Article
Multidisciplinary Sciences
Qihong Yu, Jin-Xin Liu, Xichuan Zheng, Xueke Yan, Peng Zhao, Chuanzheng Yin, Wei Li, Zifang Song
Summary: This study reveals the significant role of Sox9 in mediating autophagy-dependent vSMC phenotypic modulation and the development of TA. Inhibition of Sox9 expression can attenuate neointimal formation, providing a potential therapeutic approach for vascular pathologies.
Review
Nanoscience & Nanotechnology
Zhiwei Jia, Shunxin Zhang, Wei Li
Summary: Degenerative bone disorders such as IVDD, OA, and OP present significant challenges for aging populations with no effective treatments available. The use of stem cell-derived EVs as a novel therapeutic approach holds promise in addressing these disorders. However, a comprehensive assessment of EV-based therapies in degenerative bone disorders is currently lacking. This review aims to fill this gap by summarizing the current state of the field and discussing the potential of EV-based treatments for IVDD, OA, and OP.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Cell & Tissue Engineering
Hamza Atcha, Yu Suk Choi, Ovijit Chaudhuri, Adam J. Engler
Summary: Advances in biomaterial science have improved our understanding of how material cues impact stem cell function. These approaches provide more realistic models of the cell niche and have led to novel mechanobiological studies in model organisms. This review discusses the importance of material cues within the cell niche, highlights key mechanotransduction pathways, and presents recent evidence of material cues regulating tissue function in vivo.
Article
Chemistry, Multidisciplinary
Yongmei Zhao, Kaikai Wang, Yuanlin Zheng, Xiaobao Zeng, Yi Chieh Lim, Tianqing Liu
Summary: A specific multi-target drug delivery nanoparticle system targeting breast cancer stem cells has been developed with a therapeutic efficacy. The system combines curcumin and salinomycin, inducing G(1) cell cycle arrest and limiting epithelial-mesenchymal transition effectively.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Analytical
Craig Watson, Chao Liu, Ali Ansari, Helen C. Miranda, Rodrigo A. Somoza, Samuel E. Senyo
Summary: This article presents a microfluidic chip that allows the culture of cells in adjacent chambers and enables selective exchange of paracrine signals. The chip offers both high throughput and control over the onset and duration of cell-cell communication.
Article
Pharmacology & Pharmacy
Sung Hyun Noh, Han-Saem Jo, Somang Choi, Hee Gyeong Song, Hak-Jun Kim, Keung Nyun Kim, Sung Eun Kim, Kyeongsoon Park
Summary: The study prepared LF/TA-MSNs and evaluated their impact on ADSCs, finding that LF/TA-MSNs enhanced the osteo-differentiation ability of ADSCs. LF/TA-MSNs effectively promoted ALP levels, calcium accumulation, and expression of osteo-differentiation-specific genes in ADSCs.
Article
Multidisciplinary Sciences
T. Deckers, J-M Aerts, V Bloemen
Summary: In this study, a novel cell detachment feature was developed using lens-free imaging technology, allowing quantitative monitoring of the detachment response and determination of the optimal time for enzyme inhibition.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Natthakan Thongon, Feiyang Ma, Andrea Santoni, Matteo Marchesini, Elena Fiorini, Ashley Rose, Vera Adema, Irene Ganan-Gomez, Emma M. Groarke, Fernanda Gutierrez-Rodrigues, Shuaitong Chen, Pamela Lockyer, Sarah Schneider, Carlos Bueso-Ramos, Guillermo Montalban-Bravo, Caleb A. Class, Kelly A. Soltysiak, Matteo Pellegrini, Ergun Sahin, Alison A. Bertuch, Courtney D. DiNardo, Guillermo Garcia-Manero, Neal S. Young, Karen Dwyer, Simona Colla
Summary: The study reveals that telomere attrition leads hematopoietic stem cells towards differentiation into megakaryocytic lineage through upregulated innate immune signaling response, ultimately compromising their self-renewal capabilities and leading to depletion. Targeting the IFI16 signaling axis could potentially prevent functional decline of hematopoietic stem cells under conditions affecting telomere maintenance.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Silvio Almeida Junior, Poliana Marques Pereira, Vanessa de Souza Totoli, Edna Sousa Neves, Mayara Monochio, Alef Winter Oliveira Alvarenga, Juliana Issa Hori, Wilson Rodrigues Braz, Lucas Alonso Rocha, Eduardo Jose Nassar, Marcela Aldrovani, Ricardo Andrade Furtado
