Article
Engineering, Biomedical
Xiuxiu Wang, Ru Cheng, Zhiyuan Zhong
Summary: High-efficacy targeted nanotherapeutics based on FDA approved polymers like PLGA, such as HA-sPLGA XNPs, show promise in achieving enhanced treatment of A549 lung tumor, with fast cellular uptake and significantly improved potency compared to other nanoparticles. These nanoparticles demonstrate prolonged elimination half-life and notable tumor accumulation, making them a unique and potentially translatable platform for chemotherapy of CD44-overexpressing tumors.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Wenqing Zang, Duo Gao, Miaorong Yu, Manmei Long, Zhuan Zhang, Tianhai Ji
Summary: Gemcitabine-loaded glycocholic acid-modified micelles (Gem-PPG) were prepared for enhanced oral chemotherapy. The micelles were transported across the intestinal epithelial monolayer via a specific pathway, with oral bioavailability of 81%. In a mouse model, oral Gem-PPG showed superior antitumor activity compared to the injected drug, with low toxicity indicated by hematological, biochemical, and histological assessments.
Article
Pharmacology & Pharmacy
Indrit Seko, Hayrettin Tonbul, Ece Tavukcuoglu, Adem Sahin, Sedenay Akbas, Hamdullah Yanik, Suleyman Can Ozturk, Gunes Esendagli, Mansoor Khan, Yilmaz Capan
Summary: This study successfully developed and characterized curcumin and docetaxel co-loaded poly lactide-co-glycolide nanoparticles to target glioma through improved brain penetration, showing potential for effective treatment by overcoming the blood brain barrier.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Giovanni Loureiro Raspantini, Marcela Tavares Luiz, Juliana Palma Abriata, Josimar de Oliveira Eloy, Miguel Menezes Vaidergorn, Flavio da Silva Emery, Juliana Maldonado Marchetti
Summary: This study developed polymeric nanoparticles based on PCL-block-TPGS containing docetaxel for prostate cancer therapy. The nanoparticles showed suitable characteristics for the proposed objectives and demonstrated high efficacy in cell death and internalization in vitro and in vivo studies. The docetaxel-loaded PCL-block-TPGS polymeric nanoparticle system is a potential treatment for prostate cancer.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
Keegan Braz Gomes, Bernadette D'Souza, Sharon Vijayanand, Ipshita Menon, Martin J. D'Souza
Summary: Effective vaccines delivered via painless methods would revolutionize vaccination. This study developed fast-dissolving microneedles to deliver antigen-loaded polymeric nanoparticles, achieving a dual-delivery platform for transdermal vaccination. The study demonstrated the feasibility of this approach and its potential for transdermal vaccine administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Magdalena Jurczyk, Janusz Kasperczyk, Dorota Wrzesniok, Artur Beberok, Katarzyna Jelonek
Summary: There is a growing interest in the use of chemosensitizers and cytostatics in combination to overcome cancer resistance to treatment. To overcome challenges such as poor bioavailability and chemical instability of drugs, attempts have been made to create nanoparticles for the delivery of docetaxel (Dtx) and resveratrol (Res). Recent reports suggest that nano-delivery systems for Dtx and Res exhibit better efficiency in cancer treatment than free drugs, and the simultaneous release of both drugs in cancer cells may help overcome limitations caused by multidrug resistance.
Article
Pharmacology & Pharmacy
Shruti Rawal, Shubham Khot, Vivek Bora, Bhoomika Patel, Mayur M. Patel
Summary: This study develops an orally administrable, folate-receptor-targeted Nanostructured lipid carriers (NLCs) of Docetaxel (DX) to overcome the bioavailability and toxicity issues of intravenous administration in lung cancer chemotherapy, showing promising antitumor efficacy and safety.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Susana Barbosa Ribeiro, Aurigena Antunes de Araujo, Maisie Mitchele Barbosa Oliveira, Alaine Maria dos Santos Silva, Arnobio Antonio da Silva-Junior, Gerlane Coelho Bernardo Guerra, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao, Raimundo Fernandes de Araujo Junior, Vinicius Barreto Garcia, Roseane Carvalho Vasconcelos, Caroline Addison Carvalho Xavier de Medeiros
Summary: Oral mucositis, characterized by severe ulcers in the oral region from chemotherapy, lacks effective therapy. Dexamethasone-loaded nanoparticles showed therapeutic effects in a hamster model, reducing inflammation, oxidative stress, and modulating gene expression.
