pH-sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances

Targeted Delivery of Dendritic Polyglycerol–Doxorubicin Conjugates by scFv-SNAP Fusion Protein Suppresses EGFR+ Cancer Cell Growth

(2013) Ahmad Fawzi Hussain et al.   BIOMACROMOLECULES

Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier To Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells

(2013) Xiaoyan Wang et al.   BIOMACROMOLECULES

Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions

(2013) Liangliang Wu et al.   BIOMATERIALS

Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery

(2013) Ru Cheng et al.   BIOMATERIALS

Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells

(2013) Masao Kamimura et al.   Biomaterials Science

Polymer Micelle with pH-Triggered Hydrophobic–Hydrophilic Transition and De-Cross-Linking Process in the Core and Its Application for Targeted Anticancer Drug Delivery

(2012) Jianquan Fan et al.   BIOMACROMOLECULES

Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-deoxycholic acid conjugate-modified N-deoxycholic acid-O, N-hydroxyethylation chitosan micelles

(2012) Meirong Huo et al.   BIOMATERIALS

The tumor accumulation and therapeutic efficacy of doxorubicin carried in calcium phosphate-reinforced polymer nanoparticles

(2012) Kyung Hyun Min et al.   BIOMATERIALS

pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride

(2012) Yinfeng Du et al.   BIOMATERIALS

The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

(2012) Wenchuan She et al.   BIOMATERIALS

pH-triggered blooming of ‘nano-flowers’ for tumor intracellular drug delivery

(2012) Zhefan Yuan et al.   CHEMICAL COMMUNICATIONS

Comparative studies of polyethylenimine-doxorubicin conjugates with pH-sensitive and pH-insensitive linkers

(2012) Da-Wen Dong et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma

(2012) Yali Wu et al.   JOURNAL OF CONTROLLED RELEASE

Targeting and anti-tumor effect of folic acid-labeled polymer–Doxorubicin conjugates with pH-sensitive hydrazone linker

(2012) Xiuli Hu et al.   JOURNAL OF MATERIALS CHEMISTRY

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

(2012) Erlei Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intracellular drug release nanosystems

(2012) Fenghua Meng et al.   Materials Today

pH Triggered Doxorubicin Delivery of PEGylated Glycolipid Conjugate Micelles for Tumor Targeting Therapy

(2012) Fu-Qiang Hu et al.   MOLECULAR PHARMACEUTICS

Polymeric micelle stability

(2012) Shawn C. Owen et al.   Nano Today

Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

(2012) Chao Deng et al.   Nano Today

Precise control of intracellular drug release and anti-tumor activity of biodegradable micellar drugs via reduction-sensitive shell-shedding

(2012) Wei Wang et al.   Soft Matter

Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin

(2011) Xiao-Bing Xiong et al.   ACS Nano

Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells

(2011) Feng Wang et al.   ACS Nano

Biocompatible Poly(2-hydroxyethyl methacrylate)-b-poly(L-histidine) Hybrid Materials for pH-Sensitive Intracellular Anticancer Drug Delivery

(2011) Renjith P. Johnson et al.   ADVANCED FUNCTIONAL MATERIALS

Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release

(2011) Jian Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Endosomal pH-Activatable Poly(ethylene oxide)-graft-Doxorubicin Prodrugs: Synthesis, Drug Release, and Biodistribution in Tumor-Bearing Mice

(2011) Lei Zhou et al.   BIOMACROMOLECULES

Ketal Cross-Linked Poly(ethylene glycol)-Poly(amino acid)s Copolymer Micelles for Efficient Intracellular Delivery of Doxorubicin

(2011) Sang Jin Lee et al.   BIOMACROMOLECULES

Oxime Linkage: A Robust Tool for the Design of pH-Sensitive Polymeric Drug Carriers

(2011) Yue Jin et al.   BIOMACROMOLECULES

Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release

(2011) Fuxing Zhan et al.   BIOMACROMOLECULES

Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

(2011) Jin-Zhi Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anticancer Drug Delivery and Ultrasensitive MR Imaging

(2010) Xiaoqiang Yang et al.   ACS Nano

A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery

(2010) Jin-Zhi Du et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy

(2010) Xiang Lan Wu et al.   BIOCONJUGATE CHEMISTRY

Biodegradable Block Copolymer-Doxorubicin Conjugates via Different Linkages: Preparation, Characterization, and In Vitro Evaluation

(2010) Xiuli Hu et al.   BIOMACROMOLECULES

Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin

(2010) Marina Talelli et al.   BIOMATERIALS

A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction

(2010) Juan W. Valle et al.   INVESTIGATIONAL NEW DRUGS

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Shedding the hydrophilic mantle of polymersomes

(2010) René P. Brinkhuis et al.   Polymer Chemistry

Biological Evaluation of Polymeric Micelles with Covalently Bound Doxorubicin

(2009) David Vetvicka et al.   BIOCONJUGATE CHEMISTRY

Preparation of Multifunctional Drug Carrier for Tumor-Specific Uptake and Enhanced Intracellular Delivery through the Conjugation of Weak Acid Labile Linker

(2009) Caixia Ding et al.   BIOCONJUGATE CHEMISTRY

pH-Responsive Biodegradable Micelles Based on Acid-Labile Polycarbonate Hydrophobe: Synthesis and Triggered Drug Release

(2009) Wei Chen et al.   BIOMACROMOLECULES

Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin

(2009) Huanli Sun et al.   BIOMATERIALS

Biodegradable amphiphilic polymer–drug conjugate micelles

(2009) Xiuli Hu et al.   Expert Opinion on Drug Delivery

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

(2009) Seymour   INTERNATIONAL JOURNAL OF ONCOLOGY

A smart flower-like polymeric micelle for pH-triggered anticancer drug release

(2009) Kyung Taek Oh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model

(2009) R. Graeser et al.   INVESTIGATIONAL NEW DRUGS

pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: A comparative study with micelles

(2009) Wei Chen et al.   JOURNAL OF CONTROLLED RELEASE

In Vivo Evaluation of Doxorubicin-Loaded Polymeric Micelles Targeting Folate Receptors and Early Endosomal pH in Drug-Resistant Ovarian Cancer

(2009) Dongin Kim et al.   MOLECULAR PHARMACEUTICS

Extracellularly Activated Nanocarriers: A New Paradigm of Tumor Targeted Drug Delivery

(2009) Emily Gullotti et al.   MOLECULAR PHARMACEUTICS

Stability issues of polymeric micelles

(2008) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Recent progress in tumor pH targeting nanotechnology

(2008) Eun Seong Lee et al.   JOURNAL OF CONTROLLED RELEASE

Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance

(2008) Eun Seong Lee et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY