Journal
NATURAL PRODUCT RESEARCH
Volume 27, Issue 17, Pages 1556-1561Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.738204
Keywords
Machaerium hirtum; flavonoid; alkaloid; triterpene; steroid
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Funding
- CNPq
- CAPES
- UEM
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Leaves and branches of Machaerium hirtum Vell. (Fabaceae), native to South America, were subjected to phytopharmacological investigation in order to identify its major chemical constituents and evaluate its extracts, fractions and isolated compounds in assays for anti-inflammatory activities. These were performed using mouse ear edema model, pleurisy and myeloperoxidase activity assays. Six compounds were isolated and identified as the flavanones swertisin and isovitexin, the alkaloid 4-hydroxy-N-methylproline, the triterpenes friedelin and lupeol, and the steroids sitosterol and stigmasterol. These compounds were identified by nuclear magnetic resonance of H-1 and C-13 data, in comparison with literature.
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