Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 4-5, Pages 480-485Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.696254
Keywords
leishmaniasis; Plumbago zeylanica; naphthoquinone; antileishmanial activity
Categories
Funding
- Department of Science and Technology, New Delhi
- Banaras Hindu University
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Leishmania donovani, an obligate intracellular parasite of genus Leishmania causes visceral leishmaniasis that affects millions of people worldwide, especially in the Indian subcontinent and East Africa. Generic pentavalent antimonials have been the mainstay for therapy in the endemic regions due to efficacy and cost effectiveness but the growing incidence of their resistance has seriously hampered their use. This study discloses strong invitro antileishmanial activity of 2-methyl-5-(3-methyl-but-2-enyloxy)-[1,4]naphthoquinone (1), a prenyloxy-naphthoquinone isolated and characterised from roots of the plant Plumbago zeylanica (family Plumbaginaceae). The observed EC50 for the compound 1 against promastigote and amastigote forms of L. donovani was significantly (p<0.001) lower than miltefosine, a reference drug. In context to limited treatment options and growing resistance for available drugs, compound 1 offers a greater prospect towards antileishmanial drug discovery and development.
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