Article
Biochemistry & Molecular Biology
Ziko Milanovic, Dusan Dimic, Milan Zizic, Dejan Milenkovic, Zoran Markovic, Edina Avdovic
Summary: Coumarin derivatives have beneficial biological activities, and two newly synthesized 4,7-dihydroxycoumarin derivatives were found to exhibit antiradical capacity through mechanisms such as HAT and SPLET. EPR results showed a significant reduction in the amount of HO center dot by both compounds, with A-4OH demonstrating better antioxidant capacity than A-3OH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Houssem Boulebd, Imene Amine Khodja
Summary: This study investigated the mechanisms and kinetics of Daphnetin in scavenging free radicals in physiological environments using quantum chemistry calculations, highlighting its different activities in water and lipid media. The theoretical predictions were found to be consistent with experimental data, demonstrating the reliability of the calculations.
Article
Chemistry, Multidisciplinary
Angela Yayun Li, Miguel Melendez-Zamudio, Akop Yepremyan, Michael A. Brook
Summary: Phenolic compounds can undergo radical coupling under oxidizing conditions. By hydrosilylation, silicone oils were modified with eugenol to produce oils and elastomers with antioxidant activity. The physical properties of crosslinked materials, formed by peroxide oxidants at temperatures above 90 degrees C, were correlated with eugenol content, equivalents of peroxide added, and reaction time. The elastomers exhibited efficient antioxidant activity, which was slightly attenuated in higher crosslinked materials due to diverse radical recombination processes.
Article
Chemistry, Physical
Dinh Quy Huong, Mai Van Bay, Pham Cam Nam
Summary: The antioxidant abilities of thiourea derivatives were characterized by measuring the color change of DPPH and ABTS when reacting with the compounds. DPTU exhibited better free radical capture capability compared to BPTU, which was confirmed by quantum chemical calculations. Kinetic calculations revealed that hydrogen atom transfer mechanism is preferred over single electron transfer mechanism when thiourea derivatives react with free radicals, with HAT mechanism accounting for 99.99% of the product amount.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Houssem Boulebd
Summary: This paper systematically studied the antiradical properties of four prenylated natural chalcones and found that the CH bonds of the prenyl substituent are the most thermodynamically preferred sites for free radical attack. Additionally, the OH bonds of the B ring were shown to be more preferred for attacking free radicals than the A ring.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Multidisciplinary Sciences
Khairunisa Mohd Zamli, Asnuzilawati Asari, Kooi Yeong Khaw, Vikneswaran Murugaiyah, Mariya Al-Rashida, Habsah Mohamad, Hanis Mohd Yusoff, Nurul Huda Abdul Wahab, Hasnah Osman
Summary: The study found that most eugenol derivatives had higher inhibitory activities against butyrylcholinesterase (BChE) compared to acetylcholinesterase (AChE), but their overall inhibitory activity was weak. However, three derivatives showed good AChE inhibitory activity at 10 µg/mL, with compound 9 exhibiting the most potent AChE inhibition with an IC50 of 5.64 µg/mL. Additionally, ligand-protein docking simulation was performed for the most active derived molecules (compounds 3, 6, 9).
Article
Biochemistry & Molecular Biology
Yan Zhang, Dongmei Dou, Wei Gu
Summary: The study investigates the fluorination of ferulic acid antioxidant and its effects, revealing that fluorination alters the stability, solubility, and molecular polarity of FA, and increases the non-linear optical response. This research provides an efficient strategy to design new drugs with better pharmacological properties by fluorinating FA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Pharmacology & Pharmacy
Carine Sebaaly, Souha Haydar, Helene Greige-Gerges
Summary: The aim of this study is to investigate the effect of chitosan coating layer and molecular weight on the characteristics of liposomes encapsulating eugenol. The results showed that the presence of chitosan coating layer increased the particle size of liposomes, and increasing chitosan molecular weight led to an increase in cholesterol incorporation. The incorporation rates of phospholipids and eugenol decreased in chitosomes. Chitosomes enhanced the antioxidant activity of eugenol and maintained its encapsulation after long-term storage.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Jingyi Xue, Yaguang Luo, Brindhalakshmi Balasubramanian, Abhinav Upadhyay, Zhenshun Li, Yangchao Luo
Summary: A novel nanocomplex for encapsulating hydrophobic antibacterial compounds was developed by modifying PG and interacting with zein. The nanocomplexes showed small particle size with high zeta potential and significantly improved bioactivity, providing a potential carrier for lipophilic and phenolic antimicrobial compounds in food safety applications.
