Review
Ecology
Stuart A. Harrison, Hanadi Rammu, Feixue Liu, Aaron Halpern, Raquel Nunes Palmeira, Nick Lane
Summary: This article discusses the continuum of life from simple prebiotic chemistry to cells with genes and molecular machines. The authors explore how selection could promote increased complexity before the emergence of genes. They propose that structured, far-from-equilibrium environments, such as hydrothermal systems, can drive the reaction between CO2 and H-2 to form self-organizing protocells. CO2 fixation within protocells generates a reaction network that prefigures the universal core of metabolism and promotes growth.
ANNUAL REVIEW OF ECOLOGY EVOLUTION AND SYSTEMATICS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Lorenzo Sebastianelli, Sheref S. Mansy
Summary: Encapsulation of RNA within model protocells plays an active role in the origins of life by promoting folding, substrate binding, catalysis, and protection against denaturation.
Review
Oncology
Amir Jassim, Eric P. Rahrmann, Ben D. Simons, Richard J. Gilbertson
Summary: Understanding the combination of cell intrinsic and extrinsic factors in initiating transformation is important for cancer prevention, detection, and early treatment. This review outlines current theories on cancer origins and the underlying determinants of cancer risk. While cancer has been a leading cause of death for decades, controversy remains regarding the transformation of tissues, hindering effective prevention and early intervention. By understanding the complex interplay of cell intrinsic and extrinsic factors, effective strategies for preventing, detecting, and stopping cancer before it becomes incurable can be discovered.
NATURE REVIEWS CANCER
(2023)
Article
Multidisciplinary Sciences
Thomas Chazelle, Michel Guerraz, Richard Palluel-Germain
Summary: Prolonged visual exposure to large bodies leads to a thinning aftereffect, while exposure to thin bodies leads to a fattening aftereffect. This visual adaptation effect may contribute to the association between media exposure and distorted body image perception. A preregistered study was conducted to test the hypothesis that people internalize the distorted image of their body after exposure to thin bodies in the media. The results provided moderate evidence against the hypothesized self-specific effects of mirror exposure on perceptual judgments, suggesting that body size adaptation affects the perception of test stimuli rather than participants' own body image.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Physics, Multidisciplinary
Niles E. Lehman, Stuart. A. Kauffman
Summary: This article explores the origins and evolution of life based on the thermodynamic concept of work cycles, highlighting three significant events that led to life as we know it on Earth, each requiring fundamental changes in the phase space of the system.
Review
Biochemistry & Molecular Biology
Gregor P. Greslehner
Summary: The disciplinary identity of molecular biology has been questioned, but through historical research and philosophical analysis, it can be seen as a viable interdisciplinary program, even without strict boundaries.
Article
Microbiology
Anna Maria Giuliodori, Riccardo Belardinelli, Melodie Duval, Raffaella Garofalo, Emma Schenckbecher, Vasili Hauryliuk, Eric Ennifar, Stefano Marzi
Summary: Escherichia coli CspA is an RNA binding protein that stimulates translation, including its own, during cold-shock. It specifically promotes the translation of cspA mRNA at low temperature by interacting with the folded conformation less accessible to the ribosome without inducing large structural rearrangements. This interaction allows the progression of ribosomes during the transition from translation initiation to elongation, and a similar mechanism may be responsible for CspA-dependent translation stimulation observed with other probed mRNAs.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biology
Jacob T. Polaski, Dylan B. Udy, Luisa F. Escobar-Hoyos, Gokce Askan, Steven D. Leach, Andrea Ventura, Ram Kannan, Robert K. Bradley
Summary: UPF1 mutations are not major functional drivers of PASC, and do not significantly affect pancreatic cancer growth and acquisition of adenosquamous features. Some reported UPF1 mutations may be existing genetic variants in the human population.
Article
Biochemistry & Molecular Biology
Clara-L. Sandmann, Jana F. Schulz, Jorge Ruiz-Orera, Marieluise Kirchner, Matthias Ziehm, Eleonora Adami, Maike Marczenke, Annabel Christ, Nina Liebe, Johannes Greiner, Aaron Schoenenberger, Michael B. Muecke, Ning Liang, Robert L. Moritz, Zhi Sun, Eric W. Deutsch, Michael Gotthardt, Jonathan M. Mudge, John R. Prensner, Thomas E. Willnow, Philipp Mertins, Sebastiaan van Heesch, Norbert Hubner
Summary: This study analyzes the evolutionary origins of 7,264 recently cataloged human short open reading frames (sORFs) and finds that most of them are evolutionarily young and emerged de novo. The researchers also identify 221 previously missed sORFs that potentially encode peptides smaller than the smallest annotated human microprotein. By conducting mass-spectrometry-based interactome screens and cellular assays, the study associates some of these sORFs with mRNA splicing, translational regulation, and endocytosis-related functions.
Review
Biology
Addy Pross
Summary: The central thesis of the modern scientific revolution is that nature is objective, yet projective systems emerged from that objective reality. Chemical systems emerged and evolved to take advantage of nature's objective laws, which were uncovered by nature twice. The challenging question remains: how did nature become self-aware and discover its own laws?
Article
International Relations
Benjamin Miller
Summary: The attempt to promote liberalism worldwide led to the rise of illiberal elements in the West, with both successes like China's economic integration and failures like democracy-promotion in China, Russia, and the Middle East contributing to economic and cultural populism. The integration of China into the international order under US leadership resulted in adverse economic effects in the West, while American interventions in the Middle East fueled terrorism and Muslim migration, influencing the rise of cultural populism in the West.
