Reinforcement of polymeric nanoassemblies for ultra-high drug loadings, modulation of stiffness and release kinetics, and sustained therapeutic efficacy

Nanoparticle elasticity directs tumor uptake

(2018) Peng Guo et al.   Nature Communications

High drug-loading nanomedicines: progress, current status, and prospects

(2017) Shihong Shen et al.   International Journal of Nanomedicine

Synthesis of poly(1,2-glycerol carbonate)–paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer

(2017) Iriny Ekladious et al.   Chemical Science

Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma

(2016) Rong Liu et al.   BIOMATERIALS

pH-sensitive polymeric micelles formed by doxorubicin conjugated prodrugs for co-delivery of doxorubicin and paclitaxel

(2016) Yakun Ma et al.   CARBOHYDRATE POLYMERS

Synthetic Biomaterials from Metabolically Derived Synthons

(2016) Nicole G. Ricapito et al.   CHEMICAL REVIEWS

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

(2016) Nazila Kamaly et al.   CHEMICAL REVIEWS

Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy

(2016) Cong Luo et al.   NANO LETTERS

Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell–Nanoparticle Interaction

(2015) Lu Zhang et al.   ACS Nano

Clinical Translation of Nanomedicine

(2015) Yuanzeng Min et al.   CHEMICAL REVIEWS

Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs

(2015) Chin Siang KUE et al.   EXPERIMENTAL ANIMALS

Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake

(2014) Jiashu Sun et al.   ADVANCED MATERIALS

Molecularly Precise Dendrimer-Drug Conjugates with Tunable Drug Release for Cancer Therapy

(2014) Zhuxian Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Macromolecular therapeutics

(2014) Jiyuan Yang et al.   JOURNAL OF CONTROLLED RELEASE

Paclitaxel prodrug nanoparticles combining chemical conjugation and physical entrapment for enhanced antitumor efficacy

(2014) Xiuli Hu et al.   RSC Advances

Π–Π Stacking Increases the Stability and Loading Capacity of Thermosensitive Polymeric Micelles for Chemotherapeutic Drugs

(2013) Yang Shi et al.   BIOMACROMOLECULES

Synthesis of Atactic and Isotactic Poly(1,2-glycerol carbonate)s: Degradable Polymers for Biomedical and Pharmaceutical Applications

(2013) Heng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly(ethylene oxide)-block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional nanoparticles

(2013) Shiyi Zhang et al.   Chemical Science

Poly(ethylene oxide)-block-Polyphosphoester-graft-Paclitaxel Conjugates with Acid-Labile Linkages as a pH-Sensitive and Functional Nanoscopic Platform for Paclitaxel Delivery

(2013) Jiong Zou et al.   Advanced Healthcare Materials

Self-Assembly and Paclitaxel Loading Capacity of Cellulose-graft-poly(lactide) Nanomicelles

(2012) Yanzhu Guo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Uptake of hydrogel particles with different stiffness and its influence on HepG2 cell functions

(2012) Weijun Liu et al.   Soft Matter

Paclitaxel loaded carrier based biodegradable polymeric implants: Preparation and in vitro characterization

(2012) Jagadeesh G. Hiremath et al.   SAUDI PHARMACEUTICAL JOURNAL

Encapsulation of Alpha-1 antitrypsin in PLGA nanoparticles: In Vitro characterization as an effective aerosol formulation in pulmonary diseases

(2012) Nazanin Pirooznia et al.   JOURNAL OF NANOBIOTECHNOLOGY

Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration

(2011) Raymond Iezzi et al.   BIOMATERIALS

Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings

(2011) Elizabeth M. Enlow et al.   NANO LETTERS

Signature of hydrophobic hydration in a single polymer

(2011) I. T. S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the Collapse Dynamics of Poly(N-isopropylacrylamide) Brushes by AFM: Effects of Co-nonsolvency and Grafting Densities

(2011) Xiaofeng Sui et al.   Small

Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelles Containing Chemically Conjugated and Physically Entrapped Docetaxel: Synthesis, Characterization, and the Influence of the Drug on Micelle Morphology

(2010) Andrew S. Mikhail et al.   BIOMACROMOLECULES

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Nanoscopic mechanical anisotropy in hydrogel surfaces

(2010) Miriam V. Flores-Merino et al.   Soft Matter

Dendritic Polyglycerols for Biomedical Applications

(2009) Marcelo Calderón et al.   ADVANCED MATERIALS

Novel self-assembling PEG-p-(CL-co-TMC) polymeric micelles as safe and effective delivery system for Paclitaxel

(2009) Fabienne Danhier et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Effect of mechanical properties of hydrogel nanoparticles on macrophage cell uptake

(2009) Xavier Banquy et al.   Soft Matter

A Polymeric Molecular “Handle” for Multiple AFM-Based Single-Molecule Force Measurements

(2008) Francesco Valle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Paclitaxel-Initiated, Controlled Polymerization of Lactide for the Formulation of Polymeric Nanoparticulate Delivery Vehicles

(2008) Rong Tong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy assessment of sustained intraperitoneal paclitaxel therapy in a murine model of ovarian cancer using bioluminescent imaging

(2008) V Vassileva et al.   BRITISH JOURNAL OF CANCER

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY