Journal
NANOSCALE
Volume 10, Issue 2, Pages 690-704Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr06020c
Keywords
-
Categories
Funding
- 7-People Framework - Marie Curie Industry and Academia Partnerships & Pathways scheme (DNA-TRAP project [612338]
- Instituto de Ciencia de Materiales de Madrid (ICMM/CSIC)
- People Program (Marie Curie Actions) of the European Unionapos
- s Seventh Framework Program FP7 under REA grant [607142]
- European Commission Framework Program 7 (NanoMag project) [604448]
- Spanish Ministry of Economy and Competitiveness (Mago project) [MAT2014-52069-R]
- Ramon y Cajal subprogram [RYC-2014-15512]
- Marie Curie fellowship [705089-MIR-CHROM-C]
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/L001659/1] Funding Source: researchfish
Ask authors/readers for more resources
Multicore superparamagnetic nanoparticles have been proposed as ideal tools for some biomedical applications because of their high magnetic moment per particle, high specific surface area and long term colloidal stability. Through controlled aggregation and packing of magnetic cores it is possible to obtain not only single-core but also multicore and hollow spheres with internal voids. In this work, we compare toxicological properties of single and multicore nanoparticles. Both types of particles showed moderate in vitro toxicity (MTT assay) tested in Hep G2 (human hepatocellular carcinoma) and Caco-2 (human colorectal adenocarcinoma) cells. The influence of surface chemistry in their biological behavior was also studied after functionalization with O,O'-bis(2-aminoethyl) PEG (2000 Da). For the first time, these nanoparticles were evaluated in a Xenopus laevis model studying their whole organism toxicity and their impact upon iron metabolism. The degree of activation of the metabolic pathway depends on the size and surface charge of the nanoparticles which determine their uptake. The results also highlight the potential of Xenopus laevis model bridging the gap between in vitro cell-based assays and rodent models for toxicity assessment to develop effective nanoparticles for biomedical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available