Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies

Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes

(2013) Weiwei Gao et al.   ADVANCED MATERIALS

Preclinical Evaluation of Genexol-PM, a Nanoparticle Formulation of Paclitaxel, as a Novel Radiosensitizer for the Treatment of Non-Small Cell Lung Cancer

(2013) Michael E. Werner et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform

(2013) Naama E. Toledano Furman et al.   NANO LETTERS

Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release

(2013) Santosh Aryal et al.   Nanomedicine

‘Marker-of-self’ functionalization of nanoscale particles through a top-down cellular membrane coating approach

(2013) Che-Ming J. Hu et al.   Nanoscale

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

(2013) Ronnie H. Fang et al.   Nanoscale

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

(2013) Zongdi Feng et al.   NATURE

Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

(2013) Lei Zhang et al.   NATURE BIOTECHNOLOGY

A biomimetic nanosponge that absorbs pore-forming toxins

(2013) Che-Ming J. Hu et al.   Nature Nanotechnology

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells

(2013) V. Ramakrishnaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle

(2013) S. Eliasof et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered SIRP  Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

(2013) K. Weiskopf et al.   SCIENCE

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation

(2012) Lei Zhang et al.   ACS Nano

Nanoparticle-based combination therapy toward overcoming drug resistance in cancer

(2012) Che-Ming Jack Hu et al.   BIOCHEMICAL PHARMACOLOGY

Synchronizing nonfouling and antimicrobial properties in a zwitterionic hydrogel

(2012) Luo Mi et al.   BIOMATERIALS

The effect of lightly crosslinked poly(carboxybetaine) hydrogel coating on the performance of sensors in whole blood

(2012) Wei Yang et al.   BIOMATERIALS

Zwitterionic polymer-modified silicon microring resonators for label-free biosensing in undiluted humanplasma

(2012) James T. Kirk et al.   BIOSENSORS & BIOELECTRONICS

Effects of surfactants on the properties of PLGA nanoparticles

(2012) Jyothi U. Menon et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Large-Scale Synthesis of Lipid–Polymer Hybrid Nanoparticles Using a Multi-Inlet Vortex Reactor

(2012) Ronnie H. Fang et al.   LANGMUIR

Superhydrophilic Zwitterionic Polymers Stabilize Liposomes

(2012) Zhiqiang Cao et al.   LANGMUIR

Simple and Robust Approach for Passivating and Functionalizing Surfaces for Use in Complex Media

(2012) Yuting Li et al.   LANGMUIR

Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices

(2012) YongTae Kim et al.   NANO LETTERS

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics

(2012) Jillian L. Perry et al.   NANO LETTERS

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

(2012) Alessandro Parodi et al.   Nature Nanotechnology

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

Erythrocyte-Inspired Delivery Systems

(2012) Che-Ming J. Hu et al.   Advanced Healthcare Materials

Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels

(2011) Minsoung Rhee et al.   ADVANCED MATERIALS

Exosome nanotechnology: An emerging paradigm shift in drug delivery

(2011) Samira Lakhal et al.   BIOESSAYS

The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation

(2011) Stanley J. Stachelek et al.   BIOMATERIALS

Multifunctional and degradable zwitterionic nanogels for targeted delivery, enhanced MR imaging, reduction-sensitive drug release, and renal clearance

(2011) Lei Zhang et al.   BIOMATERIALS

A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours

(2011) R Plummer et al.   BRITISH JOURNAL OF CANCER

Photocrosslinkable tissue adhesive based on dextran

(2011) Haibo Li et al.   CARBOHYDRATE POLYMERS

Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA

(2011) Tatsuaki Tagami et al.   JOURNAL OF CONTROLLED RELEASE

Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101

(2011) Sonke Svenson et al.   JOURNAL OF CONTROLLED RELEASE

Importance of Sialic Acid Residues Illuminated by Live Animal Imaging Using Phosphorylcholine Self-Assembled Monolayer-Coated Quantum Dots

(2011) Tatsuya Ohyanagi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymeric Nanoparticles with Precise Ratiometric Control over Drug Loading for Combination Therapy

(2011) Santosh Aryal et al.   MOLECULAR PHARMACEUTICS

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Polymer Architecture Mediates Switching of Complement Activation Pathways at the Nanosphere−Serum Interface: Implications for Stealth Nanoparticle Engineering

(2010) Islam Hamad et al.   ACS Nano

PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect

(2010) Sarbari Acharya et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks

(2010) Zhiqiang Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Evasion of the Accelerated Blood Clearance Phenomenon by Coating of Nanoparticles with Various Hydrophilic Polymers

