Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 24, Pages 2304-2310Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.828292
Keywords
Adiantum capillus-veneris; Adiantaceae; triterpenoids
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Funding
- CSIR
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Two new triterpenoids characterised as 30-normethyl fernen-22-one (capillirone, 1) and hopan-3-ol (capillirol B, 2), along with two known triterpenoids, 4--hydroxyfilican-3-one and 3-,4--dihydroxyfilicane, have been isolated from the ethanolic extract of the fronds of Adiantum capillus-veneris Linn. (Adiantaceae). Compounds 1 and 3 showed significant anti-inflammatory activity with 33.07% (p<0.01) and 42.30% (p<0.001) inhibition as compared to indomethacin that exhibited 60.00% (p<0.001) inhibition after 3h in the carrageenan-induced hind paw oedema method. Compound 3 showed potent anti-nociceptive activity with 42.37% inhibition as compared to indomethacin that showed 45.34% inhibition in the writhing test.
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