Sulfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding

How entry inhibitors synergize to fight HIV

(2017) Gregory B. Melikyan   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted microbicides for preventing sexual HIV transmission

(2017) Catarina Coutinho et al.   JOURNAL OF CONTROLLED RELEASE

Polyanionic carbosilane dendrimers prevent hepatitis C virus infection in cell culture

(2017) Daniel Sepúlveda-Crespo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Carbosilane dendrons with fatty acids at the core as a new potential microbicide against HSV-2/HIV-1 co-infection

(2017) C. Guerrero-Beltrán et al.   Nanoscale

Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664

(2017) Kriti Acharya et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Isolation Methods of Peripheral Blood Mononuclear Cells in Spanish Biobanks: An Overview

(2017) Irene Consuegra et al.   Biopreservation and Biobanking

Lessons learned from human HIV vaccine trials

(2017) Justin Pollara et al.   Current Opinion in HIV and AIDS

Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes

(2017) Fernando Notario-Pérez et al.   Drug Design Development and Therapy

Nanomedicine in the development of anti-HIV microbicides

(2016) José das Neves et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted nanoparticles for colorectal cancer

(2016) Bruno A Cisterna et al.   Nanomedicine

Progress and Perspectives on HIV-1 microbicide development

(2016) Kabamba B. Alexandre et al.   VIROLOGY

Nanotech-derived topical microbicides for HIV prevention: The road to clinical development

(2015) Javier Sánchez-Rodríguez et al.   ANTIVIRAL RESEARCH

Specific Legislation on Biobanks in Spain

(2015) Isabel M García-Merino et al.   BIOPRESERVATION AND BIOBANKING

Anti-Human Immunodeficiency Virus Activity of Thiol-Ene Carbosilane Dendrimers and Their Potential Development as a Topical Microbicide

(2015) Javier Sánchez-Rodríguez et al.   Journal of Biomedical Nanotechnology

Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120

(2015) Rachna Aneja et al.   JOURNAL OF MEDICINAL CHEMISTRY

Macrocyclic Envelope Glycoprotein Antagonists that Irreversibly Inactivate HIV-1 before Host Cell Encounter

(2015) Adel A. Rashad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triple combination of carbosilane dendrimers, tenofovir and maraviroc as potential microbicide to prevent HIV-1 sexual transmission

(2015) Daniel Sepúlveda-Crespo et al.   Nanomedicine

Prevention vaginally of HIV-1 transmission in humanized BLT mice and mode of antiviral action of polyanionic carbosilane dendrimer G2-S16

(2015) Daniel Sepúlveda-Crespo et al.   Nanomedicine-Nanotechnology Biology and Medicine

The SPL7013 dendrimer destabilizes the HIV-1 gp120–CD4 complex

(2015) Bidisha Nandy et al.   Nanoscale

Improving preclinical models of HIV microbicide efficacy

(2015) Nadia R. Roan et al.   TRENDS IN MICROBIOLOGY

The key role of the scaffold on the efficiency of dendrimer nanodrugs

(2015) Anne-Marie Caminade et al.   Nature Communications

Specific Legislation on Biobanks in Spain

(2015) Isabel M García-Merino et al.   Biopreservation and Biobanking

Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study

(2015) Karen Smith-McCune et al.   PLoS One

Synthesis of new anionic carbosilane dendrimers via thiol–ene chemistry and their antiviral behaviour

(2014) Marta Galán et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Evaluation of the activity of new cationic carbosilane dendrimers on trophozoites and cysts of Acanthamoeba polyphaga

(2014) Irene Heredero-Bermejo et al.   PARASITOLOGY RESEARCH

5-(Perylen-3-yl)Ethynyl-arabino-Uridine (aUY11), an Arabino-Based Rigid Amphipathic Fusion Inhibitor, Targets Virion Envelope Lipids To Inhibit Fusion of Influenza Virus, Hepatitis C Virus, and Other Enveloped Viruses

(2013) C. C. Colpitts et al.   JOURNAL OF VIROLOGY

Synergistic activity profile of carbosilane dendrimer G2-STE16 in combination with other dendrimers and antiretrovirals as topical anti-HIV-1 microbicide

(2013) Daniel Sepúlveda-Crespo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Polyanionic Candidate Microbicides Accelerate the Formation of Semen-Derived Amyloid Fibrils to Enhance HIV-1 Infection

(2013) Suiyi Tan et al.   PLoS One

Women and HIV in Sub-Saharan Africa

(2013) Gita Ramjee et al.   AIDS Research and Therapy

Synthesis, structure and molecular modelling of anionic carbosilane dendrimers

(2012) Beatriz Rasines et al.   DALTON TRANSACTIONS

Carbosilane dendrimer nanotechnology outlines of the broad HIV blocker profile

(2012) L. Chonco et al.   JOURNAL OF CONTROLLED RELEASE

The determination and interpretation of the therapeutic index in drug development

(2012) Patrick Y. Muller et al.   NATURE REVIEWS DRUG DISCOVERY

Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety

(2012) Karissa Lozenski et al.   BMC Pharmacology & Toxicology

PD 404,182 Is a Virocidal Small Molecule That Disrupts Hepatitis C Virus and Human Immunodeficiency Virus

(2011) Ana Maria Chamoun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1

(2011) Sushama Telwatte et al.   ANTIVIRAL RESEARCH

Selective transmission of R5 HIV-1 variants: where is the gatekeeper?

(2011) Jean-Charles Grivel et al.   Journal of Translational Medicine

Pediatric HIV BioBank: A New Role of the Spanish HIV BioBank in Pediatric HIV Research

(2010) Isabel García-Merino et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Performance Evaluation of the New Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Test Version 2.0 for Quantification of Human Immunodeficiency Virus Type 1 RNA

(2010) S. Pas et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Evaluation of the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Test and Identification of Rare Polymorphisms Potentially Affecting Assay Performance

(2010) M. T. Pyne et al.   JOURNAL OF CLINICAL MICROBIOLOGY

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

(2010) Jasminka Sterjovski et al.   VIROLOGY

Palmitic Acid Is a Novel CD4 Fusion Inhibitor That Blocks HIV Entry and Infection

(2009) David Y.-W. Lee et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

A randomized, double-blind, placebo-controlled Phase II extended safety study of two Invisible Condom® formulations in Cameroonian women

(2009) Francois-Xavier Mbopi-Keou et al.   CONTRACEPTION

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection

(2009) Jesus F. Salazar-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Spanish HIV BioBank: a model of cooperative HIV research

(2009) Isabel Garcia-Merino et al.   Retrovirology

Tropism testing in the clinical management of HIV-1 infection

(2009) Nina H Lin et al.   Current Opinion in HIV and AIDS

HIV entry inhibitors and their potential in HIV therapy

(2008) Keduo Qian et al.   MEDICINAL RESEARCH REVIEWS

Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein

(2008) Eelco van Anken et al.   MOLECULAR BIOLOGY OF THE CELL

SAVVY Vaginal Gel (C31G) for Prevention of HIV Infection: A Randomized Controlled Trial in Nigeria

(2008) Paul J. Feldblum et al.   PLoS One