Article
Chemistry, Analytical
Fuzhi Shen, Shining Xie, Hanrong Yan, Yuting Li, Shuqing Dong, Xing Zhang, Zhao Liu, Bei Miao, Fenglei Gao
Summary: This study developed a dual-mode strategy combining surface-enhanced Raman scattering (SERS) and fluorescence approaches for the detection of telomerase in complex biological environments. The dual-mode nanoprobe exhibited high selectivity and sensitivity to telomerase and could distinguish different types of tumor cells through in situ imaging.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Hyun Soo Kim, Hyun Jung Kim, Jaehun Lee, Taeha Lee, Jongsu Yun, Gyudo Lee, Yoochan Hong
Summary: The paper presents a method for liquid biopsy analysis using SERS technology, including the fabrication of a SERS substrate with silver nanosnowflakes for simultaneous detection of creatinine and cortisol in human sweat.
ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Yu Cui, Xiang Chen, Pengcheng Ma, Yukai Wang, Xiaoye Liang, Fenfen Zheng, Zheng Cai, Ping-xi Xiao, Lingling Li
Summary: In this study, a highly selective and sensitive colorimetric/SERS dual-mode sensing strategy was developed for the detection of TMAO. The strategy combines target-induced nanoprobe deactivation with a static headspace microextraction strategy. By tracking changes in colorimetric and SERS signals, the quantitative determination of TMAO was achieved. The proposed strategy exhibited a limit of detection of 1.57 μM in colorimetric mode and 5.33 μM in SERS mode. The dual-mode system was successfully applied for TMAO detection in real samples.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Siyu Luo, Lin Ma, Fei Tian, Yingqiu Gu, Jingjing Li, Peng Zhang, Guohai Yang, Haitao Li, Lu-Lu Qu
Summary: A dual-mode functional nanosensor based on fluorescence and surface-enhanced Raman scattering (SERS) was proposed for monitoring telomerase activity. The sensor uses Cy5-functional gold nanoparticles (Au NPs) as the dual functional nanoprobe. Changes in the distance between the signaling molecule Cy5 and Au NPs result in changes in the SERS and fluorescence signals, allowing for telomerase activity monitoring.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Qixin Liu, Ping Tang, Xinyue Xing, Wendai Cheng, Shengde Liu, Xiaoxu Lu, Liyun Zhong
Summary: The novel H2O2 dual-sensor synthesized by combining colorimetry and SERS via TMB-Fe3O4@AuNPs demonstrates improved detection sensitivity and is applicable for detecting H2O2 in plasma and milk.
Article
Biophysics
Dandan Zhang, Jing Ma, Xinxin Zheng, Zilong Zhang, Xiaojuan Lian, Xue Zhao, Xinfeng Zhao
Summary: A novel SERS probe was designed and fabricated for specific capture and fast detection of small molecule ligands binding to target protein. The probe was successfully synthesized by coating SiO2@Ag nanoclusters with 6-chlorohexanoic acid for immobilization of serotonin transporter (5-HTT). Through characterization and verification using TEM, XPS, and elemental mapping, the probe was applied to analyze Gardenia jasminoides extract and successfully identified crocin I as a compound binding to 5-HTT. The study demonstrates the potential of combining SERS with affinity-guided molecular capture in drug screening.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Xiumei Zhuang, Yongjun Hu, Junjie Wang, Jieyu Hu, Qi Wang, Xingxing Yu
Summary: A novel colorimetric and SERS dual-readout assay using 4-MPBA as the Raman-active and recognition molecule was developed for the determination of TYR activity, showing high selectivity and rapid response. The introduction of magnetic beads improved the anti-interference ability of the dual-mode sensor in complex media.
ANALYTICA CHIMICA ACTA
(2021)
Article
Nanoscience & Nanotechnology
Jie Yao, Zhao Jin, Yuan Zhao
Summary: Dual-mode nanotags with noninterference sensing signals were fabricated to enhance the detection accuracy and sensitivity for tetrodotoxin (TTX) monitoring. The use of Ag@Cu2O nanoparticles exhibited strong SERS performance and improved EM fields for SERS enhancement. The designed electrochemical and SERS signal-programed dual-mode aptasensor achieved accurate TTX detection with low limits of detection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Qiangting Zheng, Qinyi Li, Sen Hu, Xiaoyu Guo, Haifeng Yang
Summary: An abnormal intake of Cu2+ can lead to cellular homeostasis disruption, oxidative damage, cardiovascular disorders, severe neurodegenerative disorders, and cancer. A rapid SERS assay for picomolar copper ions is developed based on the click reaction of Cu+-catalyzed alkyne azide cycloaddition. This method shows high sensitivity and selectivity and can be used for water quality assessment in onshore and offshore water treatment systems.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Spectroscopy
Zhiyi Song, Xinyi Wang, Peifang Chen, Zhouping Wang, Xiaoyuan Ma
Summary: In this study, a SERS/fluorescence dual-mode nanosensor using gold nanoflowers as substrate was designed for the detection of Aflatoxin B1 (AFB1). By modifying the surface of gold nanoflowers and attaching AFB1 aptamer and complementary sequence functionalized with Cy5, the quantitative detection of AFB1 was successfully achieved with high sensitivity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biophysics
Hao Wang, Bianbian Zhao, Yufei Ye, Xiaoyu Qi, Yuting Zhang, Xiaole Xia, Xiaoli Wang, Nandi Zhou
Summary: In this study, a fluorescence and surface-enhanced Raman scattering dual-mode aptasensor was developed for sensitive and rapid detection of Ochratoxin A (OTA). The aptasensor demonstrated low detection limits in both FL and SERS modes, as well as high specificity and good interferent resistance. It showed great potential for OTA detection in coffee and wine samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Chengcheng Gu, Lipeng Bai, Ting Hou, Lei Zhang, Panpan Gai, Feng Li
Summary: A dual-mode biosensing platform based on FeSx/SiO2 nanoparticles was developed for the accurate detection of intracellular/extracellular H2O2. The platform exhibited high accuracy, sensitivity and reliability, making it a promising tool for H2O2 detection.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Jingxing Guo, Yueqin Liu, Longjiang Zhang, Jing Pan, Yingfei Wang, Yiqing Wang, Huiming Cai, Huangxian Ju, Guangming Lu
Summary: This work presents a new ascorbic acid-responsive chemo-chromic SERS sensing chip for synergistic dual-modal on-site analysis. The chip shows rapid colorimetric response and linear SERS response, making it suitable for food and biomedical analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Rui Gao, Dan Li, Qinmei Zhang, Siqing Zheng, Xingang Ren, Wei Deng
Summary: A new tri-mode method utilizing gold nanoparticles and quantum dots for on-site detection and discrimination of trinitrotoluene (TNT) was proposed in this study. The visualization of TNT detection was achieved through colorimetric, fluorescent, and Raman scattering responses, with good linearity and a low detection limit.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yakun Gao, Yingkuan Han, Chao Wang, Le Qiang, Jianwei Gao, Yanhao Wang, Hong Liu, Lin Han, Yu Zhang
Summary: This article introduces a triple-mode biosensor based on AuNPs, which can rapidly and selectively detect viral RNA, achieving femtomole level detection limits in absorbance, fluorescence, and SERS modes. The sensor effectively minimizes false negative/positive readings of SARS-CoV-2.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.