Journal
NANOTECHNOLOGY
Volume 19, Issue 39, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/19/39/395102
Keywords
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Funding
- Biotechnology and Biological Sciences Research Council [BB/D007933/1]
- Department of Chemical Engineering, Cambridge
- Engineering and Physical Sciences Research Council [GR/S20789/01]
- BBSRC [BB/D007933/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D007933/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [GR/S20789/01] Funding Source: researchfish
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The use of magnetic fields in magnetic resonance imaging (MRI) for the tracking and delivery of chemotherapeutics bound to superparamagnetic nanoparticles offers a promising method for the non-invasive treatment of inoperable tumours. Here we demonstrate that superparamagnetic magnetite nanoparticles fabricated by an easily scalable method can be driven and tracked in real time at high velocities in vitro using MRI hardware. Force balance calculations are consistent with the magnetic properties of individual 10 nm diameter particles that move collectively as micron sized agglomerates with hydrodynamic diameter similar to that inferred from zero-magnetic-field dynamic light scattering measurements.
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