Journal
NANOSCALE
Volume 5, Issue 23, Pages 11582-11586Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr03665k
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Funding
- MOST [2011CB933600]
- NSFC [21073181, 21203177]
- 100 talent Program of CAS
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We describe a concise and effective strategy towards precisely mapping Na+-K+ ATPases on the cytoplasmic side of cell membranes by direct stochastic optical reconstruction microscopy (dSTORM). We found that most Na+-K+ ATPases are localized in different sizes of clusters on human red blood cell (hRBC) membranes, revealed by Ripley's K-function analysis. Further evidence that cholesterol depletion causes the dispersion of Na+-K+ ATPase clusters indicates that such clusters could be localized in cholesterol-enriched domains. Our results suggest that Na+-K+ ATPases might aggregate within the lipid rafts to fulfill their functions.
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