Article
Plant Sciences
Detelina Petrova, Uros Gasic, Lyubomira Yocheva, Anton Hinkov, Zhenya Yordanova, Ganka Chaneva, Desislava Mantovska, Momchil Paunov, Lyubomira Ivanova, Mariya Rogova, Kalina Shishkova, Daniel Todorov, Anita Tosheva, Veneta Kapchina-Toteva, Valya Vassileva, Atanas Atanassov, Danijela Misic, Georgi Bonchev, Miroslava Zhiponova
Summary: This study characterized the taxonomic position of Nepeta nuda using DNA barcoding and explored its metabolic adjustment and immune activities under different environments. The results showed that wild-grown and in vitro cultivated plants had different phenolic compound contents and immune activities. The antimicrobial potential remained consistent regardless of growth conditions. Analysis of the plant extracts identified 63 compounds, including phenolic acids, flavonoids, and iridoids. Cultivation under different light conditions affected the content of bioactive compounds. Overall, this study provides valuable insights into the regulation of N. nuda productivity and its potential biotechnological applications.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Medicinal
Taghreed A. Ibrahim, Mostafa M. Hegazy, Galal T. Maatooq, Atef A. El-Hela
Summary: The metabolic profiling and biological activity assessment of Stellaria pallida revealed that it contains abundant active compounds and has high medicinal value. The methanol extract showed significant scavenging activity against free radicals and chelating capacity towards iron ions. It also exhibited selective cytotoxicity against various cancer cells and broad-spectrum antiviral activity.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Food Science & Technology
Qinzhang Jiang, Shengwei Wang, Yuzhe Yang, Jinxin Luo, Ruili Yang, Wu Li
Summary: In this study, rice bean was extracted using different methods to determine its polyphenol content. Base hydrolysis was found to be the most effective method for extracting bound polyphenols from rice bean, which contributed to 71.15% of the total phenolic content. A total of 35 individual phenolics were identified in rice bean, with different phenolic compositions in the free and bound fractions. The bound phenolics from base hydrolysis exhibited superior antioxidant activity compared to other extraction methods. These findings suggest that the bound fraction of rice bean should be considered when assessing its potential health benefits.
Article
Biochemistry & Molecular Biology
Juan Su, Xiong Fu, Qiang Huang, Guang Liu, Chao Li
Summary: The aim of this study was to investigate the liberation and phytochemical profile of bound polyphenols present in dietary fiber isolated from Rosa roxburghii fruit pomace, and to explore their biological activity and prebiotic potential. The results showed that the bound polyphenols were released during colonic fermentation at a higher ratio compared to gastrointestinal digestion, and they exhibited antioxidant and alpha-glucosidase inhibitory activity. Furthermore, the study demonstrated that the dietary fiber had a stronger prebiotic effect, promoting the growth of beneficial bacteria and the production of short chain fatty acids. The bound polyphenols may serve as important functional food ingredients in Rosa roxburghii fruit pomace.
Article
Plant Sciences
Kadidiatou O. Ndjoubi, Rajan Sharma, Jelili A. Badmus, Ayesha Jacobs, Audrey Jordaan, Jeanine Marnewick, Digby F. Warner, Ahmed A. Hussein
Summary: Plectranthus madagascariensis, a medicinal plant native to South Africa, has shown potential in the treatment of tuberculosis and psoriasis due to its bioactive compounds with antimicrobial and antioxidant properties. The phytochemical studies of this plant led to the isolation of five known royleanone abietanes, which showed promising results in inhibiting Mycobacterium tuberculosis and demonstrating comparable toxicity to tamoxifen against HaCaT cells. The plant is considered an important ethnomedicinal plant and a promising source of diterpenoids for potential therapeutic applications.
Review
Nutrition & Dietetics
Hilal Yilmaz, Busra Gultekin Subasi, Hasan Ufuk Celebioglu, Tugba Ozdal, Esra Capanoglu
Summary: The interaction of plant phytochemicals with proteins, particularly microbial proteins, has gained research interest due to its potential effects on human health, such as increased antioxidant properties and antimicrobial capabilities. This review collects and analyzes recent data on protein-phenolic interactions, providing insights into their biological activities and potential applications in medical and nutritive approaches.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Applied
Gabriela Boscariol Rasera, Francielle Miranda de Matos, Anna Paula de Souza Silva, Severino Matias de Alencar, Raquel Bridi, Adriano Costa de Camargo, Ruann Janser Soares de Castro
Summary: Germination has been found to improve the antioxidant properties of mustard by increasing the bio-accessibility of phenolic compounds. In this study, the in vitro digestion process was simulated to evaluate the impact of germination on mustard phenolic bio-accessibility. Liquid chromatography-mass spectrometry analysis identified resveratrol, formononetin, and cryptochlorogenic acid as key phenolic compounds. Results showed that digestion positively affected the antioxidant potential of soluble phenolics, although it appeared to negate the improvement caused by germination. However, germinated digested mustard had significantly higher concentrations of sinapic acid compared to non-germinated.
Article
Food Science & Technology
Marianela Desiree Rodriguez, Joaquin Garcia-Cordero, Diana Suarez-Coca, Maria Luisa Ruiz del Castillo, Gracia Patricia Blanch, Sonia de Pascual-Teresa
Summary: Grapes are a rich source of polyphenols in the Mediterranean diet and can provide antioxidants to the human diet. The market for seedless grape varieties has been rapidly growing, but these varieties are not well characterized yet. This study investigated the impact of grape variety on composition and absorbable fraction after in vitro digestion. Results showed that black and red varieties have the potential to increase antioxidant content in the diet. Furthermore, all polyphenols, except flavanols, see a reduction in their bioavailable fraction under in vitro conditions.
Article
Biochemistry & Molecular Biology
Lukasz Swiatek, Elwira Sieniawska, Kouadio Ibrahime Sinan, Gokhan Zengin, Anastazja Boguszewska, Benita Hryc, Kouadio Bene, Malgorzata Polz-Dacewicz, Stefano Dall'Acqua
Summary: This study investigated the chemical profiles and biological properties of Justicia secunda extracts obtained using different solvents. Over 50 compounds, including flavonoids, phenolic acids, and alkaloids, were identified using LC-MS. The methanol and water extracts showed higher phenolic and flavonoid contents and stronger antioxidant abilities. The dichloromethane and ethyl acetate extracts exhibited greater activity against alpha-amylase and alpha-glucosidase. The aqueous extracts demonstrated selective anticancer properties and the methanolic extract decreased the infectious titer and viral load of human herpesvirus type-1. Overall, J. secunda could be used as a multifunctional bioactive raw material for managing diseases related to oxidative stress.
Article
Biochemistry & Molecular Biology
Lingmin Dai, Ke Zhong, Yan Ma, Xiaoqian Cui, Yuhang Sun, Ang Zhang, Guomin Han
Summary: Acetaldehyde plays a critical role in modifying the phenolic profile of red wine during aging and the acetaldehyde-mediated condensation may be responsible for the variation of antioxidant activity. The study found that the disappearance of monomeric phenolics and the formation of polymeric phenolics induced by acetaldehyde can be divided into two phases, with the second phase significantly reducing the antioxidant activity of wine. Controlling the level of acetaldehyde allows for prolonged biological activity during wine aging.
Article
Chemistry, Applied
Shutian Wu, Danyu Shen, Ruohui Wang, Qingyang Li, Runhong Mo, Yuewen Zheng, Ye Zhou, Yihua Liu
Summary: The majority of phenolic compounds in walnut kernels exist in the free form, showing high radical scavenging activity. There is a strong correlation between the antioxidant activities of phenolics and their contents. Acetone is effective for extracting soluble phenolics, while methanol is better for extracting insoluble bound phenolics.
Article
Biochemistry & Molecular Biology
Ahmed M. Saleh, Walid M. Abu El-Soud, Modhi O. Alotaibi, Gerrit T. S. Beemster, Afrah E. Mohammed, Hamada AbdElgawad
Summary: The application of chitosan nanoparticles (CSNPs) can enhance the symbiosis between arbuscular mycorrhizae fungi (AMF) and wheat, leading to improved growth, physiology, and metabolism in the plant. CSNPs treatment increased AMF colonization, auxin and strigolactone levels, and flavonoid exudation in the roots. This, in turn, resulted in higher plant biomass production, photosynthetic rate, and accumulation of health promoting compounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Food Science & Technology
Trang H. D. Nguyen, Danh C. Vu
Summary: Walnuts are oil nuts that are rich in fatty acids and phytochemicals, which provide antioxidant, anti-inflammatory, and cholesterol-lowering properties. Including walnuts in the diet can delay the onset of neurodegenerative disorders and protect against certain cancers. The levels of phytochemicals in walnuts are influenced by agronomic practices and environmental conditions.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Plant Sciences
A. Nizar Ahamed, S. Mohamed Yaser, S. Mohammad Idhris, M. Syed Ali Padusha, N. Ahamed Sherif
Summary: Plectranthus is a genus in the family Lamiaceae with a long history in traditional medicine and a rich composition of secondary metabolites. It exhibits various biological activities such as antibacterial, antifungal, antioxidant, anti-inflammatory, and anticancer properties. This study aims to bridge the knowledge gap, stimulate research attention, and explore opportunities in drug discovery. The abundant pharmaceutical potential of this genus may lead to the development of beneficial drugs for human welfare, although some species are still not thoroughly investigated.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Joana M. Andrade, Eva Maria Dominguez-Martin, Marisa Nicolai, Celia Faustino, Luis Monteiro Rodrigues, Patricia Rijo
Summary: The study found that extracts from Plectranthus spp. plants have antioxidant and inhibitory effects on skin-related enzymes, with certain isolated compounds showing significant activity against tyrosinase and elastase.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
I. Coutinho, G. Pereira, M. F. Simoes, M. Corte-Real, J. Goncalves, L. Saraiva
BIOCHEMICAL PHARMACOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Patricia Rijo, M. Fatima Simoes, A. Paula Francisco, Rosario Rojas, Robert H. Gilman, Abraham J. Vaisberg, Benjamin Rodriguez, Cristina Moiteiro
CHEMISTRY & BIODIVERSITY
(2010)
Article
Plant Sciences
Olga Burmistrova, M. Fatima Simoes, Patricia Rijo, Jose Quintana, Jaime Bermejo, Francisco Estevez
JOURNAL OF NATURAL PRODUCTS
(2013)
Article
Biochemistry & Molecular Biology
Patricia Rijo, Maria Fatima Simoes, Aida Duarte, Benjamin Rodriguez
Article
Plant Sciences
Maria Fatima Simoes, Patricia Rijo, Aida Duarte, Diogo Matias, Benjamin Rodriguez
PHYTOCHEMISTRY LETTERS
(2010)
Article
Plant Sciences
Maria Fatima Simoes, Patricia Rijo, Aida Duarte, Diana Barbosa, Diogo Matias, Joana Delgado, Nadia Cirilo, Benjamin Rodriguez
PHYTOCHEMISTRY LETTERS
(2010)
Article
Chemistry, Medicinal
Patricia Rijo, Aida Duarte, Ana Paula Francisco, Teresa Semedo-Lemsaddek, Maria Fatima Simoes
PHYTOTHERAPY RESEARCH
(2014)
Article
Plant Sciences
C Gaspar-Marques, P Rijo, MF Simeoes, MA Duarte, B Rodriguez
Article
Plant Sciences
C Gaspar-Marques, MF Simoes, B Rodríguez
JOURNAL OF NATURAL PRODUCTS
(2005)
Article
Chemistry, Multidisciplinary
P Rijo, MF Simoes, B Rodríguez
MAGNETIC RESONANCE IN CHEMISTRY
(2005)
Article
Plant Sciences
C Gaspar-Marques, MF Simoes, B Rodríguez
JOURNAL OF NATURAL PRODUCTS
(2004)
Article
Plant Sciences
C Gaspar-Marques, MF Simoes, A Duarte, B Rodríguez
JOURNAL OF NATURAL PRODUCTS
(2003)
Article
Chemistry, Medicinal
Patricia Rijo, Benjamin Rodriguez, Aida Duarte, M. Fatima Simoes
NATURAL PRODUCTS JOURNAL
(2011)
Article
Biochemistry & Molecular Biology
Patricia Rijo, Cristina Gaspar-Marques, Maria F. Simoes, Maria L. Jimeno, Benjamin Rodriguez
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2007)
