Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 20, Pages 1911-1916Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.790029
Keywords
Catharanthus roseus; vinblastine-type N-oxide alkaloids; cytotoxicity
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Funding
- National Natural Science Foundation of China [81102343, 30901998, 81274115]
- Program for New Century Excellent Talents in University [NCET-11-0606]
- Program of Science & Technology New Star of Beijing City [2009A35]
- Ministry of Science and Technology of China [2011DFA31860, 2012ZX09103201]
- National Natural Science Funds for Distinguished Young Scholar [30625039]
- Program for Changjiang Scholars
- Natural Science Foundation of Guangdong Province [8351063201000003]
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Two new vinblastine-type N-oxide alkaloids, 17-desacetoxyvinblastine N-b'-oxide (1) and 20-deoxyvinblastine N-b'-oxide (2), were isolated from the leaves of Catharanthus roseus. The structures of 1 and 2 were established by the analysis of their nuclear magnetic resonance and HR-ESI-MS spectroscopic data. All alkaloids were evaluated for their cytotoxic activities against the human hepatocellular carcinoma (HepG2) cell line, human colorectal carcinoma (Lovo) cell line and human breast carcinoma (MCF-7) cell line by the MTT method in vitro, respectively. The results showed that cytotoxic activities of alkaloids 1 and 2 exhibited moderate inhibitory activity on the proliferation of three cancer cells.
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