Bringing natural products into the fold – exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Functional models of Parkinson's disease: A valuable tool in the development of novel therapies

(2010) Peter Jenner   ANNALS OF NEUROLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1β by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells

(2009) Y Choi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol: A Promising Drug for Neurodegenerative Disorders?

(2009) Teresa Iuvone et al.   CNS Neuroscience & Therapeutics

Pathophysiology of Huntingtonʼs disease: from huntingtin functions to potential treatments

(2009) Emmanuel Roze et al.   CURRENT OPINION IN NEUROLOGY

Small molecule drug discovery for Huntington's Disease

(2009) Wolfgang Fecke et al.   DRUG DISCOVERY TODAY

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

(2009) Orly Weinreb et al.   Genes and Nutrition

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells

(2009) Kunio Kosaka et al.   JOURNAL OF BIOCHEMISTRY

Structure−Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral Infections

(2009) Jiangnan Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival

(2009) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Stem cell-based cell therapy in neurological diseases: A review

(2009) Seung U. Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

(2009) Edmund I. Graziani   NATURAL PRODUCT REPORTS

Transcriptional regulation of iNOS and COX-2 by a novel compound from Curcuma comosa in lipopolysaccharide-induced microglial activation

(2009) Anusorn Thampithak et al.   NEUROSCIENCE LETTERS

Nanolobatolide, a New C18Metabolite from the Formosan Soft CoralSinularia nanolobata

(2009) Yen-Ju Tseng et al.   ORGANIC LETTERS

6-Hydroxycleroda-3,13-dien-15,16-olide Protects Neuronal Cells from Lipopolysaccharide-Induced Neurotoxicity through the Inhibition of Microglia-Mediated Inflammation

(2009) Yu-Tzu Shih et al.   PLANTA MEDICA

Plants with neurobiological activity as potential targets for drug discovery

(2009) Nelson G.M. Gomes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mechanisms of Prion Protein Aggregation

(2009) Sarah Fontaine et al.   PROTEIN AND PEPTIDE LETTERS

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

(2009) Jose R Pineda et al.   Molecular Brain

Minocycline and neurodegenerative diseases

(2008) Hye-Sun Kim et al.   BEHAVIOURAL BRAIN RESEARCH

Huntington's disease: from pathology and genetics to potential therapies

(2008) Sara Imarisio et al.   BIOCHEMICAL JOURNAL

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

(2008) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Small molecule activators of the Trk receptors for neuroprotection

(2008) Nicholas JG Webster et al.   BMC NEUROSCIENCE

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis

(2008) John Hines et al.   CHEMISTRY & BIOLOGY

Resveratrol: A Natural Compound with Pharmacological Potential in Neurodegenerative Diseases

(2008) Héctor I. Rocha-González et al.   CNS Neuroscience & Therapeutics

Natural Products and their Derivatives as Cholinesterase Inhibitors in the Treatment of Neurodegenerative Disorders: An Update

(2008) Monica Loizzo et al.   CURRENT MEDICINAL CHEMISTRY

In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: Implications for Parkinson's Disease

(2008) J. Andrés Abin-Carriquiry et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

(2008) Judit Pallos et al.   HUMAN MOLECULAR GENETICS

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY

Alkaloids from the Leaves ofUncaria rhynchophyllaand Their Inhibitory Activity on NO Production in Lipopolysaccharide-Activated Microglia

(2008) Dan Yuan et al.   JOURNAL OF NATURAL PRODUCTS

Neuroprotective Limonoids of Root Bark ofDictamnus dasycarpus

(2008) Jeong Seon Yoon et al.   JOURNAL OF NATURAL PRODUCTS

Xanthones fromGentianella amarellassp.acutawith Acetylcholinesterase and Monoamine Oxidase Inhibitory Activities

(2008) A. Urbain et al.   JOURNAL OF NATURAL PRODUCTS

Antiparasitic, Antineuroinflammatory, and Cytotoxic Polyketides from the Marine SpongePlakortis angulospiculatusCollected in Brazil#

(2008) Miriam H. Kossuga et al.   JOURNAL OF NATURAL PRODUCTS

Research in motion: the enigma of Parkinson's disease pathology spread

(2008) Patrik Brundin et al.   NATURE REVIEWS NEUROSCIENCE

Role of Nitric Oxide Synthases in Parkinson’s Disease: A Review on the Antioxidant and Anti-inflammatory Activity of Polyphenols

(2008) Katia Aquilano et al.   NEUROCHEMICAL RESEARCH

FKBP Family Proteins: Immunophilins with Versatile Biological Functions

(2008) Cong Bao Kang et al.   NEUROSIGNALS

Disease-modifying drugs and Parkinson's disease

(2007) Hervé Allain et al.   PROGRESS IN NEUROBIOLOGY