4.8 Article

Stable and oxidant responsive zwitterionic nanoclusters

Journal

NANOSCALE
Volume 10, Issue 16, Pages 7382-7386

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr08951a

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Funding

  1. NIH [GM077173, EB022641]
  2. National Natural Science Foundation key project [31430031]
  3. National Distinguished Young Scholars grant [31225009]
  4. Strategic Priority Research Program of the Chinese Academy of Sciences [XDA09030301]
  5. China Scholarship Council

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Zwitterions are promising ligands for the fabrication of non-toxic and non-interacting biomaterials. Sulfonamide-based monothiol zwitterionic ligands on gold nanocluster (AuNC) surfaces provide nanomaterials with stable colloidal properties and intense red emission in biological environments. The fluorescence intensity of the nanocluster can be modulated by reactive oxygen species (e.g. OH), allowing for quantitative and selective sensing of antioxidants (e.g. ascorbic acid) in real time.

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