Article
Oncology
Eward J. Melis, Jeannette E. F. Zwart-van Rijkom, Toine C. G. Egberts, Bart J. F. van den Bemt, Petronella O. Witteveen, Helga Gardarsdottir
Summary: This study assesses the association between patient satisfaction with information about oral anticancer agents and adherence. The results showed no significant relationship between patient satisfaction with information and adherence, despite the high level of satisfaction with the information. However, 35.5% of patients were found to be non-adherent based on refill data.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Article
Hematology
Christopher Carman, Dessislava N. Nikova, Yumiko Sakurai, Jialan Shi, Valerie A. Novakovic, Jan T. Rasmussen, Wilbur A. Lam, Gary E. Gilbert
Summary: Prior reports have indicated that convex membrane curvature of phosphatidylserine (PS)-containing vesicles enhances the formation of binding sites for factor Va and lactadherin, but the relationship between convex curvature and protein localization on cells remains unknown. In this study, a membrane topology model was developed to explore this relationship further. Results show that the ridges of membranes with maximal curvature selectively bound lactadherin and factor Va, supporting the assembly of prothrombinase complexes.
Review
Computer Science, Information Systems
Britt W. M. van de Burgt, Arthur T. M. Wasylewicz, Bjorn Dullemond, Rene J. E. Grouls, Toine C. G. Egberts, Arthur Bouwman, Erik M. M. Korsten
Summary: This review examines the use of text mining and clinical decision support in clinical practice, discussing their potential benefits, implementation challenges, and barriers. The findings suggest that combining text mining and clinical decision support can improve diagnostic and therapeutic processes, leading to increased patient safety. However, there are still barriers to implementation that need to be addressed through further research.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Review
Cell Biology
Juntao Fang, Alain de Bruin, Andreas Villunger, Raymond Schiffelers, Zhiyong Lei, Joost P. G. Sluijter
Summary: Polyploid cells, containing more than one set of chromosome pairs, are common in nature. They provide cells with several advantages, including increased cell size, organ growth, tissue homeostasis, and enhanced tolerance to genomic stress and apoptotic signals. This article focuses on the reasons for polyploidy, the stress responses and molecular signals involved, as well as its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.
Article
Genetics & Heredity
Corine de Jong, Gerarda J. M. Herder, Simone W. A. van Haarlem, Femke S. van der Meer, Anne S. R. van Lindert, Alexandra ten Heuvel, Jan Brouwer, Toine C. G. Egberts, Vera H. M. Deneer
Summary: This study investigated the genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN) in non-small cell lung cancer (NSCLC) patients. It revealed that the GG genotype of TRPV1 gene (rs879207) is associated with an increased risk of severe neuropathy. Additionally, concomitant use of paclitaxel and GG genotype also showed a significant association with severe CIPN.
Article
Health Care Sciences & Services
Anna G. M. J. Zondag, T. Katrien J. M. Groenhof, Rieke van der Graaf, Wouter van Solinge, Michiel L. Bots, Saskia Haitjema, UCC CVRM study grp
Summary: The Utrecht Cardiovascular Cohort - Cardiovascular Risk Management (UCC-CVRM) may have participation bias due to variations in informed consent.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Biophysics
T. (Tim) Bognar, J. S. (Jurjen) Kingma, E. H. (Erin) Smeijsters, K. C. M. (Kim) van der Elst, C. T. M. (Klaartje) de Kanter, C. A. (Caroline) Lindemans, A. C. G. (Toine) Egberts, I. H. (Imke) Bartelink, A. (Arief) Lalmohamed
Summary: This observational study assessed the impact of therapeutic drug monitoring on busulfan exposure in pediatric patients undergoing hematopoietic cell transplantation. The results showed no significant difference in achieving therapeutic busulfan exposure between the two monitoring regimens, suggesting that day 1-guided dosing may be sufficient with subsequent monitoring if needed.
BONE MARROW TRANSPLANTATION
(2023)
Article
Immunology
Marjon V. Verschueren, Talitha Dijs, Judith L. Gulikers, Ard van Veelen, Sander Croes, Lizza E. L. Hendriks, Adrianus A. J. Smit, Lourens T. Bloem, Antoine C. G. Egberts, Ewoudt M. W. van de Garde, Bas J. M. Peters
Summary: Real-world stage III NSCLC patients who received durvalumab after CRT had better outcomes than those who received CRT alone. Longer PFS in real-world versus trial may be due to follow-up differences.