Review
Pharmacology & Pharmacy
Dan Zhang, Lin Liu, Jian Wang, Hong Zhang, Zhuo Zhang, Gang Xing, Xuan Wang, Minghua Liu
Summary: Nanoparticles based on PLGA and PEG-PLGA have been extensively studied for drug delivery in cancer treatment. These nanoparticles can encapsulate and release various drugs, and their surface can be modified with ligands for active tumor targeting. This review provides an overview of the synthesis, application, and recent advances of PEG-PLGA nanoparticles in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yabing Xing, Xiao Li, Weiwei Cui, Meng Xue, Yanan Quan, Xinhong Guo
Summary: Structuring nanoparticles with glucose as a target is an effective strategy to enhance oral bioavailability and anti-tumor effects of drugs. In this study, a novel drug delivery system using glucose-modified zein nanoparticles loaded with docetaxel was prepared and characterized. The results showed that the glucose modification significantly enhanced cellular uptake and absorption of the nanoparticles, prolonged the drug's residence time in the body, and increased its oral bioavailability. The modified nanoparticles also reduced drug distribution in certain organs and increased tumor distribution and growth inhibition rate without causing systemic toxicity. These findings demonstrate the potential of glucose-modified zein nanoparticles as nanocarriers for enhancing the efficacy of oral drugs and their anti-tumor effects.
Article
Pharmacology & Pharmacy
Tingting Peng, Yao Huang, Xiaoqian Feng, Chune Zhu, Shi Yin, Xinyi Wang, Xuequn Bai, Xin Pan, Chuanbin Wu
Summary: The utilization of dissolving microneedles for locally delivering functionalized nanoparticles with combined chemotherapy and photothermal therapy has shown promising results in enhancing anti-tumor effects and reducing adverse reactions.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Polymer Science
Naz Dilawar, Tofeeq Ur-Rehman, Kifayat Ullah Shah, Humaira Fatima, Aiyeshah Alhodaib
Summary: The study investigates a transdermal delivery approach utilizing PLGA nanoparticles and PLO gel for more efficient drug release and permeation.
Article
Pharmacology & Pharmacy
Dan Yun, Dengyuan Liu, Jinlin Liu, Yanyi Feng, Hongyu Chen, Simiao Chen, Qingchun Xie
Summary: This study proposes a simplified surface modification strategy using cRGDyK peptide (RGD)-modified PLGA nanoparticles (NPs) loaded with paclitaxel. The results show that the modified NPs have excellent in vitro drug release properties and cellular uptake ability, leading to increased efficacy and reduced toxicity of the antitumor drug. In a mouse model experiment, the RGD-modified NPs exhibit a higher tumor weight suppression rate, demonstrating their promising potential in cancer therapy.
Article
Biophysics
Ibrahima Youm, Matthew B. West, Xiangping Huang, Wei Li, Richard D. Kopke
Summary: The effects of sucrose on the physical stability, cellular entry pathways, and functional efficacy of PLGA-NPs were investigated in this study. The results showed that the addition of 10% sucrose significantly improved the physical stability and cellular uptake of HEI-101-NPs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Gerard Esteruelas, Eliana B. Souto, Marta Espina, Maria Luisa Garcia, Marta Switalska, Joanna Wietrzyk, Anna Gliszczynska, Elena Sanchez-Lopez
Summary: Cancer is a leading cause of death worldwide, but there is still a need for an effective treatment with minimal adverse effects. Diclofenac, a non-steroidal anti-inflammatory drug, has shown promise as an antitumoral agent, but its prolonged use can lead to adverse effects. In this study, biodegradable polymeric nanoparticles were used to deliver diclofenac in a controlled manner, resulting in prolonged release and demonstrating antitumoral effects without cytotoxicity to non-tumoral cells.
