4.8 Article

Optimizing the selective recognition of protein isoforms through tuning of nanoparticle hydrophobicity

Journal

NANOSCALE
Volume 6, Issue 12, Pages 6492-6495

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr01085j

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Funding

  1. NIH [GM077173, EB014277]
  2. Fundamental Research Funds for the Central Universities
  3. China Scholarship Council

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We demonstrate that ligand hydrophobicity can be used to increase affinity and selectivity of binding between monolayer-protected cationic gold nanoparticles and beta-lactoglobulin protein isoforms containing two amino acid mutations.

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