Article
Chemistry, Multidisciplinary
Thao T. Bui, Tam H. Nguyen, Hai L. Tran, Chau D. Tran, Duong T. Le, Dai N. Dao, Thao P. L. Nguyen, Luan T. Nguyen, Le-Thu T. Nguyen, Thiet Q. Nguyen, Son T. Cu, Mai H. Hoang, Tsutomu Yokozawa, Ha T. Nguyen
Summary: A conjugated diblock copolymer, P3HT-b-PDCTMA, was synthesized via Grignard metathesis and organo-catalyzed atom transfer radical polymerization, with a conversion of 73%. The copolymer showed an M-n of 17,500 g/mol, close to the theoretical value, and a polydispersity index (D) of 1.42. The copolymer bears reactive triazine chloride groups, allowing efficient nucleophilic aromatic substitution reactions with mercaptan or amine groups. The chemical structures and properties of the copolymer were characterized using FT-IR, H-1 NMR spectroscopy, and gel permeation chromatography, while UV-Vis spectroscopy was used to investigate its optical properties and conformation.
Article
Biochemistry & Molecular Biology
Van Hai Nguyen, Thanh Danh Nguyen, Jongwoo Song, Jongdeok An, Chan Im
Summary: Triblock copolymers consisting of three components, synthesized via Grignard metathesis polymerization, showed similar crystalline and melting temperatures. The power conversion efficiencies and photoluminescence properties of these copolymers were governed by the major components.
Article
Chemistry, Medicinal
Baohui Qi, Fei Wang, Huan He, Mengmeng Fan, Liping Hu, Li Xiong, Guowei Gong, Shengmin Shi, Xiaomeng Song
Summary: In this study, a series of novel quinoline derivates were designed, synthesized, and evaluated for their biological activity. Compound 8m showed potent c-Met and Ron inhibitory activity, as well as cytotoxic activity against various cancer cell lines. Isomer (S)-8m demonstrated high selectivity towards COLO 205 cells and low cytotoxicity against normal tissue cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yan Shi, Ying Wang, Wei Meng, Robert P. Brigance, Denis E. Ryono, Scott Bolton, Hao Zhang, Sean Chen, Rebecca Smirk, Shiwei Tao, Joseph A. Tino, Kristin N. Williams, Richard Sulsky, Laura Nielsen, Bruce Ellsworth, Michael K. Y. Wong, Jung-Hui Sun, Leslie W. Leith, Dawn Sun, Dauh-Rurng Wu, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Bang-Chi Chen, Aiying Wang, Helen G. Fuentes-Catanio, Lori Kunselman, Michael Cap, Jacob Zalaznick, Xiaohui Ma, Heng Liu, Joseph R. Taylor, Rachel Zebo, Beverly Jones, Stephen Kalinowski, Joann Swartz, Ada Staal, Kevin O'Malley, Lisa Kopcho, Jodi K. Muckelbauer, Stanley R. Krystek, Steven A. Spronk, Jovita Marcinkeviciene, Gerry Everlof, Xue-Qing Chen, Carrie Xu, Yi-Xin Li, Robert A. Langish, Yanou Yang, Qi Wang, Kamelia Behnia, Aberra Fura, Evan B. Janovitz, Nicola Pannacciulli, Steven Griffen, Bradley A. Zinker, John Krupinski, Mark Kirby, Jean Whaley, Robert Zahler, Joel C. Barrish, Jeffrey A. Robl, Peter T. W. Cheng
Summary: This article focuses on the investigation of a potential treatment for type 2 diabetes through the activation of glucokinase. By studying a series of compounds, a partial glucokinase activator was discovered and its pharmacokinetics and pharmacology were explored. The results show promising efficacy and safety, leading to the advancement of this activator into human clinical trials.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
W. Joychandra Singh, K. Jugeshwar Singh, K. P. Ramesh, K. Nomita Devi
Summary: Temperature and field dependent measurements were conducted to study the charge carrier mobility in Poly (3-octylthiophene) based metal/polymer/metal device structures with different concentrations. Negative field-dependent mobility (NFDM) was observed in highly doped devices, while positive field-dependent mobility (PFDM) was seen in moderately doped devices. The activation energy was found to vary based on doping level, indicating the importance of doping in thermally activated transport mechanism. Different equivalent circuits were observed in highly, moderately doped devices compared to low carrier concentration device, confirming the presence of energetic disorder in low carrier concentration devices.
Article
Chemistry, Physical
Ramesh Dalavai, Fazlur-Rahman Nawaz Khan
Summary: The facile synthesis of silicon-containing trimethylsilylated quinolines was achieved using TMSCN as a reagent and ZnI2 as a catalyst at room temperature in dichloromethane, resulting in excellent yields. Additionally, the silylated quinolines were successfully converted into quinolinyl acetonitriles in significant yields in the presence of dilute hydrochloric acid. The reaction of TMSCN with aldehyde functional groups formed protected silicon ethers as confirmed by HNMR, CNMR, and Mass spectral analysis.
Article
Biochemistry & Molecular Biology
Meena Patel, Hillary M. Peltier, Mark A. Matulenko, John R. Koenig, Marc J. C. Scanio, Rebecca J. Gum, Odile F. El-Kouhen, Meagan M. Fricano, Greta L. Lundgaard, Torben Neelands, Xu-Feng Zhang, Cenchen Zhan, Madhavi Pai, Nayereh Ghoreishi-Haack, Thomas Hudzik, Gary Gintant, Ruth Martin, Steve McGaraughty, Jun Xu, Daniel Bow, John C. Kalvass, Philip R. Kym, David A. DeGoey, Michael E. Kort
Summary: The voltage-gated sodium channel Na(v)1.7 is a promising target for pain treatment, and the discovery of 2-substituted quinolines and quinolones as potent small molecule Na(v)1.7 blockers has shown good efficacy and analgesic effects.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Suresha N. Deveshegowda, Prashant K. Metri, Rashmi Shivakumar, Ji-Rui Yang, Shobith Rangappa, Ananda Swamynayaka, Muthu K. Shanmugam, Omantheswara Nagaraja, Mahendra Madegowda, Priya Babu Shubha, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vijay Pandey, Kwang Seok Ahn, Peter E. Lobie, Basappa Basappa
Summary: Several thiouracil amide compounds were synthesized and screened for their anticancer properties against human breast cancer cells. Some compounds exhibited moderate to significant efficacy, inhibited the catalytic activity of PARP1, enhanced DNA repair and apoptosis, and interacted with PARP1. Therefore, thiouracil amides have the potential to be developed as new drug seeds for PARP inhibitors in oncology.
Article
Biochemistry & Molecular Biology
Yuting Zhou, Xingwei Xu, Fei Wang, Huan He, Baohui Qi
Summary: A novel series of 4,6,7-trisubstituted quinoline analogues containing thiazolidinones were designed and synthesized in this study. Compound 15i was identified as a potent multi-kinase inhibitor with significant antitumor activities against HT-29 cells. It induced apoptosis and cell cycle arrest in a dose- and time-dependent manner, while showing low toxicity to normal cells. Further structural modifications may lead to the development of more potent kinase inhibitors for cancer treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jianguang Zhou, Xingxian Gu, Shuping Yao, Jiong Ye, Peng Fu, Siqian Liu, Darija Dedic, Fabrice Gallou
Summary: A scalable and environmentally friendly route to produce the small molecule splicing modulator, branaplam, was developed. This approach eliminated the risk of dioxin formation associated with previous methods involving ortho-halo phenol derivatives. The synthesis involved a Friedel-Crafts reaction for the key intermediate and a Suzuki-Miyaura cross-coupling. The process was evaluated and a robust method for large-scale synthesis was successfully demonstrated.
HELVETICA CHIMICA ACTA
(2023)
Article
Materials Science, Composites
Venkatesan Raja, Zhao Hu, Guangming Chen
Summary: TE composites, especially PBTTT composites, show great potential for converting heat to electricity; PBTTT has advantages over inorganic materials in terms of low heat conductivity and high adjustability; The research on PBTTT TE composites with carbon nanotubes or graphene as constituents is advancing rapidly.
COMPOSITES COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Leandro Rodrigues Koenig, Aline Domingues Batista, Wesley Renzi, Henrique de Santana
Summary: This study aims to verify the optical properties of polymer systems on platinum for use in organic photovoltaic devices. The synthesis temperature and deposition method were found to significantly affect the stability of radical cation segments. Layered deposition favored the stabilization of these segments. Photoluminescence decay time confirmed that the relative amount of radical cation and dication segments in the polymer matrix affects their lifetime in different materials.
Article
Chemistry, Analytical
Mohammad Rostampour, Brian Bailey, Cody Autrey, Karla Ferrer, Brooke Vantoorenburg, Parth K. Patel, Percy Calvo-Marzal, Karin Y. Chumbimuni-Torres
Summary: The study investigated the effect of different solvents on the reproducibility of ISEs and proposed a method to integrate semiconducting/transducer polymer with single-walled carbon nanotubes into paper-based ISE substrates in a single step. PBISEs for potassium and sodium ions were developed with excellent sensor performance and reproducibility.
ANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Boriss Strumfs, Romans Uljanovs, Kirils Velikijs, Peteris Trapencieris, Ilze Strumfa
Summary: Aziridination reactions are a powerful tool in aziridine synthesis, with 3-arylated aziridine-2-carbonyl compounds playing a key role in medical and synthetic chemistry. Recent advances in the methodology of synthesizing these compounds via aziridination have been the focus of this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Mark Sabat, Douglas R. Dougan, Beverly Knight, J. David Lawson, Nicholas Scorah, Christopher R. Smith, Ewan R. Taylor, Phong Vu, Corey Wyrick, Haixia Wang, Deepika Balakrishna, Mark Hixon, Loui Madakamutil, Donavon McConn
Summary: This publication details the successful application of FBDD principles in the invention of a novel covalent Bruton's tyrosine kinase inhibitor, resulting in the development of Takeda Pharmaceuticals' clinical candidate TAK-020. The study describes the discovery and optimization process of the compound, as well as the synthesis and performance of TAK-020 in pharmacodynamic and efficacy models, along with a biophysical comparison with other clinical-level assets and the marketed drug Ibrutinib.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
A. Mavrikos, D. Papoulis, N. Todorova, I Papailias, C. Trapalis, D. Panagiotaras, D. A. Chalkias, E. Stathatos, E. Gianni, K. Somalakidi, D. Sygkridou, S. Komarneni
Summary: In this study, natural palygorskite clay was combined with TiO2 nanocrystals to create nanocomposites for photocatalytic air de-pollution. The nanocomposites showed superior performance in oxidation of air pollutants compared to traditional TiO2 catalysts, making them promising for indoor and outdoor air purification applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Junchi Li, Yifu Chen, Bin Zhang, Jia Li, Zaheen Uddin, Xinan Jiang, Xueyun Wang, Jiawang Hong, Yongbo Yuan, Elias Stathatos, Hanning Xiao, Anlian Pan, Yi Liu, Bin Yang
Summary: Positive bias can drive ion migration and promote self-doping, forming an advantageous p-i-n structure for better charge collection in photodetectors. In addition, tunneling of injected holes through interfaces also significantly contributes to the enhancement of EQE in positively-biased devices.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Energy & Fuels
Dimitris A. Chalkias, Argyroula Mourtzikou, Giannis Katsagounos, Aggeliki Karavioti, Alexandros N. Kalarakis, Elias Stathatos
Summary: This study focuses on the development of high-efficiency, stable, and reproducible large-sized all-printed perovskite modules using piezoelectric drop-on-demand inkjet-printing technology. The influence of perovskite precursor ink concentration on inkjet performance, substrate wettability, and the characteristics of the printed perovskite layers and photovoltaics were investigated. The results demonstrate that regulating the ink concentration effectively suppresses the coffee-ring effect and improves the quality and efficiency of the printed perovskite layers and photovoltaics.
Article
Chemistry, Physical
Constantinos Moularas, Christos Dimitriou, Yiannis Georgiou, Georgios Evangelakis, Nikos Boukos, Yiannis Deligiannakis
Summary: In this study, the mechanism of hot-electron transfer from plasmonic nanostructures to redox-active metals is quantitatively investigated. The presence of a 1 nm SiO2 shell on the nanoaggregates is found to play a crucial role in facilitating the hot-electron transfer via a decrease in activation energy, effectively suppressing the oxidative path and eliminating photothermal effects.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Pavlos Psathas, Areti Zindrou, Christina Papachristodoulou, Nikos Boukos, Yiannis Deligiannakis
Summary: ABO(3) perovskites are versatile photoactive materials that can be optimized for specific technologies by doping or heterojunction engineering. In this study, high crystallinity SrTiO3 nanoparticles with controlled La-doping and SrTiO3/CuO heterojunction formation were synthesized using Double-Nozzle Flame Spray Pyrolysis (DN-FSP) technology. The La:SrTiO3/CuO nanocatalysts showed improved photocatalytic activity for H2O/CH3OH mixtures compared to CuO-free La:SrTiO3, with the optimized La:SrTiO3/0.5%CuO catalyst achieving a photocatalytic CH4 production of 1.5 mmol g(-1) h(-1). The study demonstrates the potential of DN-FSP for scalable production of complex nanomaterials with controlled doping and heterojunction in a single-step synthesis.
Article
Pharmacology & Pharmacy
Nefeli Papadopoulou-Fermeli, Nefeli Lagopati, Natassa Pippa, Elias Sakellis, Nikos Boukos, Vassilis G. Gorgoulis, Maria Gazouli, Evangelia A. Pavlatou
Summary: The aim of this study is to synthesize titania-based composite materials with anticancer potential under visible-light irradiation. Specifically, silver-modified titanium dioxide nanoparticles are embedded in a stimuli-responsive microgel to form composite particles. The goal is to develop a drug-delivery system that uses optical fibers to photoactivate nanoparticles for targeting cancer cells. The resulting Ag-TiO2 nanoparticles and composite materials demonstrate high photocatalytic degradation efficiency and significant anticancer potential when exposed to visible light.
Article
Chemistry, Physical
Maria-Athina Apostolaki, Elias Sakellis, Polychronis Tsipas, Maria Giannouri, Spiros Gardelis, Nikos Boukos, Athanasios Dimoulas, Vlassis Likodimos
Summary: Heterostructured WO3/TiO2 photonic crystal films in the form of three-dimensional macroporous inverse opals were developed by single-step, three-phase co-assembly of colloidal templates with water soluble precursors. The properties of the inverse opals could be controlled by adjusting the W/Ti molar ratio and macropore diameter. This method provides a promising route for the development of heterostructured inverse opal networks with tailored electronic properties and improved solar light harvesting.
APPLIED SURFACE SCIENCE
(2023)
Article
Energy & Fuels
Zaheen Uddin, Junhui Ran, Elias Stathatos, Bin Yang
Summary: In this study, the thermal stability of perovskite solar cells was improved by adding thermoplastic polymer additives, which also enhanced the device stability and power conversion efficiency.
Review
Computer Science, Information Systems
Maria Bidikoudi, Elias Stathatos
Summary: This review presents the replacement of metal electrodes with carbon electrodes in high-performing perovskite solar modules (PSMs), aiming to overcome the obstacles of high cost and instability of metal electrodes. It provides an overview of the background and current status, highlights the potential of carbon electrodes, and discusses the challenges and future prospects.
Article
Engineering, Electrical & Electronic
Eleftherios Christopoulos, Mohamed M. Elsenety, Andreas Kaltzoglou, Constantinos C. Stoumpos, Mattia Gaboardi, Jasper R. Plaisier, Polychronis Tsipas, Elias Stathatos, Evangelos G. Vitoratos, Athanasios Dimoulas, Polycarpos Falaras
Summary: This study explores the use of the ionic liquid 1-hexyl-3-methylimidazolium iodide (HMImI) for the synthesis of a lead halide derivative, (HMIm)PbI3, which enhances the efficiency and stability of perovskite solar cells. The (HMIm)PbI3 compound forms 1D chains and acts as a semiconductor with a band gap of 2.85 eV. When deposited on top of the main perovskite absorber, it improves the radiative recombination and open circuit voltage by reducing trap state density, while preventing humidity penetration and ion migration.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ruben Canton-Vitoria, Nikolaos Heliopoulos, Nikos Boukos, Sozon Vasilakos, Dionysios Siamidis, Kostas Stamatakis, Nikos Tagmatarchis
Summary: This work presents a multi-step modification process to incorporate graphene oxide (GO) nanosheets into Kevlar fabric. Spectroscopic, thermal and microscopy imaging techniques were used to track the modification of Kevlar and the formation of the Kevlar-GO hybrid fabric. The level of functionalization of Kevlar can be controlled by nitration time, allowing for a content of GO up to 30%. The covalent modification of Kevlar does not compromise its mechanical properties and the Kevlar-GO hybrid fabric shows enhanced ultimate strength and significant antibacterial behavior.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Computer Science, Information Systems
Christos Falaras, Elias Stathatos
Summary: Advanced engineering strategies have been employed to improve the performance and stability of perovskite solar cells, focusing on interface engineering between the perovskite absorbing layer and the electron transport layer, as well as the perovskite and hole transport layer. Machine learning approaches have been used to validate experimental data and accurately predict solar cell parameters, confirming the significance and potential application of interface functionalization approaches.
Article
Chemistry, Physical
D. A. Chalkias, A. Mourtzikou, G. Katsagounos, A. N. Kalarakis, E. Stathatos
Summary: Inkjet-printing is an emerging manufacturing process for perovskite solar cells with low material wastes and high production throughput. This study demonstrates the feasibility of fabricating high-quality perovskite absorbent layers using an inkjet-printable perovskite precursor ink under ambient atmosphere. The fabricated solar cells show high efficiency and stability.
Article
Engineering, Electrical & Electronic
Alaa A. Zaky, Peter Sergeant, Elias Stathatos, Polycarpos Falaras, Mohamed N. Ibrahim
Summary: This work presents a high-efficiency and low-cost photovoltaic water-pumping system based on semitransparent dye-sensitized solar cells (DSSCs). The system utilizes the advantages of DSSCs, such as low cost and high efficiency, and is tested and validated through experiments and simulations. A control system for driving the motor efficiently using the inverter is also implemented.
Article
Engineering, Environmental
Ioannis Tournis, Dimitris Tsiourvas, Zili Sideratou, Lamprini G. Boutsika, Aggeliki Papavasiliou, Nikos K. Boukos, Andreas A. Sapalidis
Summary: Water is a precious natural resource, and its demand is expected to increase in the future. Scientists have developed innovative nanocomposite membranes to enhance the performance of membrane distillation for desalination. By introducing superhydrophobic nanoparticles on the membrane surface, these membranes exhibit improved fouling resistance and permeability, addressing critical issues in the membrane distillation process.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2022)
