drugs for MTC. This article reviews the molecular mechanisms and principles for designing targeted drugs, and proposes future directions for prospective studies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Peng Xue, Rui Sang, Nan Li, Siyuan Du, Xiuwen Kong, Mingliang Tai, Zhihao Jiang, Ying Chen
Summary: With the irresponsible use of antibiotics and the increasing misuse of oral antibiotics, the resistance of gastrointestinal pathogens has become a major issue in clinical practice. The gut microbiota plays a crucial role in maintaining human health, and alterations in microbiota also influence the activity of pathogenic bacteria. Interfering with antibiotic-resistant bacteria by modulating the gut microbiota has emerged as an important regulatory mechanism. Traditional Chinese medicine, with its unique advantages in sterilization and tackling drug resistance, may be able to improve the gut microbial environment. This review discusses the strategies of traditional Chinese medicine in treating drug-resistant bacterial infections by modifying the gut microenvironment and elucidates the interplay between microbiota and the drug resistance of pathogenic bacteria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Melanie A. Mcdowell, Michael Heimes, Giray Enkavi, Akos Farkas, Daniel Saar, Klemens Wild, Blanche Schwappach, Ilpo Vattulainen, Irmgard Sinning
Summary: This study reveals the structure and functional characteristics of the guided entry of tail-anchored proteins (GET) insertase, including its remodeling of the membrane environment to promote substrate insertion.
NATURE COMMUNICATIONS
(2023)