Review
Pharmacology & Pharmacy
Qianqian Li, Zhaoqing Shi, Fan Zhang, Weiwei Zeng, Dunwan Zhu, Lin Mei
Summary: The immune system plays a critical role in cancer initiation and progression. Recent advancements in nanomaterials have expanded their applications in cancer immunotherapies, including drug carriers, inducers of immunogenic cell death, and immunomodulators. Nanomaterials can act as an integrated platform targeting multiple steps of the cancer-immunity cycle simultaneously, enhancing the effectiveness of anticancer immune response.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Li Yang, Yao Yang, Hongzhong Chen, Lin Mei, Xiaowei Zeng
Summary: Parenteral sustained release drug formulations have been widely used in clinical practice as preferable platforms for long-term exposure therapy. However, the requirement for hypodermic injection hinders their further applications due to issues such as needle-phobia, needle-stick injuries, and inappropriate needle reuse. Microneedles offer an alternative system that is minimally invasive and allows for self-administration.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Junqing Wang, Lin Mei, Wei Tao, Gang Liu
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Ting Chen, Weiwei Zeng, Changjun Tie, Mian Yu, Huisong Hao, Yang Deng, Qianqian Li, Hairong Zheng, Meiying Wu, Lin Mei
Summary: "Translation: The article introduces a new nanoplatform for sonodynamic therapy that uses ultrasound to induce the production of reactive oxygen species. The nanoplatform, Au/BP@MS, shows an increase in the efficiency of reactive oxygen species generation in tumor tissues, leading to significant inhibition of tumor growth. Furthermore, the nanoplatform exhibits responsiveness and degradability in the tumor microenvironment, enhancing its potential for clinical theranostics."
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Zhaoqing Shi, Jing Tang, Chuchu Lin, Ting Chen, Fan Zhang, Yuxing Huang, Ping Luan, Zhuo Xin, Qianqian Li, Lin Mei
Summary: This study developed an iron-mineralized black phosphorene nanosheet as a promising strategy for selective inhibition of tumor cells. The nanosheet showed enhanced cytotoxicity and excellent anti-tumor effects in combination with photothermal therapy.
Article
Chemistry, Multidisciplinary
Zimu Li, Yao Yang, Huaxuan Wei, Xiaoting Shan, Xuanzhi Wang, Meitong Ou, Qingyun Liu, Nansha Gao, Hongzhong Chen, Lin Mei, Xiaowei Zeng
Summary: A novel nanomedicine, MSN-Man-DOX@PDA-Gd-PEOz, was developed with excellent tumor targeting and penetration abilities, showing outstanding therapeutic effects in vivo and a promising prospect for clinical application.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Chao Pan, Zhuo Mao, Xue Yuan, Hanjie Zhang, Lin Mei, Xiaoyuan Ji
Summary: This review summarizes the recent progress and applications of heterojunction nanomedicine, discusses the catalytic mechanisms and properties in relation to biomedical applications, and presents some challenges and future directions in research.
Article
Engineering, Biomedical
Zimu Li, Zhidong Chen, Hongzhong Chen, Kebing Chen, Wei Tao, Xiao-kun Ouyang, Lin Mei, Xiaowei Zeng
Summary: Polyphenol-based hydrogels, as nature-derived bioactive materials, possess unique properties and have been widely used in biomedical fields. This review elaborates the evolution process of these hydrogels from crosslinking structures to biomedical applications and proposes efficient design considerations.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yan Zhang, Yuanchao Sun, Xia Dong, Qiang-Song Wang, Dunwan Zhu, Lin Mei, Husheng Yan, Feng Lv
Summary: In this study, a biomimetic platelet intelligent vehicle with navigation system was developed for controllable and visible drug delivery. The intelligent vehicle achieved efficient drug loading and controlled release by encapsulating photothermal-/pH-sensitive chemotherapeutic nanoparticles. It showed good tumor targeting and therapeutic efficacy in mouse models.