INTERNATIONAL AFFAIRS
(2021)
Article
International Relations
Benjamin Miller
Summary: The attempt to make the world more liberal ended up making the West less liberal, as reflected in the rise of illiberal elements such as Brexit and Trumpism. The successes and failures in promoting liberalism globally generated populist forces in the West, with economic populism on the rise due to adverse effects of Chinese economic success and cultural populism fueled by American interventions in the Middle East.
INTERNATIONAL AFFAIRS
(2021)
Review
Neurosciences
Sophia C. Levis, Stephen V. Mahler, Tallie Z. Baram
Summary: Opioid use disorder (OUD) is not typically a singular psychiatric condition, with comorbid symptoms likely tied to various risk factors. Early life adversity may disrupt reward circuit development, potentially contributing to OUD and other comorbid neuropsychiatric disorders.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Nonno Hasegawa, Maeva A. Techer, Noureddine Adjlane, Muntasser Sabah al-Hissnawi, Karina Antunez, Alexis Beaurepaire, Krisztina Christmon, Helene Delatte, Usman H. Dukku, Nurit Eliash, Mogbel A. A. El-Niweiri, Olivier Esnault, Jay D. Evans, Nizar J. Haddad, Barbara Locke, Irene Munoz, Gregoire Noel, Delphine Panziera, John M. K. Roberts, Pilar De la Rua, Mohamed A. Shebl, Zoran Stanimirovic, David A. Rasmussen, Alexander S. Mikheyev
Summary: This study used phylogeographic analysis based on whole-genome data to reconstruct the origins and spread of deformed wing viruses (DWV) transmitted by the varroa mite. The results suggest that DWV-A likely originated in East Asia and spread in the mid-20th century, while DWV-B was acquired more recently from a source outside East Asia and appears to be absent from the original varroa host.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Business
Fernando Fstoso, Hector Gonzalez-Jimenez, Teresa Cometto
Summary: Selfie editing is influenced by psychological factors such as low self-esteem, body comparison with peers/models, and cybervictimization, and has consequences on teenagers' social media addiction and life satisfaction. Comparison with peers in terms of body image is the main driver for selfie editing. Additionally, selfie editing is positively associated with social media addiction and negatively associated with life satisfaction, particularly among teens with higher body-image discrepancy.
JOURNAL OF BUSINESS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Armando R. Hernandez, Yaming Shao, Shuichi Hoshika, Zunyi Yang, Sandip A. Shelke, Julien Herrou, Hyo-Joong Kim, Myong-Jung Kim, Joseph A. Piccirilli, Steven A. Benner
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
Article
Chemistry, Multidisciplinary
Saurja DasGupta, Sandip A. Shelke, Nan-sheng Li, Joseph A. Piccirilli
CHEMICAL COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Deepak Koirala, Sandip A. Shelke, Marcel Dupont, Stormy Ruiz, Saurja DasGupta, Lucas J. Bailey, Steven A. Benner, Joseph A. Piccirilli
NUCLEIC ACIDS RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Sandip A. Shelke, Snorri Th Sigurdsson
Review
Chemistry, Organic
Sandip A. Shelke, Snorri Th Sigurdsson
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2012)
Article
Chemistry, Multidisciplinary
Ulla Jakobsen, Sandip A. Shelke, Stefan Vogel, Snorri Th. Sigurdsson
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2010)
Article
Biochemistry & Molecular Biology
Hao Huang, Nikolai B. Suslov, Nan-Sheng Li, Sandip A. Shelke, Molly E. Evans, Yelena Koldobskaya, Phoebe A. Rice, Joseph A. Piccirilli
NATURE CHEMICAL BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Sandip A. Shelke, Snorri Th. Sigurdsson
NUCLEIC ACIDS RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Thomas E. Edwards, Pavol Cekan, Gunnar W. Reginsson, Sandip A. Shelke, Adrian R. Ferre-D'Amare, Olav Schiemann, Snorri Th. Sigurdsson
NUCLEIC ACIDS RESEARCH
(2011)
Article
Biochemistry & Molecular Biology
Gunnar W. Reginsson, Sandip A. Shelke, Christophe Rouillon, Malcolm F. White, Snorri Th. Sigurdsson, Olav Schiemann
NUCLEIC ACIDS RESEARCH
(2013)
Article
Chemistry, Organic
Sandip A. Shelke, Gunnar B. Sandholt, Snorri Th. Sigurdsson
ORGANIC & BIOMOLECULAR CHEMISTRY
(2014)
Article
Multidisciplinary Sciences
Sandip A. Shelke, Yaming Shao, Artur Laski, Deepak Koirala, Benjamin P. Weissman, James R. Fuller, Xiaohong Tan, Tudor P. Constantin, Alan S. Waggoner, Marcel P. Bruchez, Bruce A. Armitage, Joseph A. Piccirilli
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Deepak Koirala, Yaming Shao, Yelena Koldobskaya, James R. Fuller, Andrew M. Watkins, Sandip A. Shelke, Evgeny Pilipenko, Rhiju Das, Phoebe A. Rice, Joseph A. Piccirilli
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Daniel Krochmal, Yaming Shao, Nan-Sheng Li, Saurja DasGupta, Sandip A. Shelke, Deepak Koirala, Joseph A. Piccirilli
Summary: Ribozymes that react with small-molecule probes have important applications in transcriptomics and chemical biology. This study focuses on a self-alkylating ribozyme and reports its crystal structures, showing a hook-shaped conformation.
NATURE CHEMICAL BIOLOGY
(2022)