FOOD HYDROCOLLOIDS
(2021)
Article
Plant Sciences
Yahya Hasan Hobani, Syam Mohan, Emad Shaheen, Aymen Abdelhaleem, Md Faruque Ahmad, Saurabh Bhatia, Alaa Sayed Abou-Elhamd
Summary: Our findings indicated that eugenol has a significant gastroprotective effect at low doses, which can be attributed to its ability to regulate inflammatory reactions and antioxidant capacity. The protective effect of eugenol was enhanced by restoring the lowered GSH and NP-SH levels. Eugenol pre-treatment reduced plasma NO levels and increased PGE2, while decreasing TNF-alpha and IL-6 concentrations. The expression of HSP70 was upregulated and iNOS was downregulated in eugenol-treated rat stomach tissue.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Anes El-hadj Said, Sidi Mohamed Mekelleche
Summary: The study explored the thermodynamic and kinetic aspects of Trolox derivatives reactions with methylperoxyl radical CH3OO· using density functional theory. It found that HAT is the preferred mechanism in lipid media while SPLHAT is the most favored mechanism in water. The calculated rate constants showed that the antioxidant activities of the Trolox derivatives are significantly faster than that of the reference system Trolox.
THEORETICAL CHEMISTRY ACCOUNTS
(2021)
Article
Chemistry, Multidisciplinary
Eman M. Elattar, Amal A. Galala, Hassan-Elrady A. Saad, Farid A. Badria
Summary: Chemical transformation study is an important tool for new drugs discovery. In this study, new eugenol 1,2,3-triazole derivatives were synthesized via click chemistry using the Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition method. Their inhibitory effects on hyaluronidase enzyme were examined, and one derivative showed enhanced inhibitory effect compared to its parent compound eugenol.
Article
Chemistry, Physical
Goncagul Serdaroglu, Nesimi Uludag, Erol Ercag, Paramasivam Sugumar, Parthasarathi Rajkumar
Summary: Various carbazole derivatives were synthesized and characterized, revealing the preferential intermolecular interactions of one compound, the factors contributing to the reduction of stabilization energy, and the highest binding affinity with a human enzyme. Antioxidant properties were also studied, indicating the potential of a specific compound. Additionally, molecular docking calculations were performed on enzymes to further understand the interactions of the synthesized compounds.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Puneet Kaur Randhawa, Aishwarya Rajakumar, Isabela Beatriz Futuro de Lima, Manish K. Gupta
Summary: Despite clinical advances, ischemia-induced cardiac diseases remain a significant cause of death. Epigenetic modifications, specifically alterations in histone acetylation, play a crucial role in counteracting ischemic conditions. Study findings suggest that eugenol, a compound found in various phenolic and non-phenolic compounds, can maintain cellular histone acetylation, decrease reactive oxygen species (ROS), and improve cellular viability during ischemia. Moreover, eugenol regulates certain genes and cellular functions associated with cardiovascular diseases and metabolic processes. Therefore, eugenol shows potential as an agent for protecting ischemic cells and developing novel cardiac disease treatments.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Organic
Achraf Abdou, Sabrine Idouaarame, Mohammed Salah, Nabil Nor, Soukaina Zahm, Abdelhakim El Makssoudi, Noureddine Mazoir, Ahmed Benharref, Abdelmjid Dari, Jamal Jamal Eddine, Mohamed Blaghen, Mohamed Dakir
Summary: This study evaluated the antimicrobial and antioxidant activities of eugenol and its derivatives through molecular dynamic simulation, and tested them against Escherichia coli and Staphylococcus aureus. The results revealed the potential inhibitory effects of these compounds against the two bacteria, with epoxyeugenol being the most active antioxidant.
LETTERS IN ORGANIC CHEMISTRY
(2022)