Article
Chemistry, Multidisciplinary
Meitong Ou, Chuchu Lin, Ying Wang, Yuting Lu, Wenyan Wang, Zimu Li, Weiwei Zeng, Xiaowei Zeng, Xiaoyuan Ji, Lin Mei
Summary: This study explores a new approach of utilizing active photosynthetic Chlorella functionalized with black phosphorus nanosheets for enhanced photodynamic therapy. The functionalized Chlorella improves tumor hypoxia and enhances immune cell activity and proliferation through photosynthesis. Additionally, the black phosphorus nanosheets improve the conversion efficiency of light and mediate chemodynamic therapy. The synergistic therapy shows high biocompatibility and potential biodegradability, suggesting promising clinical applications.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Chuchu Lin, Chenyi Huang, Zhaoqing Shi, Meitong Ou, Shengjie Sun, Mian Yu, Ting Chen, Yunfei Yi, Xiaoyuan Ji, Feng Lv, Meiying Wu, Lin Mei
Summary: Hydrogen sulfide (H2S) acts as a gasotransmitter molecule, activating intracellular signaling pathways and exerting concentration-dependent antitumor effects. By encapsulating calcium sulfide (CaS) and indocyanine green (ICG) into a biodegradable nanomodulator, researchers have achieved pH-responsive H2S release, enabling the suppression of catalase activity, abnormal Ca2?? retention, mitochondrial destruction, and oxidative stress amplification. This leads to blocked ATP synthesis and downregulated heat shock protein expression, effectively inhibiting tumor growth.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemical Research Methods
Yunfei Yi, Chan Feng, Mian Yu, Lin Mei, Meiying Wu, Wei Tao
Summary: Efficient gene delivery in an integrated drug delivery system is crucial for multimodal antitumor therapy. This study presents a protocol for constructing a peptide-based siRNA delivery system that achieves tumor vascular normalization and gene silencing in 4T1 cells. The system highlights four major steps and has the potential to silence gene expression and perform other treatments based on different peptide segments.
Review
Chemistry, Inorganic & Nuclear
Jun Li, Wang Liao, Dongqing Huang, Meitong Ou, Tongkai Chen, Xinlu Wang, Ruiyue Zhao, Lingyan Zhang, Lin Mei, Jun Liu, Ping Luan
Summary: Alzheimer's disease is a common central neurodegenerative disorder characterized by behavioral disturbance and progressive cognitive impairment. Accumulation of soluble oligomers and amyloid plaques outside nerve cells are crucial in its development. Advanced strategies for detecting and modulating amyloid beta (A beta) in diagnosis and treatment include the use of large-scale apparatus and novel devices, as well as therapeutic agents and nanomaterials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Guozheng Xing, Xuya Yu, Yan Zhang, Shupei Sheng, Limin Jin, Dunwan Zhu, Lin Mei, Xia Dong, Feng Lv
Summary: Pyroptosis-based immunotherapy using macrophage-based biohybrid microrobots shows promise in breast cancer treatment, as it can evade drug resistance, inhibit metastasis, and trigger an immune response. This novel strategy combines photothermal conversion, targeted drug delivery, and controlled drug release to achieve tumor-specific pyroptosis and enhance immunotherapy.
Article
Materials Science, Multidisciplinary
Hongzhong Chen, Tao Sun, Weiwei Zeng, Xiaowei Zeng, Lin Mei, Chen Jiang, Yanli Zhao
Summary: A hypoxia-activated prodrug has been developed in this study for combination therapy with photodynamic therapy (PDT), making the best use of the hypoxic tumor microenvironment. The combination of a hypoxia-responsive camptothecin (CPT)-based prodrug and a near-infrared (NIR) BODIPY photosensitizer allows for effectively combined PDT and chemotherapy, providing a promising approach for cancer treatment.
ACS MATERIALS LETTERS
(2022)