Summary: The study found that incorporating indomethacin into mesoporous silica nanoparticles can effectively alleviate pain and inflammation, while reducing the gastric and hepatic damage caused by indomethacin.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Erin W. Meermeier, Leif Bergsagel
Summary: Multiple myeloma is a malignant disease characterized by bone marrow tumors and bone lesions. Autologous stem cell transplantation followed by lenalidomide maintenance therapy is the standard treatment for multiple myeloma. However, relapse is common. In this study, the addition of a checkpoint inhibitor to lenalidomide maintenance therapy was investigated and found to enhance the immune response and improve the efficacy of the treatment in a mouse model of multiple myeloma.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Marika Sjoqvist, Daniel Antfolk, Freddy Suarez-Rodriguez, Cecilia Sahlgren
Summary: Intermediate filaments have emerged as important regulators of cellular signaling events, beyond providing structural support, by regulating cell differentiation and influencing cell fate decisions in conjunction with stem cell signaling pathways. Lack of IFs causes perturbed stem cell differentiation, and deregulation in these signaling pathways can result in various diseases. Studying the interaction and regulation of IFs with cell signaling helps expand our understanding of IF-linked diseases.
Review
Biochemistry & Molecular Biology
Jiang Qian, Xue Gao, Ya-Di Wang, Xue-Ling Li, Jun Hu, Jun-Hong Lu
Summary: Stem cells have shown great potential for tissue regeneration and repair due to their unlimited self-renewal and differentiation capabilities. However, the complex interactions between niches and stem cells, along with the limitations of current systems or methods, pose challenges to the multi-faceted applications of stem cells. Emerging evidence suggests that synchrotron infrared microspectroscopy may offer a promising non-invasive technology for stem cell research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Renwang Sheng, Jia Liu, Wei Zhang, Yifan Luo, Zhixuan Chen, Jiayu Chi, Qingyun Mo, Mingyue Wang, Yuzhi Sun, Chuanquan Liu, Yanan Zhang, Yue Zhu, Baian Kuang, Chunguang Yan, Haoyang Liu, Ludvig J. Backman, Jialin Chen
Summary: This study found that soft materials are more likely to guide stem cell differentiation into tendon lineage, providing comprehensive evidence for optimized bioactive scaffold design in tendon tissue engineering.
Article
Biochemistry & Molecular Biology
Renjun Tu, Bo Duan, Xiaoqing Song, Shiyuan Chen, Allison Scott, Kate Hall, Jillian Blanck, Dustin DeGraffenreid, Hua Li, Anoja Perera, Jeff Haug, Ting Xie
Summary: In the Drosophila ovary, inner germarial sheath (IGS) cells form multiple niche compartments that interact with different stages of germline stem cell (GSC) progeny, regulating stem cell self-renewal and stepwise differentiation.
Article
Chemistry, Multidisciplinary
Suqing Yin, Po Gao, Luodan Yu, Ling Zhu, Weifeng Yu, Yu Chen, Liqun Yang
Summary: In this study, a core/shell-structured two-dimensional silicene nanosheets coated with mesoporous silica layer were utilized as a drug delivery system for localized anesthesia. The system exhibited on-demand and long-lasting regional anesthesia effect, surpassing the analgesic effect of free drugs. It also demonstrated the ability to improve pain threshold and reduce neuronal activation in relevant pathways.
Article
Biochemistry & Molecular Biology
Yanan Huang, Alfonso E. Garcia-Bennett
Summary: Adsorption kinetic studies were conducted using chiral mesoporous materials NGM-1 and NFM-1 for the enantiomeric separation of l- and d-valine, with calcined versions fitting the Langmuir model and exhibiting high sorption capacities. The results and analysis indicate strong adsorbate-adsorbent interaction and the formation of a monolayer of amino acids on the internal mesopore surface for the preferred enantiomers.
Review
Clinical Neurology
Irene Moroni, Alfonso Garcia-Bennett, Julia Chapman, Ronald R. Grunstein, Christopher J. Gordon, Maria Comas
Summary: Conflicting evidence exists on the clinical efficacy of exogenous melatonin for the treatment of sleep disorders, possibly due to differences in melatonin formulations and doses affecting its pharmacokinetics. Future studies should investigate how different pharmacokinetic parameters of melatonin formulations affect the treatment efficacy of sleep and circadian disorders more systematically.
SLEEP MEDICINE REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Irene Moroni, Alfonso E. Garcia-Bennett
Summary: In this study, melatonin was encapsulated in mesoporous silica with the addition of a coating of cellulose acetate phthalate. The release kinetics of melatonin and its metabolism were investigated in simulated gastrointestinal fluids and in an in vitro model of the intestinal tract. The presence of the coating affected the release and absorption of melatonin, as well as its catabolism. The confinement of melatonin in the mesopores had a slight impact on its permeability and metabolism.
Article
Neurosciences
Tik Muk, Allan Stensballe, Oksana Dmytriyeva, Anders Brunse, Ping-Ping Jiang, Thomas Thymann, Per Torp Sangild, Stanislava Pankratova
Summary: Chorioamnionitis is a risk factor for preterm birth and can lead to neurodevelopmental delay and cognitive disorders. This study used pigs as a model to investigate the effects of prenatal lipopolysaccharide (LPS) exposure on the proteome in cerebrospinal fluid (CSF) and brain tissue at birth and postnatally. The results showed changes in CSF protein levels at birth, but most of these changes resolved a few days later. The hippocampus exhibited high neuronal plasticity in response to perinatal inflammation. The findings suggest that CSF protein expression at birth may predict later structural brain damage in preterm infants exposed to various types and durations of chorioamnionitis-related inflammation in utero.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Physical
Inga Kuschnerus, Kalpeshkumar Giri, Juanfang Ruan, Yanan Huang, Nicholas Bedford, Alfonso Garcia-Bennett
Summary: The characterization of the protein corona is crucial for understanding the biological properties of nanomaterials, especially in the case of mesoporous silica particles used as drug delivery excipients. The shape and aspect ratio of the particles have a significant impact on the composition and coverage of the protein corona, which in turn affects the biological properties of the particles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Medicine, Research & Experimental
Ruba Almasri, Hayley B. Schultz, Amalie Moller, Kristen E. Bremmell, Alfonso Garcia-Bennett, Paul Joyce, Clive A. Prestidge
Summary: SBA-15 mesoporous silica (MPS) is widely used in oral drug delivery, but its application in solidifying lipid-based formulations is still underexplored. This study investigates the impact of MPS microporosity on the solubility and oral pharmacokinetics of the prostate cancer drug abiraterone acetate (AbA) and finds that microporosity plays a key role in enhancing AbA solubilization.
MOLECULAR PHARMACEUTICS
(2022)
Article
Neurosciences
Ping-Ping Jiang, Shan-Shan Peng, Stanislava Pankratova, Ping Luo, Ping Zhou, You Chen
Summary: Newborn infants are susceptible to sepsis and inflammation of different organs. Neuroinflammation is associated with long-term adverse neuronal outcomes. This study found significant changes in the CSF proteome under neuroinflammation, which may be related to sepsis-affected neurodevelopment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Nicole L. Henriksen, Karina S. Asmussen, Xiaoyu Pan, Ping-Ping Jiang, Yuki Mori, Line Christiansen, Richard R. Sprenger, Christer S. Ejsing, Stanislava Pankratova, Thomas Thymann
Summary: This study found that the fat source in diet can influence the plasma and hippocampal lipidome in three-day-old piglets, but is unable to improve brain structural and functional impairments induced by IUGR.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Michael Lau, Benjamin Sealy, Valery Combes, Marco Morsch, Alfonso E. Garcia-Bennett
Summary: The integrity of the blood-brain barrier (BBB) is crucial for the health of the nervous system. In this study, we found that loading the compound probucol within mesoporous silica particles (MSP) can enhance its antioxidant effects, thereby protecting the function and integrity of brain endothelial cells. Through in vitro and in vivo experiments using zebrafish models, we demonstrated that probucol-loaded MSPs can significantly reduce cellular damage caused by oxidative stress and inflammation, and decrease the permeability of the BBB.
Article
Neurosciences
Eva Baerends, Katia Soud, Jonas Folke, Anna-Kathrine Pedersen, Simon Henmar, Lisa Konrad, Matthew D. Lycas, Yuki Mori, Bente Pakkenberg, David P. D. Woldbye, Oksana Dmytriyeva, Stanislava Pankratova
Summary: This study evaluated early behavioral, anatomical, and molecular changes in rats following injections of human Aβ oligomers. Social memory impairment and changes in brain structure were observed, indicating possible neuroinflammatory responses and synaptopathy associated with Aβ oligomer injections.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Physiology
Nicole Lind Henriksen, Svend Hoime Hansen, Matthew Domenic Lycas, Xiaoyu Pan, Thomas Eriksen, Lars Sondergaard Johansen, Richard R. Sprenger, Christer Stenby Ejsing, Douglas G. Burrin, Kerstin Skovgaard, Vibeke Brix Christensen, Thomas Thymann, Stanislava Pankratova
Summary: Neonatal cholestasis affects the molecular bile acid and lipid composition of the brain, which may contribute to motor deficits.
PHYSIOLOGICAL REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Corinne Morfill, Stanislava Pankratova, Pedro Machado, Nathalie K. Fernando, Anna Regoutz, Federica Talamona, Alessandra Pinna, Michal Klosowski, Robert J. Wilkinson, Roland A. Fleck, Fang Xie, Alexandra E. Porter, Darya Kiryushko
Summary: A challenge in neurology is the lack of efficient neuroprotectants that can penetrate the blood-brain barrier and target multiple disease mechanisms. In this study, the authors conjugate custom-made peptide dendrimers with gold nanostructures and demonstrate their potential as neuroprotectants, showing protective effects against oxidative stress and cytotoxicity related to Parkinson's and Alzheimer's disease.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Neurosciences
Line I. Christiansen, Gemma C. Ventura, Bo Holmqvist, Karoline Aasmul-Olsen, Sandy E. H. Lindholm, Matthew D. Lycas, Yuki Mori, Jan Bojsen-Moller Secher, Douglas G. Burrin, Thomas Thymann, Per T. Sangild, Stanislava Pankratova
Summary: Preterm infants are at increased risk of impaired neurodevelopment, which may be related to reduced levels of insulin-like growth factor 1 (IGF-1) after birth. This study used preterm pigs as a model to investigate the effects of postnatal IGF-1 supplementation on brain development. The results showed that IGF-1 treatment improved motor function and enhanced GABAergic maturation in the caudate nucleus, but reduced myelination in certain brain regions. These findings suggest that supplemental IGF-1 may support postnatal brain development in preterm infants.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Zahra Khabir, Connie Partalis, Jimit Vijay Panchal, Anand Deva, Aparajita Khatri, Alfonso Garcia-Bennett
Summary: A new delivery vehicle based on encapsulation of cannabidiol within organosilica particles has been proposed, which can release stable cannabidiol and enhance its transdermal penetration. This design opens up a new route for membrane technologies for cannabidiol and other cannabinoid products.
Article
Neurosciences
Line I. Christiansen, Bo Holmqvist, Xiaoyu Pan, Kristine Holgersen, Sandy E. H. Lindholm, Nicole L. Henriksen, Douglas G. Burrin, David Ley, Thomas Thymann, Per Torp Sangild, Stanislava Pankratova
Summary: Very preterm infants with low levels of IGF-1 may benefit from supplemental IGF-1 to improve neurologic outcomes and promote brain maturation.