(2010) Tsutomu Ishihara et al.   BIOMACROMOLECULES

Imaging and cell targeting characteristics of magnetic nanoparticles modified by a functionalizable zwitterionic polymer with adhesive 3,4-dihydroxyphenyl-l-alanine linkages

(2010) Lei Zhang et al.   BIOMATERIALS

PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid

(2010) Lucia Bondioli et al.   BIOMATERIALS

Effects of cleavable PEG-cholesterol derivatives on the accelerated blood clearance of PEGylated liposomes

(2010) Huan Xu et al.   BIOMATERIALS

Self inhibition of phagocytosis: The affinity of ‘marker of self’ CD47 for SIRPα dictates potency of inhibition but only at low expression levels

(2010) Richard K. Tsai et al.   BLOOD CELLS MOLECULES AND DISEASES

Phase I Study of NK012, a Novel SN-38-Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors

(2010) T. Hamaguchi et al.   CLINICAL CANCER RESEARCH

Therapeutic Nanoparticles to Combat Cancer Drug Resistance

(2010) Che-Ming Hu et al.   CURRENT DRUG METABOLISM

A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction

(2010) Juan W. Valle et al.   INVESTIGATIONAL NEW DRUGS

Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution

(2010) G. Tosi et al.   JOURNAL OF CONTROLLED RELEASE

Difference in Hydration between Carboxybetaine and Sulfobetaine

(2010) Qing Shao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Functionalizable and Ultrastable Zwitterionic Nanogels

(2010) Gang Cheng et al.   LANGMUIR

Half-Antibody Functionalized Lipid−Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen Presenting Pancreatic Cancer Cells

(2010) Che-Ming Jack Hu et al.   MOLECULAR PHARMACEUTICS

Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications

(2010) Jinjun Shi et al.   NANO LETTERS

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy

(2010) N. Kolishetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Assembled Core-Shell Vascular-Targeted Nanocapsules for Temporal Antivasculature and Anticancer Activities

(2010) Zhe Wang et al.   Small

Development of HPMA copolymer–anticancer conjugates: Clinical experience and lessons learnt

(2009) Ruth Duncan   ADVANCED DRUG DELIVERY REVIEWS

Polymer therapeutics: Clinical applications and challenges for development

(2009) María J. Vicent et al.   ADVANCED DRUG DELIVERY REVIEWS

Combination therapy: Opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines

(2009) Francesca Greco et al.   ADVANCED DRUG DELIVERY REVIEWS

Biodegradation, biodistribution and toxicity of chitosan

(2009) T. Kean et al.   ADVANCED DRUG DELIVERY REVIEWS

Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications

(2009) Shaoyi Jiang et al.   ADVANCED MATERIALS

Functionalizable and ultra stable nanoparticles coated with zwitterionic poly(carboxybetaine) in undiluted blood serum

(2009) Wei Yang et al.   BIOMATERIALS

Zwitterionic carboxybetaine polymer surfaces and their resistance to long-term biofilm formation

(2009) Gang Cheng et al.   BIOMATERIALS

Preclinical and clinical studies of anticancer agent-incorporating polymer micelles

(2009) Yasuhiro Matsumura et al.   CANCER SCIENCE

Preclinical Results of Camptothecin-Polymer Conjugate (IT-101) in Multiple Human Lymphoma Xenograft Models

(2009) T. Numbenjapon et al.   CLINICAL CANCER RESEARCH

Accelerated Blood Clearance Was Not Induced for a Gadolinium-Containing PEG-poly(L-lysine)-Based Polymeric Micelle in Mice

(2009) Huili Ma et al.   PHARMACEUTICAL RESEARCH

Nonfouling Behavior of Polycarboxybetaine-Grafted Surfaces: Structural and Environmental Effects

(2008) Zheng Zhang et al.   BIOMACROMOLECULES

Ultra low fouling zwitterionic polymers with a biomimetic adhesive group

(2008) Guozhu Li et al.   BIOMATERIALS

Biofunctionalized targeted nanoparticles for therapeutic applications

(2008) Andrew Z Wang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

(2008) P. Chytil et al.   JOURNAL OF CONTROLLED RELEASE

Coating of Vesicles with Hydrophilic Reactive Polymers

(2008) Čestmír Koňák et al.   LANGMUIR

Formation of Reversible Shell Cross-Linked Micelles from the Biodegradable Amphiphilic Diblock Copolymer Poly(l-cysteine)-block-Poly(l-lactide)

(2008) Jing Sun et al.   LANGMUIR

Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process

(2008) I. Hamad et al.   MOLECULAR IMMUNOLOGY

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY