Article
Chemistry, Analytical
Fabrine Silva Alves, Jorddy Neves Cruz, Ingryd Nayara de Farias Ramos, Dayse Lucia do Nascimento Brandao, Rafael Nascimento Queiroz, Glauce Vasconcelos da Silva, Gleice Vasconcelos da Silva, Maria Fani Dolabela, Marcondes Lima da Costa, Andre Salim Khayat, Jose de Arimateia Rodrigues do Rego, Davi do Socorro Barros Brasil
Summary: This study evaluated the antimicrobial activity and cytotoxicity of black pepper extracts and piperine, and found that they have important antimicrobial, anti-inflammatory, and antioxidant properties.
Article
Green & Sustainable Science & Technology
Syed Aflatun Kabir Hemel, Mohammad Kamrul Hasan, Md. Abdul Wadud, Rojina Akter, Nasima Akther Roshni, Md. Tariqul Islam, Afsana Yasmin, Keya Akter
Summary: Agroforestry is a significant aspect of rural farmers' socioeconomic and livelihood situation. This research focuses on the impact of agroforestry, specifically Piper chaba-based agroforestry, on the livelihood of farmers in Rajarhat Upazila, Bangladesh. The findings reveal that this system has improved the sustainability of farmers' livelihoods by providing essential resources. However, there are still major problems that need to be addressed to further enhance their livelihoods.
Article
Chemistry, Medicinal
Carolyne Chepkirui, Purity J. Ochieng, Biswajyoti Sarkar, Aabid Hussain, Chiranjib Pal, Li Jun Yang, Paolo Coghi, Hoseah M. Akala, Solomon Derese, Albert Ndakala, Matthias Heydenreich, Vincent K. W. Wong, Mate Erdelyi, Abiy Yenesew
Summary: Five compounds were isolated from the leaves of Mundulea sericea, with three additional compounds isolated from the roots. Compound 1 showed good antiplasmodial activity, while compounds 2 and 5 exhibited activity against drug-sensitive Leishmania donovani. Compound 3 showed significant cytotoxicity against human cell lines, while the other compounds displayed low cytotoxicity.
Article
Chemistry, Medicinal
Julyanne Maria Saraiva de Sousa, Thais Amanda de Lima Nunes, Raiza Raianne Luz Rodrigues, Joao Paulo Araujo de Sousa, Maria da Conceicao Albuquerque Val, Francisco Alex da Rocha Coelho, Airton Lucas Sousa dos Santos, Nicolle Barreira Maciel, Vanessa Maria Rodrigues de Souza, Yasmim Alves Aires Machado, Paulo Sergio de Araujo Sousa, Alyne Rodrigues de de Araujo, Jefferson Almeida Rocha, Damiao Pergentino de Sousa, Marcos Vinicius da Silva, Daniel Dias Rufino Arcanjo, Klinger Antonio da Franca Rodrigues
Summary: The aim of this study was to evaluate the activity, cytotoxicity, and potential mechanisms of action of beta-ocimene against Leishmania amazonensis. Beta-ocimene showed direct activity against the parasite and had higher activity against intra-macrophagic amastigotes. The results suggest that beta-ocimene has promising potential as a candidate drug for the treatment of leishmaniasis.
Article
Biology
Mohammad Mahfuzur Rahman, Tyeaba Tasnim Dipti, M. Nazrul Islam, Abu Tareq Mohammad Abdullah, Sharmin Jahan, Md. Morshedul Alam, M. Rezaul Karim
Summary: This study examined the suitability of Piper chaba, a traditional medicinal herb and curry spice, as a natural preservative for beef products. The results showed significant antioxidant and antibacterial activities of Piper chaba extracts. Furthermore, the study demonstrated that Piper chaba extracts could effectively preserve the quality and stability of beef products during storage.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Infectious Diseases
Mariana B. C. Brioschi, Elizabeth M. Coser, Adriano C. Coelho, Fernanda R. Gadelha, Danilo C. Miguel
Summary: A growing number of studies have shown the potential of numerous antileishmanial candidates in vitro. However, the lack of uniformity in cell type selection for cytotoxicity assays may result in incomparable and inconclusive data. Standardized preclinical testing protocols are needed to evaluate new antileishmanial candidates.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Infectious Diseases
Mariana B. C. Brioschi, Elizabeth M. Coser, Adriano C. Coelho, Fernanda R. Gadelha, Danilo C. Miguel
Summary: Recent studies have shown the in vitro potential of antileishmanial candidates, but lack of uniformity in cell type selection for cytotoxicity assays leads to incomparable and inconclusive data. Establishing standardized protocols for evaluating new antileishmanial candidates is necessary.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Chemistry, Medicinal
Daisy K. Mangwegape, Nonkululeko H. Zuma, Janine Aucamp, David D. N'Da
Summary: Leishmaniasis is a major parasitic disease affecting tropical and subtropical developing countries, with limited treatment options. Through in vitro experiments with benzothiadiazine derivatives, it was found that these compounds have potential as antileishmanial agents by showing activity against parasites and no toxicity to mammalian cells.
ARCHIV DER PHARMAZIE
(2021)
Article
Biochemistry & Molecular Biology
Sandra Ramos-Inza, Andreina Henriquez-Figuereo, Esther Moreno, Melibea Berzosa, Ignacio Encio, Daniel Plano, Carmen Sanmartin
Summary: In this study, a series of selenium-containing compounds were designed and synthesized, and their antiproliferative, antileishmanial, and antibacterial activities were evaluated in vitro. Some of these compounds showed promising therapeutic potential against multiple pathologies, making them attractive candidates for drug development.
Article
Chemistry, Applied
Amany Hamouda Mahmoud, Basma Khalaf Mahmoud, Mamdouh Nabil Samy, Mostafa Ahmad Fouad, Mohamed Salah Kamel, Katsuyoshi Matsunami
Summary: The bioactivity-guided fractionation of the leaves of Tabebuia aurea resulted in the identification of ethyl acetate fraction with cytotoxic and antileishmanial activity. Five triterpenes and one triterpenoid glucoside were isolated from this fraction. Compound 1 showed cytotoxic activity against multiple cell lines, while compounds 1 and 2 exhibited antileishmanial activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Aziz Ullah Khan, Hidayat Ullah Khan, Munirah Sulaiman Othman Alhar, Shahnaz, Kamran Tahir, Zainab M. Almarhoon, Magdi E. A. Zaki, Salman Latif, Afzal Shah, Afaq Ullah Khan
Summary: In this study, Fe2O3 and ZnO nanoparticles were synthesized from an aqueous extract of T. glabra. The nanoparticles exhibited antimicrobial and antioxidant activities, as well as antileishmanial effects.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Saira Khatoon, Aiman Aroosh, Arshad Islam, Saima Kalsoom, Faisal Ahmad, Shahid Hameed, Sumra Wajid Abbasi, Masoom Yasinzai, Muhammad Moazzam Naseer
Summary: Novel coumarin-incorporated isatin hydrazones were synthesized and evaluated as potent antileishmanial agents, with three compounds showing high activity and biocompatibility in vitro experiments against Leishmania tropica.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Armelle T. Mbaveng, Brice E. N. Wamba, Gabin T. M. Bitchagno, Simplice Beaudelaire Tankeo, Ilhami Celik, Brice C. K. Atontsa, Antoine H. Nkuete Lonfouo, Victor Kuete, Thomas Efferth
Summary: Piper capense is a medicinal spice with potential cytotoxic effects against various cancer cell lines, especially compound 2 and PCFb, which induce apoptosis in cancer cells. These findings suggest that Piper capense could be explored further for developing new drugs to combat malignancies.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Christina Kannigadu, Janine Aucamp, David D. N'Da
Summary: Leishmaniasis is a parasitic disease that lacks an effective vaccine, and the limited treatment options are hindered by drug-resistant strains. Investigation of benzyl analogues of a clinical antibiotic showed promising antileishmanial activity against various Leishmania strains. This research suggests the potential for new antileishmanial agents.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Plant Sciences
Samina Rubnawaz, Mohammad K. Okla, Nosheen Akhtar, Imdad Ullah Khan, Muhammad Zeeshan Bhatti, Hong-Quan Duong, Mohamed A. El-Tayeb, Yahaya B. Elbadawi, Khalid S. Almaary, Ihab M. Moussa, Zahid Khurshid Abbas, Bushra Mirza
Summary: The study confirmed that transgenic Ajuga bracteosa plants have higher metabolic content and stronger biological activities. Among them, ABRL3 showed the highest antibacterial, anticancer, and antiparasitic activities, as well as high toxicity against human cancer cell lines.
Article
Integrative & Complementary Medicine
Md. Imdadul Haque, A. B. M. Alauddin Chowdhury, Md. Shahjahan, Md. Golam Dostogir Harun
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Chemistry, Applied
Ronok Zahan, Md. Sifat Rahi, Md. Chanmiya Sheikh, Ryuta Miyatake, Ennio Zangrando, Tarannum Naz, Md. Al-Amin-Al-Azadul Islam, Md Abu Reza
APPLIED ORGANOMETALLIC CHEMISTRY
(2019)
Article
Obstetrics & Gynecology
Sanjit Roy, Md. Aminul Haque
BMC PREGNANCY AND CHILDBIRTH
(2018)
Article
Public, Environmental & Occupational Health
Md Rabiul Haque, Nick Parr, Salut Muhidin
SOCIAL SCIENCE & MEDICINE
(2019)
Article
Multidisciplinary Sciences
Md Imdadul Haque, A. B. M. Alauddin Chowdhury, Muhammad Shaikh Hassan, Hafiz T. A. Khan, Md Golam Dostogir Harun
Article
Chemistry, Applied
Ronok Zahan, Sinthyia Ahmed, Tahmida Sharmin, Mohammad A. Halim, Md. Sifat Rahi, Md. Chanmiya Sheikh, Ryuta Miyatake, Ennio Zangrando, Tarannum Naz, Md. Al-Amin-Al-Azadul Islam, Md Abu Reza
Summary: The synthesized nickel(II) complex demonstrated inhibitory effects on Ehrlich ascites carcinoma cells by regulating the expression of multiple apoptotic genes, suggesting its potential as a compound for cancer treatment. Both experimental and computational studies confirmed the compound's ability to successfully inhibit EAC cell growth, highlighting its promising role in anticancer therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
Alam Khan, T. M. Fahad, Md Imran Nur Manik, Hazrat Ali, Md. Ashiquazzaman, Md Ibrahim Mollah, Tanjeena Zaman, Md Shariful Islam, Moizur Rahman, Aminur Rahman, Mostafizur Rahman, Tarannum Naz, Mahmud Arif Pavel, Md. Nuruzzaman Khan
Article
Cell Biology
Alam Khan, Tanjeena Zaman, Talukdar Mohammad Fahad, Tanjima Akther, Md Faruk Hasan, Tarannum Naz, Shuji Kishi
Summary: Carbofuran, a broad-spectrum synthetic pesticide, induces oxidative stress in non-target mammals, impacting cellular autophagy and senescence. The mutation of Spinster homolog 1 (Spns1) accelerates cellular senescence. Carbofuran affects autophagic lysosomal biogenesis and down-regulates Nrf2 and Gstp1 expressions.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Plant Sciences
Rayan Al Omar, Rachael Micklewright, Kalpa Masud, Tarannum Naz, Subramanyam Vemulpad, Joanne Jamie
Summary: This review provides a comprehensive account of the customary uses, phytochemistry, and biological activities of plants from the Alphitonia Reissek ex Endl. genus. It emphasizes the significance of Indigenous knowledge systems. The existing research shows a good correlation between the biological activities and phytochemistry of the studied plants and their customary medicinal uses. However, further studies are needed, as more than half of the genus's plants, including those with known customary medicinal uses, have had limited or no biological activities or phytochemistry research conducted. This highlights the potential for further investigation of the ethnopharmacological uses and therapeutic potential of Alphitonia plants.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tabassum Jannat, Md Jamal Hossain, Ahmed M. El-Shehawi, Md Ruhul Kuddus, Mohammad A. Rashid, Sarah Albogami, Ibrahim Jafri, Mohamed El-Shazly, Mohammad Rashedul Haque
Summary: This study investigated the phytochemical and pharmacological properties of Wrightia coccinea. Several compounds were isolated from the bark and seed pulp extracts, showing potential antioxidant, anti-diarrheal, hypoglycemic, and analgesic activities. Computational studies further supported these findings. W. coccinea could be a valuable natural source for managing oxidative stress, diarrhea, hyperglycemia, and pain.
Article
Polymer Science
Md. Sohel Rana, Md. Abdur Rahim, Md. Pervez Mosharraf, Md. Fazlul Karim Tipu, Jakir Ahmed Chowdhury, Mohammad Rashedul Haque, Shaila Kabir, Md. Shah Amran, Abu Asad Chowdhury
Summary: In this study, cellulose nanocrystals (CNCs) were successfully extracted from waste jute fibers through sulfuric acid hydrolysis and characterized. The CNCs obtained after 45 minutes of acid hydrolysis showed high crystallinity and stability. This easy-to-reproduce method provides an efficient way to produce CNCs from waste jute fibers.
Article
Integrative & Complementary Medicine
Safaet Alam, Mohammad A. Rashid, Md. Moklesur Rahman Sarker, Nazim Uddin Emon, Mohammad Arman, Isa Naina Mohamed, Mohammad Rashedul Haque
Summary: The methanol soluble extract of Colocasia gigantea showed potential antidiarrheal, antimicrobial, and antioxidant properties, indicating it may be a safe source for alleviating diarrhea and exploring new medicinal products in the future. In silico studies also supported the efficacy of the compounds in molecular docking analysis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Pharmacology & Pharmacy
Mohammad Rashedul Haque, Mirazul Islam, Md. Ruhul Kuddus
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Geochemistry & Geophysics
Dewan Mohammad Enamul Haque, Sara Hanan Chowdhury, Nawar Wadud Khan
PURE AND APPLIED GEOPHYSICS
(2020)
Article
Public, Environmental & Occupational Health
Budi Aji, Shafiu Mohammed, Md Aminul Haque, Manuela De Allegri
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
(2017)
