Article
Engineering, Environmental
Renjun Yang, Yuanping Lu, Nuoya Yin, Francesco Faiola
Summary: Bisphenol A (BPA), a common endocrine disruptor, induces similar toxic effects across different species and tissues. Exposure to BPA significantly impacts processes like lipid metabolism, proliferation, and apoptosis. The study also reveals key signaling pathways and molecular mechanisms affected by BPA.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Oncology
Ana Galan-Cobo, Christine M. Stellrecht, Emrullah Yilmaz, Chao Yang, Yu Qian, Xiao Qu, Ishita Akhter, Mary L. Ayres, Youhong Fan, Pan Tong, Lixia Diao, Jie Ding, Uma Giri, Jayanthi Gudikote, Monique Nilsson, William G. Wierda, Jing Wang, Ferdinandos Skoulidis, John D. Minna, Varsha Gandhi, John Heymach
Summary: Loss-of-function somatic mutations of STK11, a tumor suppressor gene encoding LKB1, contribute to the aggressive phenotype and altered energy balance of cancer cells. LKB1-deficient tumor cells display enhanced sensitivity to the energy-depleting nucleoside analog 8-Cl-Ado. Targeting the MAPK/MEK/ERK and PI3K/AKT pathways can enhance the antitumor efficacy of 8-Cl-Ado in LKB1-deficient tumor cells.
MOLECULAR CANCER RESEARCH
(2022)
Correction
Emergency Medicine
L. Kolios, M. Hitzler, A. Moghaddam, C. Takur, H. Schmidt-Gayk, B. Hoener, M. Lehnhardt, P. Gruetzner, C. Woelfl
Summary: An error was found in the original version of the article.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2021)
Review
Oncology
Erik Knutsen, Adrian L. Harris, Maria Perander
Summary: NEAT1 is a highly abundant nuclear architectural long non-coding RNA, playing important roles in cellular stress and developmental processes. Abnormal expression of NEAT1 in many cancers may be associated with therapy resistance and poor clinical outcome.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
N. P. Scott, E. J. Teoh, H. Flight, B. E. Jones, J. Niederer, L. Mustata, G. M. MacLean, P. G. Roy, D. D. Remoundos, C. Snell, C. Liu, F. Gleeson, A. L. Harris, S. R. Lord, D. R. McGowan
Summary: In this study, the uptake of F-18-fluciclovine in breast cancer was evaluated using dynamic PET/CT imaging, with a reversible one-tissue compartment model found to best describe tracer uptake. No significant differences were observed in kinetic or static parameters for different breast cancer receptor subtypes or tumor grades. There was a good correlation between kinetic and static parameters.
BRITISH JOURNAL OF CANCER
(2022)
Review
Immunology
Esther Arnaiz, Adrian L. Harris
Summary: In solid tumors, hypoxia induces adaptive mechanisms in tumor cells, promotes immune evasion, resistance to therapies, and affects interferon signaling pathway, highlighting the importance of addressing hypoxic effects for successful cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Kathrin Schilling, Adrian L. Harris, Alex N. Halliday, Christopher J. Schofield, Helen Sheldon, Syed Haider, Fiona Larner
Summary: The study reveals differences in zinc isotope fractionation between in vitro experiments and in vivo breast cancer tissues, suggesting variations in zinc transporter levels or intracellular zinc storage mechanisms as the potential cause.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris, Jaromir Pastorek
Summary: Hypoxia in the tumor microenvironment is a major factor in cancer progression, and low levels of oxygen may indicate treatment failure. Carbonic anhydrase IX (CA IX) is a precise target in hypoxic tumors, and its presence contributes to the failure of standard therapy. Humanized antibodies against CA IX show promise as suitable therapies for hypoxic tumors, with the ability to modulate the tumor microenvironment, induce an immune response, and block metastasis formation.
CANCER & METABOLISM
(2022)
Article
Oncology
Hannah Bolland, Eric Vancauwenberghe, Pamela Collier, Anna M. M. Grabowska, Alan McIntyre, Adrian L. Harris, Christopher Paul Carrol, Alison A. Ritchie, Philip A. Clarke
Summary: Regions of low oxygen are commonly found in breast tumors, especially in the aggressive triple negative subtype. Metastasis is the leading cause of death in breast cancer patients. The expression of Na+ driven bicarbonate transporters (NDBTs) is increased in hypoxic breast cancer, and targeting hypoxia-induced NDBTs can reduce tumor migration, invasion, and metastasis.