Article
Chemistry, Multidisciplinary
Nazma F. Ilahibaks, Arif I. Ardisasmita, Songpu Xie, Anders Gunnarsson, Joseph Brealey, Pieter Vader, Olivier G. de Jong, Saskia de Jager, Niek Dekker, Ben Peacock, Raymond M. Schiffelers, Joost P. G. Sluijter, Zhiyong Lei
Summary: Extracellular vesicles (EVs) are being explored as biocompatible drug delivery vehicles for their ability to deliver bioactive cargo to recipient cells. However, effective methods for loading and unloading proteins inside EVs remain a challenge. In this study, we present the Technology Of Protein delivery through Extracellular Vesicles (TOP-EVs) as an efficient tool for intracellular protein delivery mediated by EVs. Our results demonstrate the versatility and potential of TOP-EVs for protein-based therapeutics in vitro and in vivo.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Laura E. Swart, Marcel H. A. M. Fens, Anita van Oort, Piotr Waranecki, L. Daniel Mata Casimiro, David Tuk, Martijn Hendriksen, Luca van den Brink, Elizabeth Schweighart, Cor Seinen, Ryan Nelson, Anja Krippner-Heidenreich, Tom O'Toole, Raymond M. Schiffelers, Sander Kooijmans, Olaf Heidenreich
Summary: Lipid nanoparticles (LNPs) are rapidly evolving as promising delivery systems for oligonucleotides, including siRNAs. In this study, LNPs were specifically targeted to hematopoietic progenitor cells in the bone marrow using a modified tripeptide ligand. Functionalized LNPs showed improved uptake and delivery of siRNA in patient-derived leukemia cells, as well as increased accumulation and retention in the bone marrow. These findings suggest the potential of LNPs for targeted therapy in leukemia and other hematological disorders.
Article
Hematology
Anouk A. M. T. Donners, Konrad van der Zwet, Carin M. A. Rademaker, Toine C. G. Egberts, Roger E. G. Schutgens, Kathelijn Fischer
Summary: This study evaluated the efficacy of entire-vial dosing of emicizumab in a real-world setting. The results demonstrated that this dosing method can achieve therapeutic plasma concentrations, effectively control bleeding, and reduce drug waste.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Chemistry, Multidisciplinary
Emile F. van Vliet, Maarten J. Knol, Raymond M. Schiffelers, Massimiliano Caiazzo, Marcel H. A. M. Fens
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons, causing dopamine deficiency and motor symptoms. Current treatment using L-DOPA has limitations and side effects. Encapsulation of L-DOPA into nanoparticles can protect it and improve delivery to the brain, reducing required dosages and side effects. Alternative delivery methods, such as intravenous administration and transdermal delivery, enhance therapeutic effects. This review discusses recent advances and future perspectives on NP-mediated L-DOPA delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
C. M. van Kammen, S. J. van Woudenberg, R. Schiffelers, F. Terstappen, A. T. Lely
Summary: Preeclampsia and fetal growth restriction are pregnancy complications that can be treated with nanomedicines, which regulate drug interaction with the placenta to enhance treatment efficacy and minimize fetal exposure. Liposomes and polymeric drug delivery systems show promising results in preventing trans-placental passage of nanomedicines, while quantum dots and silicon nanoparticles have limited research in placental insufficiency syndromes. Animal studies demonstrate positive effects on maternal and fetal health, but results are influenced by various factors. Further research is needed to understand the pathophysiology of these complex diseases and ensure the safety and efficacy of nanomedicines before clinical implementation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Peripheral Vascular Disease
L. Malin Overmars, Joost M. Mekke, Wouter W. van Solinge, Saskia C. A. De Jager, Cornelia A. R. Hulsbergen-Veelken, Imo E. Hoefer, Dominique P. V. de Kleijn, Gert J. de Borst, Sander W. van der Laan, Saskia Haitjema
Summary: This study examined blood cell characteristics (BCCs) in relation to major adverse cardiovascular events (MACE) after carotid endarterectomy (CEA) and identified biomarkers reflecting inflammatory processes that may contribute to an increased risk of MACE.
ATHEROSCLEROSIS PLUS
(2023)
Article
Chemistry, Multidisciplinary
Ye Zeng, Mariona Estape Senti, M. Clara I. Labonia, Panagiota Papadopoulou, Maike A. D. Brans, Inge Dokter, Marcel H. Fens, Alain van Mil, Joost P. G. Sluijter, Raymond M. Schiffelers, Pieter Vader, Alexander Kros
Summary: This study demonstrates the efficient delivery of mRNA-LNPs to difficult-to-transfect cardiomyocytes using fusogenic coiled-coil peptides. Local administration via intramyocardial injection significantly enhances mRNA delivery and protein expression. These findings have the potential to advance regenerative therapies for heart failure.