Journal
NATURAL PRODUCT REPORTS
Volume 25, Issue 2, Pages 220-226Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b705665f
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DNA-binding small molecules are an important source of anticancer therapeutics that display a diverse array of mechanisms of action. Synthetic studies on the new DNA-alkylating natural product yatakemycin, detailed in this Highlight, have served to reassign its structure, assign the absolute stereochemistry, and provide access to yatakemycin and a series of structural analogues for biological evaluation. Studies on the DNA alkylation properties of (+)- and ent-(-)- yatakemycin and related analogues have demonstrated the enhanced DNA alkylation properties of this class of agents and provided insight into their interaction with DNA.
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