Article
Public, Environmental & Occupational Health
Ruy Freitas Reis, Rafael Sachetto Oliveira, Barbara de Melo Quintela, Joventino de Oliveira Campos, Johnny Moreira Gomes, Bernardo Martins Rocha, Marcelo Lobosco, Rodrigo Weber dos Santos
Summary: Mathematical models have been widely used in controlling the COVID-19 pandemic, but they often fail to forecast the pandemic peaks accurately due to the misestimation of transmission rate. Significant changes in transmission rate commonly precede a peak, challenging the task of forecasting the pandemic peak. Mathematical modeling can be helpful in controlling the pandemic by characterizing essential features and testing different scenarios and strategies.
FRONTIERS IN PUBLIC HEALTH
(2021)
Editorial Material
Cell & Tissue Engineering
Yu Fu, Yuanyue Shan, Mingfeng Zhang, Duanqing Pei
Summary: Oct4 undergoes phase separation to reconfigure TAD architecture for cell fate control, demonstrating how master regulators can shape 3D genome architecture during cell reprogramming.
Article
Oncology
M. Varughese
Summary: Despite evidence showing the benefits of certain interventions for non-metastatic muscle-invasive bladder cancer, most patients do not undergo curative-intent treatments, with the causes for this disparity not clearly understood.
Article
Developmental Biology
Robert N. Kelsh, Karen Camargo Sosa, Saeed Farjami, Vsevolod Makeev, Jonathan H. P. Dawes, Andrea Rocco
Summary: Neural crest cells play a crucial role in development due to their multipotency. Different hypotheses have been proposed regarding how fate specification and commitment occur, with a novel 'cyclical fate restriction' hypothesis being suggested as a way to reconcile experimental evidence.
Editorial Material
Cell Biology
Jessica Brooke Spinelli, Elma Zaganjor
Summary: Mitochondria are asymmetrically distributed to daughter cells based on their age, with metabolic features associated with mitochondrial age regulating cell fate decisions.
NATURE CELL BIOLOGY
(2022)
News Item
Geosciences, Multidisciplinary
William Ford, James Fox
Summary: The fate of sedimentary carbon in rivers is determined by a combination of mineral protection and transit time. Biogeochemical transformations along the journey control whether carbon is buried or returned to the atmosphere as CO2.
News Item
Geosciences, Multidisciplinary
Thomas L. L. O'Halloran, Georgia S. S. Seyfried
Summary: According to a four-year field study on a coastal wetland, it was found that some coastal marshes may struggle to build up soil elevation under future climate conditions, despite the potential reduction in methane emissions.
Article
Cell Biology
Xin Wang, Fengling Lai, Dantong Shang, Yibin Cheng, Tian Lan, Hanhua Cheng, Rongjia Zhou
Summary: The study provides a comprehensive single-cell developmental atlas of ovotestis and reveals the interactions between germline and niche cells that determine the fate of male and female germlines. The findings offer novel insights into ovotestis development and shed light on the cellular fate map shaping cell differentiation in ovotestis.
CELL DEATH & DISEASE
(2021)
Review
Cell & Tissue Engineering
Nan Hu, Linqing Zou, Cheng Wang, Guoqi Song
Summary: RUNX1T1 plays important roles in acute myeloid leukemia, neuronal development, intestinal development, adipogenesis, angiogenesis, and carcinogenesis, affecting cell fate through transcriptional regulation and signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Editorial Material
Hematology
Shangqin Guo
Summary: The study demonstrates that the dynamics of NF-kappa B signaling vary among different purified hematopoietic progenitor cells. In response to inflammatory signals, GMP(M) cells tend to undergo multiple rounds of nuclear-cytoplasmic translocation, while their bipotent predecessors, GMP(GM) cells, mostly experience a single activation of NF-kappa B. Forcing GMP(GM) cells into the oscillating state directs their fate trajectory towards becoming macrophages.
Article
Multidisciplinary Sciences
Faqiang Zhan, Chubashini Shunthirasingham, Yuening Li, Jenny Oh, Ying Duan Lei, Amina Ben Chaaben, Abigaelle Dalpe Castilloux, Zhe Lu, Kelsey Lee, Frank A. P. C. Gobas, Nick Alexandrou, Hayley Hung, Frank Wania
Summary: Halomethoxybenzenes are organic compounds that are present in the atmosphere at higher concentrations than persistent organic pollutants. They have properties of persistence, long-range transport, bioaccumulation, and toxicity. These compounds are primarily synthesized by wood-rotting fungi, marine algae, and invertebrates, and enter the atmosphere through evaporation from water. Our research provides evidence of their continental-scale transport and sheds light on their widespread atmospheric dispersal.
Article
Literature
Amelia Dale
Summary: Quixotism is a pivotal term in the study of literature, but there are discrepancies in its definition. It is seen as a dichotomy between romance and the novel, the exceptional and the typical, the original and the copy, and reason and imagination. This article reflects on the current state of quixotic studies and explores Don Quixote's place in the history of literary criticism and theory.
LITERATURE COMPASS
(2022)
Editorial Material
Multidisciplinary Sciences
Le Li, Florencia McAllister
Summary: The discovery shows that molecules from gut microorganisms can influence the success of chemotherapy for pancreatic cancer, indicating the potential use of nutritional interventions to improve outcomes.
Editorial Material
Cell Biology
Zhe Wu, Chuchu Zhou, Huilin Que, Yufen Wang, Yueguang Rong
Summary: During macroautophagy/autophagy, autophagosomes fuse with lysosomes to form autolysosomes. After fusion, the autophagosome inner membrane and enclosed substrates are degraded and transported out of lysosomes for recycling. The lysosomal membrane components are recycled by autophagic lysosome reformation (ALR) to generate new lysosomes.However, the fate of autophagosome outer membrane components on autolysosomes remains unknown. Our recent work discovered that autophagosome outer membrane components are not degraded but are recycled through an unidentified process which we named autophagosomal components recycling (ACR). Further investigation revealed the recycler complex (SNX4-SNX5-SNX17) responsible for ACR. The discovery of ACR not only fills a missing part in autophagy, but also reveals a new recycling pathway on autolysosomes.
Editorial Material
Cell Biology
Rui Yi, Yali Dou
Summary: A study uncovers that Pioneer transcription factors can bind closed chromatin regions, modify local accessibility, and activate target genes. The SOX9 transcription factor drives cell fate switching by activating hair follicle cell enhancers, while simultaneously repressing epidermal enhancers through sequestration of epigenetic factors.
NATURE CELL BIOLOGY
(2023)
