Review
Biochemistry & Molecular Biology
Maria Ricci, Andrea Cimini, Maria Rosaria Grivet Fojaja, Mariacristina Ullo, Bruno Carabellese, Viviana Frantellizzi, Ennio Lubrano
Summary: This review focuses on imaging aspects of fibromyalgia, particularly novel approaches in molecular imaging, with an emphasis on neuroimaging. The potential role of functional MRI and different PET tracers in the field of fibromyalgia has been discussed, serving as a comprehensive guide for novel imaging options in research and clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Daniel Kwon, Zhengxing Zhang, Jutta Zeisler, Hsiou-Ting Kuo, Kuo-Shyan Lin, Francois Benard
Summary: The study developed a radiotracer [Ga-68]Ga-BL31 targeting CXCR4, which showed lower kidney retention and excellent imaging contrast, making it suitable for PET imaging and radioligand therapy.
Review
Oncology
Xuying Li, Lixiang Wang, Li Zhang, Fei Tang, Xin Wei
Summary: Choroidal melanomas are the most common ocular malignant tumors worldwide, requiring early diagnosis. The onset of these tumors is insidious, necessitating enucleation; they easily metastasize to the liver, leading to patient mortality. Molecular imaging plays a crucial role in early diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Gabriela Capriotti, Arnoldo Piccardo, Elena Giovannelli, Alberto Signore
Summary: Copper is essential for cancer cell proliferation and tumor angiogenesis. Copper-64 radionuclide (Cu-64) is an emerging diagnostic PET/CT tracer in oncology. It shows potential as a radionuclide precursor for labeling radiopharmaceuticals used in the investigation of neuroendocrine tumors and prostate cancer as an alternative to gallium-68 (Ga-68). Cu-64 emits beta(+) and beta(-) particles along with high-linear-energy-transfer Auger electrons, suggesting its therapeutic potential for radionuclide cancer therapy of copper-avid tumors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Wenbi Yang, Quanlin Sun, Maocai Shang, Song Li, Xiao Hu, Xianwen Hu
Summary: Hepatic perivascular epithelioid cell tumors (PEComas) are rare interstitial tumors that are often misdiagnosed as hepatocellular carcinomas. This case report presents a 61-year-old male patient who had a lesion in the left medial segment of the liver incidentally found during a chest CT examination. Imaging revealed solid components and areas of low-density adipose tissue within the lesion. Magnetic resonance imaging showed areas with unevenly high signal intensity and areas with unevenly low signal intensity in different sequences, and contrast-enhanced T1WI displayed a fast in and fast out enhancement pattern. These distinct imaging features contribute to the diagnosis of hepatic PEComas and distinguish it from hepatocellular carcinoma.
FRONTIERS IN MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Vidumin Dahanayake, Trevor Lyons, Brendan Kerwin, Olga Rodriguez, Christopher Albanese, Erika Parasido, Yichien Lee, Edward Van Keuren, Luxi Li, Evan Maxey, Tatjana Paunesku, Gayle Woloschak, Sarah L. Stoll
Summary: The study focused on enhancing the relaxivity of a manganese and iron-oxo cluster grafted within porous polystyrene nanobeads with increased surface area. The synthesis of the cluster-nanocarrier under miniemulsion conditions resulted in porous nanobeads approximately 70 nm in diameter, leading to higher relaxivity. The stability assessment and synchrotron X-ray fluorescence microscopy showed promising results for in vivo applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Hye Jin Lee, Metti K. Gari, David R. Inman, Zachary T. Rosenkrans, Brian M. Burkel, Aeli P. Olson, Jonathan W. Engle, Reinier Hernandez, Suzanne M. Ponik, Glen S. Kwon
Summary: The study demonstrates that PEGylated FUD peptide has improved tumor exposure in a murine breast cancer model compared to non-PEGylated FUD. PEG-FUD maintains nanomolar binding affinity for FN in vitro and stability for up to 48 hours, showing potential as a therapeutic and imaging agent for breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Cardiac & Cardiovascular Systems
Mahesh K. Vidula, Paco E. Bravo
Summary: Infiltrative cardiomyopathies are diseases that result from specific substances being deposited or abnormally stored in the heart, leading to impaired cardiac function and heart failure. Multimodality imaging is essential for the accurate non-invasive diagnosis of infiltrative cardiomyopathies, which is crucial for ensuring appropriate treatment and prognosis for patients.
Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Oncology
Martin Kocher, Christiane Jockwitz, Philipp Lohmann, Gabriele Stoffels, Christian Filss, Felix M. Mottaghy, Maximilian I. Ruge, Carolin Weiss Lucas, Roland Goldbrunner, Nadim J. Shah, Gereon R. Fink, Norbert Galldiks, Karl-Josef Langen, Svenja Caspers
Summary: This study used structural MRI and amino acid PET in conjunction with brain atlases and elastic registration techniques to investigate the impact of treatment-related brain damage on cognitive functioning in well-functioning WHO Grade III/IV glioma patients. The results showed that T2/FLAIR hyperintensities caused by radiation therapy significantly impaired cognitive performance, especially affecting the left hemisphere functional nodes and fiber tracts, which were highly correlated with verbal episodic memory dysfunction.
Article
Chemistry, Multidisciplinary
Chunjuan Jiang, Le Zhang, Xiaoping Xu, Ming Qi, Jianping Zhang, Simin He, Qiwei Tian, Shaoli Song
Summary: The development of a novel smart agent KN046@F-19-ZIF-8 improves the immune response rate of antibody drugs in tumor treatment and reduces toxic side effects, achieving excellent antitumor efficacy.
Article
Clinical Neurology
Julia Schumacher, Prabesh Kanel, Martin Dyrba, Alexander Storch, Nicolaas Bohnen, Stefan Teipel, Michel J. Grothe
Summary: The study aimed to investigate the relationship between basal forebrain degeneration and cortical acetylcholinesterase activity in Parkinson’s disease, as well as their contribution to cognitive impairment. The findings demonstrated that the hypo-cholinergic Parkinson’s group had significantly reduced posterior basal forebrain volume compared to both the normo-cholinergic Parkinson’s group and the control group. Furthermore, the volume of posterior basal forebrain was significantly associated with cortical acetylcholinesterase activity in Parkinson’s patients, and both cholinergic markers were independently associated with multi-domain cognitive deficits.
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Article
Computer Science, Information Systems
Xiaohang Fu, Lei Bi, Ashnil Kumar, Michael Fulham, Jinman Kim
Summary: Multimodal PET-CT combines PET's sensitivity for tumor detection with CT's anatomical information for cancer assessment. Existing automated segmentation methods are often ineffective, leading to manual segmentation by imaging experts which is labor-intensive and error-prone.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Review
Biochemistry & Molecular Biology
Christophe van de Wiele, Sezgin Ustmert, Bart De Spiegeleer, Pieter-Jan De Jonghe, Mike Sathekge, Maes Alex
Summary: Various potential PET-apoptosis imaging radiopharmaceuticals have been developed to assess the response to cancer treatment. Some of these radiopharmaceuticals showed enhanced uptake in xenografted tumors in mice, but to varying degrees. Two validated radioligands showed favorable characteristics in healthy individuals, but did not significantly affect bone marrow. Further research is needed to evaluate the clinical value of these radiopharmaceuticals for apoptosis imaging in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
M. J. Fowler, J. D. Cotter, B. E. Knight, E. M. Sevick-Muraca, D. I. Sandberg, R. W. Sirianni
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Computer Science, Interdisciplinary Applications
Banghe Zhu, Sunkuk Kwon, John C. Rasmussen, Maritoni Litorja, Eva M. Sevick-Muraca
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Surgery
John C. Rasmussen, Banghe Zhu, John R. Morrow, Melissa B. Aldrich, Aaron Sahihi, Stuart A. Harlin, Caroline E. Fife, Thomas F. O'Donnell, Eva M. Sevick-Muraca
Summary: Near-infrared fluorescence lymphatic imaging showed that lymphatic anatomy and contractile function deteriorate with the severity of venous insufficiency in comparison to normal health subjects. Lymphatic abnormalities in venous insufficiency resemble those in early cancer-acquired lymphedema.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Review
Oncology
Melissa B. Aldrich, John C. Rasmussen, Caroline E. Fife, Simona F. Shaitelman, Eva M. Sevick-Muraca
Article
Immunology
Alexandre E. Malek, Caroline E. Fife, John C. Rasmussen, Ron J. Karni, John R. Morrow, Audrey Wanger, Eva M. Sevick-Muraca, Luis Ostrosky-Zeichner
Summary: Cutaneous tuberculosis caused by skin inoculation of Mycobacterium tuberculosis is rare but can occur in healthcare settings. This case report describes an unusual case of primary cutaneous tuberculosis of the thumb following a needlestick injury, with progression to necrotic granuloma, lymphatic dysfunction, and axillary web syndrome.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Meeting Abstract
Oncology
Melissa B. Aldrich, Meghan E. McWain, Wenyaw Chan, John C. Rasmussen, Sarah DeSnyder, Eva M. Sevick-Muraca, Simona F. Shaitelman
Meeting Abstract
Oncology
Wintana Balema, Janelle Morton, Richard Larson, Fred C. Velasquez, Eva Sevick-Muraca, Wendy A. Woodward
Meeting Abstract
Oncology
Anna R. Vang, Simona F. Shaitelman, Eva M. Sevick-Muraca, Chan Wen-yaw, John C. Rasmussen, Sarah D. DeSnyder, Melissa B. Aldrich
Editorial Material
Nanoscience & Nanotechnology
Eva M. Sevick-Muraca
NATURE NANOTECHNOLOGY
(2022)
Article
Oncology
Carolina Mantilla-Rojas, Fred C. Velasquez, Janelle E. Morton, Leticia C. Clemente, Edwin R. Parra, Carlos Torres-Cabala, Eva M. Sevick-Muraca
Summary: This study demonstrates that combining vaccination and checkpoint blockade immunotherapy delivered through the lymphatics can improve anti-tumor responses in non-immunogenic melanoma models. This method may potentially benefit more patients by directing immune responses within the regional lymph node environment.
Article
Oncology
Melissa B. Aldrich, John C. Rasmussen, Sarah M. DeSnyder, Wendy A. Woodward, Wenyaw Chan, Eva M. Sevick-Muraca, Elizabeth A. Mittendorf, Benjamin D. Smith, Michael C. Stauder, Eric A. Strom, George H. Perkins, Karen E. Hoffman, Melissa P. Mitchell, Carlos H. Barcenas, Lynn E. Isales, Simona F. Shaitelman
Summary: This study investigated the use of near-infrared fluorescence lymphatic imaging (NIRF-LI) surveillance to predict early onset of peripheral lymphatic dysfunction as a predictor of breast cancer-related lymphedema (BCRL). The results showed that dermal backflow can predict the development of BCRL months before arm swelling occurs, enabling early treatment to prevent edema and irreversible tissue changes.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Anna R. Vang, Simona F. Shaitelman, John C. Rasmussen, Wenyaw Chan, Eva M. Sevick-Muraca, Melissa B. Aldrich
Summary: Breast cancer-related lymphedema (BCRL) occurs in approximately 40% of patients after axillary lymph node dissection (ALND), radiation therapy (RT), or chemotherapy. First-line palliative treatment involves the use of compression garments and specialized massage. Reparative microsurgeries are a second-line treatment, but both compression and surgical therapy are most effective in the early stages of LE development. Identifying patients at the highest risk for BCRL would allow for earlier and more effective treatment.
Article
Computer Science, Interdisciplinary Applications
Banghe Zhu, Eva M. Sevick-Muraca, Ryan D. Nguyen, Manish N. Shah
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Medicine, Research & Experimental
Kay T. Pham, Duraisamy Balaguru, Varaha S. Tammisetti, Carlos J. Guevara, John C. Rasmussen, Rodrick C. Zvavanjanja, Robert Hanfland, Eva M. Sevick-Muraca, Melissa B. Aldrich
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2020)
Article
Physiology
John C. Rasmussen, Sunkuk Kwon, Amanda Pinal, Alexander Bareis, Fred C. Velasquez, Christopher F. Janssen, John R. Morrow, Caroline E. Fife, Ron J. Karni, Eva M. Sevick-Muraca
PHYSIOLOGICAL REPORTS
(2020)