Overcoming the limitations of directed C–H functionalizations of heterocycles

Non-directed allylic C–H acetoxylation in the presence of Lewis basic heterocycles

(2014) Hasnain A. Malik et al.   Chemical Science

Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

(2013) Heike Schönherr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unravelling the labyrinth of palladium-catalysed reactions involving isocyanides

(2013) Stuart Lang   CHEMICAL SOCIETY REVIEWS

Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

(2013) Marian C. Bryan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fused Heteroaromatic Dihydrosiloles: Synthesis and Double-Fold Modification

(2013) Alexey Kuznetsov et al.   ORGANIC LETTERS

Overcoming the “Oxidant Problem”: Strategies to Use O2 as the Oxidant in Organometallic C–H Oxidation Reactions Catalyzed by Pd (and Cu)

(2012) Alison N. Campbell et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rhodium(III) and Hexabromobenzene-A Catalyst System for the Cross-Dehydrogenative Coupling of Simple Arenes and Heterocycles with Arenes Bearing Directing Groups

(2012) Joanna Wencel-Delord et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphine-Free Palladium-Catalyzed Direct Arylation of Imidazo[1,2-a]pyridines with Aryl Bromides at Low Catalyst Loading

(2012) Hai Yan Fu et al.   JOURNAL OF ORGANIC CHEMISTRY

Activation of remote meta-C–H bonds assisted by an end-on template

(2012) Dasheng Leow et al.   NATURE

Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

(2011) Keary M. Engle et al.   ACCOUNTS OF CHEMICAL RESEARCH

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

(2011) Nicholas A. Meanwell   CHEMICAL RESEARCH IN TOXICOLOGY

Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds

(2011) Charles S. Yeung et al.   CHEMICAL REVIEWS

Rh(NHC)-Catalyzed Direct and Selective Arylation of Quinolines at the 8-Position

(2011) Jaesung Kwak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Direct C–H Bond Arylations of Heteroarenes

(2011) Lutz Ackermann et al.   ORGANIC LETTERS

Pd0/PR3-Catalyzed Arylation of Nicotinic and Isonicotinic Acid Derivatives

(2010) Masayuki Wasa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Iridium-Catalyzed CH Activation versus DirectedorthoMetalation: Complementary Borylation of Aromatics and Heteroaromatics

(2010) Timothy E. Hurst et al.   CHEMISTRY-A EUROPEAN JOURNAL

The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Selective C-4 Alkylation of Pyridine by Nickel/Lewis Acid Catalysis

(2010) Yoshiaki Nakao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bimetallic Nickel Aluminun MediatedPara-Selective Alkenylation of Pyridine: Direct Observation of η2,η1-Pyridine Ni(0)−Al(III) Intermediates Prior to C−H Bond Activation

(2010) Chung-Chih Tsai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium- and Copper-Catalyzed Arylation of Carbon−Hydrogen Bonds

(2009) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

Looking Forward in Pharmaceutical Process Chemistry

(2009) I. W. Davies et al.   SCIENCE

Pd(II)-Catalyzed Cross-Coupling of sp3C−H Bonds with sp2and sp3Boronic Acids Using Air as the Oxidant

(2008) Dong-Hui Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY