α-Haloaldehydes: versatile building blocks for natural product synthesis

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

A General, Enantioselective Synthesis of Protected Morpholines and Piperazines

(2012) Matthew C. O’Reilly et al.   ORGANIC LETTERS

Enantioselective Synthesis of Spiroacetals via Silver(I)-Promoted Alkylation of Hemiacetals: Total Synthesis of Cephalosporolides E and F

(2012) Stanley Chang et al.   ORGANIC LETTERS

Synthesis of 2,3-dicarbonylated pyrroles and furans via the three-component Hantzsch reaction

(2012) Thomas A. Moss et al.   TETRAHEDRON LETTERS

Cyclopropyl Iminium Activation: Reactivity Umpolung in Enantioselective Organocatalytic Reaction Design

(2011) Christof Sparr et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transforming terpene-derived aldehydes into 1,2-epoxides via asymmetric α-chlorination: subsequent epoxide opening with carbon nucleophiles

(2011) Philipp Winter et al.   CHEMICAL COMMUNICATIONS

A General Strategy for the Stereocontrolled Preparation of Diverse 8- and 9-MemberedLaurencia-Type Bromoethers

(2011) Scott A. Snyder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Organocatalytic Cross-Aldol Reaction between Aliphatic Aldehydes through Their Functional Differentiation

(2011) Taichi Kano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid, One-Pot Synthesis of β-Siloxy-α-haloaldehydes

(2011) Jakub Saadi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diasteroselective Preparation of Cyclopropanols Using Methylene Bis(iodozinc)

(2011) Kevin Cheng et al.   ORGANIC LETTERS

Asymmetric Total Synthesis of (+)-Danicalipin A

(2011) Takehiko Yoshimitsu et al.   ORGANIC LETTERS

Highly Enantioselective One-Pot Copper-Catalyzed 1,4 Addition/Organocatalyzed α-Substitution of Enals

(2010) Adrien Quintard et al.   ADVANCED SYNTHESIS & CATALYSIS

Discovery of novel sphingosine kinase-1 inhibitors. Part 2

(2010) Yibin Xiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Direct asymmetric bromination of aldehydes catalyzed by a binaphthyl-based secondary amine: highly enantio- and diastereoselective one-pot synthesis of bromohydrins

(2010) Taichi Kano et al.   CHEMICAL COMMUNICATIONS

Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres

(2010) Adrien Quintard et al.   CHEMICAL COMMUNICATIONS

Mukaiyama aldol addition to α-chloro-substituted aldehydes. Origin of the unexpected syn selectivity

(2010) Tessie Borg et al.   CHEMICAL COMMUNICATIONS

Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation

(2010) David G. I. Kingston   JOURNAL OF NATURAL PRODUCTS

Stereoselective Synthesis of Chiral 4-(1-Chloroalkyl)-β-Lactams Starting from Amino Acids and Their Transformation into Functionalized Chiral Azetidines and Pyrrolidines

(2010) Stijn Dekeukeleire et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Total Synthesis of (+)-Hexachlorosulfolipid, a Cytotoxin Isolated from Adriatic Mussels

(2010) Takehiko Yoshimitsu et al.   JOURNAL OF ORGANIC CHEMISTRY

Complex synthesis yields breast-cancer therapy

(2010) Heidi Ledford   NATURE

General Access to ChiralN-Alkyl Terminal Aziridines via Organocatalysis

(2010) Olugbeminiyi O. Fadeyi et al.   ORGANIC LETTERS

A Concise and Stereoselective Synthesis of Hydroxypyrrolidines: Rapid Synthesis of (+)-Preussin

(2010) Jason A. Draper et al.   ORGANIC LETTERS

Regioselective and Stereoselective Cyclizations of Chloropolyols in Water: Rapid Synthesis of Hydroxytetrahydrofurans

(2010) Baldip Kang et al.   ORGANIC LETTERS

Organocatalytic Enantioselective Olefin Aminofluorination

(2010) Chandrakumar Appayee et al.   ORGANIC LETTERS

The strategic marriage of method and motif. Total synthesis of varitriol

(2010) Matthew Brichacek et al.   TETRAHEDRON

Achieving Molecular Complexity by Organocatalytic One-Pot Strategies-A Fast Entry for Synthesis of Sphingoids, Amino Sugars, and Polyhydroxylated α-Amino Acids

(2009) Hao Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Linchpin Catalysis by SOMO Catalysis: An Approach to the Asymmetric α-Chlorination of Aldehydes and Terminal Epoxide Formation

(2009) Muriel Amatore et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The economies of synthesis

(2009) Timothy Newhouse et al.   CHEMICAL SOCIETY REVIEWS

Organocatalytic Asymmetric Synthesis Using Proline and Related Molecules. Part 2.

(2009) Hiyoshizo Kotsuki et al.   HETEROCYCLES

(S)-2-Pentyl (R)-3-Hydroxyhexanoate, a Banana Volatile and Its Olfactory Recognition by the Common Fruit Fly,Drosophila melanogaster

(2009) Jeffrey Mowat et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis at the molecular frontier

(2009) Paul A. Wender et al.   NATURE

A Switch of Facial Selectivities Using α-Heteroatom-Substituted Aldehydes in the Vinylogous Mukaiyama Aldol Reaction

(2009) Mariko Shinoyama et al.   ORGANIC LETTERS

Inverse Temperature Dependence in the Diastereoselective Addition of Grignard Reagents to a Tetrahydrofurfural

(2009) Jeffrey Mowat et al.   ORGANIC LETTERS

Development of a Concise and General Enantioselective Approach to 2,5-Disubstituted-3-hydroxytetrahydrofurans

(2009) Baldip Kang et al.   ORGANIC LETTERS

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Stereoselective Synthesis of α,α‐Chlorofluoro Carbonyl Compounds Leading to the Construction of Fluorinated Chiral Quaternary Carbon Centers

(2008) Kazutaka Shibatomi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Aminocatalysis-Gold Rush in Organic Chemistry

(2008) Paolo Melchiorre et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aldol Reactions between L-Erythrulose Derivatives and Chiral α-Amino and α-Fluoro Aldehydes: Competition between Felkin-Anh and Cornforth Transition States

(2008) Santiago Díaz-Oltra et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Stereoselective Synthesis of β-Lactams Utilizing α-Chloroimines as New and Powerful Chiral Inductors

(2008) Matthias D'hooghe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct Asymmetric Iodination of Aldehydes Using an Axially Chiral Bifunctional Amino Alcohol Catalyst

(2008) Taichi Kano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Dichlorination of Allylic Alcohol Derivatives to Access Key Stereochemical Arrays of the Chlorosulfolipids

(2008) Grant M. Shibuya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral NHC-Catalyzed Oxodiene Diels−Alder Reactions with α-Chloroaldehyde Bisulfite Salts

(2008) Ming He et al.   ORGANIC LETTERS