Dynamic basis for dG•dT misincorporation via tautomerization and ionization

DNA Polymerase λ Active Site Favors a Mutagenic Mispair between the Enol Form of Deoxyguanosine Triphosphate Substrate and the Keto Form of Thymidine Template: A Free Energy Perturbation Study

(2017) Sergey N. Maximoff et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson–Crick-like Base Pairs

(2017) Eric S. Szymanski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ensemble cryo-EM elucidates the mechanism of translation fidelity

(2017) Anna B. Loveland et al.   NATURE

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

(2017) Cristian Tomasetti et al.   SCIENCE

Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity

(2016) Keriann Oertell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Structural Insights into Translational Miscoding

(2016) Alexey Rozov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Atomistic picture of conformational exchange in a T4 lysozyme cavity mutant: an experiment-guided molecular dynamics study

(2016) Pramodh Vallurupalli et al.   Chemical Science

Visualizing transient Watson–Crick-like mispairs in DNA and RNA duplexes

(2015) Isaac J. Kimsey et al.   NATURE

Capturing snapshots of APE1 processing DNA damage

(2015) Bret D Freudenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Accuracy of initial codon selection by aminoacyl-tRNAs on the mRNA-programmed bacterial ribosome

(2015) Jingji Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the translational infidelity mechanism

(2015) Alexey Rozov et al.   Nature Communications

Capturing snapshots of APE1 processing DNA damage

(2015) Bret D Freudenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

(2015) Ashok Sekhar et al.   eLife

The nature of the transition mismatches with Watson–Crick architecture: the G*·T or G·T* DNA base mispair or both? A QM/QTAIM perspective for the biological problem

(2014) Ol’ha O. Brovarets’ et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β

(2014) Myong-Chul Koag et al.   NUCLEIC ACIDS RESEARCH

Significant contribution of the 3′→5′ exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ϵ

(2014) Walter J. Zahurancik et al.   NUCLEIC ACIDS RESEARCH

Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant

(2014) Shuangluo Xia et al.   PROTEIN SCIENCE

Structural Basis of the Translational Elongation Cycle

(2013) Rebecca M. Voorhees et al.   Annual Review of Biochemistry

Kinetic Mechanism of DNA Polymerization Catalyzed by Human DNA Polymerase ε

(2013) Walter J. Zahurancik et al.   BIOCHEMISTRY

Observing a DNA Polymerase Choose Right from Wrong

(2013) Bret D. Freudenthal et al.   CELL

Exceeding the limit of dynamics studies on biomolecules using high spin-lock field strengths with a cryogenically cooled probehead

(2012) David Ban et al.   JOURNAL OF MAGNETIC RESONANCE

A new understanding of the decoding principle on the ribosome

(2012) Natalia Demeshkina et al.   NATURE

Kinetic Mechanism of Active Site Assembly and Chemical Catalysis of DNA Polymerase β

(2011) Paul B. Balbo et al.   BIOCHEMISTRY

Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication infidelity via a mismatch with Watson–Crick geometry

(2011) Katarzyna Bebenek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending the Range of Microsecond-to-Millisecond Chemical Exchange Detected in Labeled and Unlabeled Nucleic Acids by Selective Carbon R1ρNMR Spectroscopy

(2009) Alexandar L. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY