Journal
NATURAL PRODUCT RESEARCH
Volume 23, Issue 18, Pages 1719-1730Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410802223778
Keywords
N,N '-diaryl unsymmetrically substituted thiourea derivatives; phytotoxicity; cytotoxicity; acetylcholinesterase activity; butrylcholinesterase activity
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Fourteen N,N'-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic ( in vitro), phytotoxic ( in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference.
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