Editorial Material
Multidisciplinary Sciences
Philipp Poeller, Almut Schulze
Summary: Mutated forms of Akt protein play a central role in driving cancer metabolism by promoting the synthesis of coenzyme A, thereby broadening our understanding of its activity.
Article
Cell Biology
Christos E. Zois, Anne M. Hendriks, Syed Haider, Elisabete Pires, Esther Bridges, Dimitra Kalamida, Dimitrios Voukantsis, B. Christoffer Lagerholm, Rudolf S. N. Fehrmann, Wilfred F. A. den Dunnen, Andrei I. Tarasov, Otto Baba, John Morris, Francesca M. Buffa, James S. O. McCullagh, Mathilde Jalving, Adrian L. Harris
Summary: This study reveals the significant role of glycogen metabolism in glioblastoma (GBM) cancer. Inhibition of glycogen degradation sensitizes GBM cells to high-dose ionising radiation (IR), suggesting that PYGL may serve as a potential novel target for GBM treatment.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Sunil S. Badve, Sanghee Cho, Xiaoyu Lu, Sha Cao, Soumya Ghose, Aye Aye Thike, Puay Hoon Tan, Idris Tolgay Ocal, Daniele Generali, Fabrizio Zanconati, Adrian L. Harris, Fiona Ginty, Yesim Gokmen-Polar
Summary: The study investigated the prognostic role of tumor-infiltrating lymphocytes (TILs) in ductal carcinoma in situ (DCIS) in multi-national cohorts from Asian and European women. It found that older women with circumferential TILs were less likely to develop second breast cancer events (BCE) at a 5-year follow-up. The spatial arrangement of TILs may serve as a better prognostic indicator in DCIS cases.
Editorial Material
Oncology
Adrian L. Harris
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Tong Yu, Archana Chandrabhan Jadhav, Jiabao B. Xu, Adrian L. L. Harris, Venugopal Nair, Wei E. E. Huang
Summary: Understanding the development of cancer resistance to therapies is crucial. Newcastle disease virus (NDV) is a promising oncolytic agent, but some colon cancer cells show resistance to NDV reinfection. By using Raman spectroscopic and stable isotopic techniques, we found that the resistant cells slow down their replication and divert energy to protein and lipid synthesis. Understanding metabolic reprogramming could aid in developing precision cancer treatments that target resistant cells at the single-cell level.
Article
Oncology
Simon R. Lord, Adrian L. Harris
Summary: Over the past 15 years, there has been extensive interest in repurposing the diabetes drug metformin as a cancer treatment. However, despite numerous large clinical trials in various tumor types, the results have been disappointing. This article summarizes the initial interest in metformin's potential in oncology, the current clinical program, and the lessons learned from this experience regarding further investigation of metformin in cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Soumya Ghose, Sanghee Cho, Fiona Ginty, Elizabeth McDonough, Cynthia Davis, Zhanpan Zhang, Jhimli Mitra, Adrian L. Harris, Aye Aye Thike, Puay Hoon Tan, Yesim Gokmen-Polar, Sunil S. Badve
Summary: The authors developed a deep learning classification network to predict breast cancer events (BCEs) in patients with ductal carcinoma in situ (DCIS), providing early and accurate predictions for personalized therapy and avoiding over-treatment of low-risk patients.
Editorial Material
Oncology
Nicole D. D. Machado, Lisa C. C. Heather, Adrian L. L. Harris, Geoff S. S. Higgins
Summary: The disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, has raised doubts about the justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies. Analyzing the potency, tissue selectivity, and toxicity of these agents can provide insights into the lessons learned from this failure and identify new opportunities.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
G. P. Ralli, R. D. Carter, D. R. McGowan, W-C Cheng, D. Liu, E. J. Teoh, N. Patel, F. Gleeson, A. L. Harris, S. R. Lord, F. M. Buffa, J. D. Fenwick
Summary: In this study, gene set enrichment analysis was performed to identify KEGG pathways associated with FDG uptake in primary breast cancers. Glycolysis/gluconeogenesis pathway and pathways related to immune response or inflammation were found to be associated with FDG uptake. Patlak K, a kinetic parameter, was associated with more pathways than any other imaging index. These results suggest that Patlak analysis of dynamic FDG-PET scans is advantageous for studying tumor biology.
BREAST CANCER RESEARCH
(2022)
