Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 213, Issue -, Pages 343-350Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2015.02.105
Keywords
Fluorescent probe; Hg2+; BODIPY; HeLa cells; Zebrafish; Nude mouse
Funding
- National Natural Science Foundation of China [21174061]
- National Basic Research Program of China [2014CB846004]
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]
- Jiangsu Province Science Technology Innovation and Achievements Transformation Special Fund [BY2012149]
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In this paper, we developed a new selectively fluorescent probe for Hg2+ based on BODIPY. The probe exhibited strong affinity for Hg2+ over other metal ions. Treatment with Hg2+ would turn on the fluorescence of the probe, and strong green fluorescence could be observed. The binding constant (K-a) of the probe with Hg2+ was calculated to be 9.43 x 10(4) M-1 from a Benesi-Hildebrand plot and the detection limit was evaluated to be as low as 1.73 nM (LOD = 3 sigma/slope, sigma is standard deviation). Biological applications were investigated employing living HeLa cells, zebrafish and nude mouse. (C) 2015 Elsevier B.V. All rights reserved.
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