Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 215, Issue -, Pages 93-98Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2015.03.047
Keywords
Cyanide; Aqueous; Turn on; Fluorescent probe; Bioimaging
Funding
- National Natural Science Foundation of China [21102086, 21472118]
- Shanxi Province Science Foundation for Youths [2012021009-4, 201301101-11]
- Shanxi Province Foundation for Returnee [2012-007]
- Taiyuan Technology star special [12024703]
- Program for the Top Young and Middle-aged Innovative Talents of Higher Learning Institutions of Shanxi [2013802]
- Talents Support Program of Shanxi Province [2014401]
- Shanxi Province Outstanding Youth Fund [2014021002]
Ask authors/readers for more resources
A turn on fluorescent probe for cyanide has been rationally constructed based on an intramolecular charge transfer (ICT) mechanism. Upon treatment with cyanide, probe 1 exhibited a strong fluorescence emission based on blocking ICT. The emission showed good linearity with the cyanide concentration in the range of 0-1.8 mu M, and the detection limit measured to be as low as 0.05 mu M. The NMR experiments confirmed that the ratiometric response of probe 1 to cyanide is due to the electrophilic addition reaction, which results in the inhibition of the ICT process in the probe. Furthermore, the qualitative determination of exogenous cyanide in HepG2 cells demonstrated that the probe can be employed to detect exogenous cyanide in real biological samples. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available