Review
Multidisciplinary Sciences
Hamdi Nsairat, Dima Khater, Fadwa Odeh, Fedaa Al-Adaileh, Suma Al-Taher, Areej M. Jaber, Walhan Alshaer, Abeer Al Bawab, Mohammad S. Mubarak
Summary: Advancements in material science and bionanotechnology have driven the use of nanoparticles in healthcare to improve diagnosis, monitoring, and therapy. Lipid nanostructures play a crucial role in combating brain tumors, with research focusing on solid lipid nanoparticles and nanostructured lipid carriers for overcoming the blood brain barrier and increasing effectiveness.
Article
Chemistry, Medicinal
Hadel A. Abo El-Enin, Alaa S. Tulbah, Hany W. Darwish, Rania Salama, Ibrahim A. Naguib, Heba A. Yassin, Hend Mohamed Abdel-Bar
Summary: The feasibility of using lipid-polymer hybrid (LPH) nanocarriers for intranasal delivery of ziprasidone (ZP) was explored. ZP-loaded LPH with optimized particle size and drug encapsulation efficiency were prepared. The studies demonstrated the efficacy of LPH in crossing the blood-brain barrier, achieving higher targeting efficiency and better antipsychotic activity compared to intravenous administration.
Article
Chemistry, Multidisciplinary
Xinyuan Zhao, Bing Guo, Wenjuan Sun, Jinhua Yu, Li Cui
Summary: Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC) is driven by squalene epoxidase (SQLE), which operates through a cholesterol-dependent pathway. SQLE stabilizes c-Myc protein and prevents its degradation, leading to the activation of c-Myc transcriptional activity. Inhibition of SQLE disrupts the binding of Akt to lipid rafts, deactivates Akt, and destabilizes c-Myc. In a mouse model, SQLE is found to be critical for HNSCC initiation and progression. The combination of terbinafine and cisplatin shows promising synergistic effects in arresting tumor growth. These findings provide insights into SQLE-mediated cisplatin resistance and propose a potential therapeutic avenue for HNSCC patients.
Review
Pharmacology & Pharmacy
Rahul Rimal, Prachi Desai, Rasika Daware, Aisa Hosseinnejad, Jai Prakash, Twan Lammers, Smriti Singh
Summary: The tumor microenvironment, specifically cancer-associated fibroblasts (CAF), plays a critical role in tumor progression and drug resistance. This review presents imaging techniques for visualizing CAF and CAF-induced fibrosis, as well as compounds known to modulate CAF activity. Additionally, CAF-targeted therapies and CAF-modulating nanocarriers are discussed, along with the challenges and prospects for these treatments.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biophysics
Maria Ines Teixeira, Carla M. Lopes, Maria Helena Amaral, Paulo C. Costa
Summary: The blood-brain barrier restricts the entry of therapeutic agents into the brain, posing challenges for the treatment of neurological diseases. Nanocarriers, such as lipid-based systems, have been explored to overcome this limitation and improve drug delivery to the central nervous system. By modifying the surface of nanocarriers with ligands that interact with the blood-brain barrier, their uptake and penetration into the brain can be enhanced. This review provides an overview of active targeting in brain drug delivery and highlights the potential of functionalized lipid nanocarriers for treating brain diseases.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemical Research Methods
Jacob D. Bibik, Sarathi M. Weraduwage, Aparajita Banerjee, Ka'shawn Robertson, Roberto Espinoza-Corral, Thomas D. Sharkey, Peter K. Lundquist, Bjorn R. Hamberger
Summary: This study establishes a platform for sustainable production of squalene in plants, which significantly improves the yield compared to previous methods and lays the foundation for the production of higher-value triterpenoids.
ACS SYNTHETIC BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Luyao Wang, Youyuan Shi, Jingzhen Jiang, Chan Li, Hengrui Zhang, Xinhui Zhang, Tao Jiang, Liang Wang, Yinyan Wang, Lin Feng
Summary: The blood-brain barrier (BBB) poses a significant challenge for drug delivery to brain tumors. Recent research in micro- and nanotechnology has shown that nano drug-targeted delivery technologies have the potential to overcome this challenge. This review provides a detailed understanding of the BBB, summarizes recent research topics on drug delivery carriers for brain tumors, evaluates the effectiveness of targeted therapy, and discusses the challenges and future prospects of developing brain tumor drug delivery systems.
Article
Biotechnology & Applied Microbiology
Xinyang Li, Yixin Li, Yiliang Zhou, Jiamin Wu, Zhifeng Zhao, Jiaqi Fan, Fei Deng, Zhaofa Wu, Guihua Xiao, Jing He, Yuanlong Zhang, Guoxun Zhang, Xiaowan Hu, Xingye Chen, Yi Zhang, Hui Qiao, Hao Xie, Yulong Li, Haoqian Wang, Lu Fang, Qionghai Dai
Summary: DeepCAD-RT is a real-time denoising method for fluorescence time-lapse images, which uses self-supervised deep learning for noise suppression. Compared to traditional methods, DeepCAD-RT significantly reduces the number of network parameters, memory consumption, and processing time, and achieves high imaging signal-to-noise ratio with one-tenth of the photons. In various photon-limited experiments, DeepCAD-RT demonstrates its utility in morphological and functional interrogation of biological dynamics.
NATURE BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain
Summary: This article discusses the challenges of treating central nervous system disorders using traditional delivery methods and explores the use of intranasal drug administration to overcome the blood-brain barrier. Advanced drug delivery tools and intranasal administration have the potential to improve the efficacy of antipsychotic drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yuan Gao, Rui Wang, Lixia Zhao, Anchang Liu
Summary: Malignant glioma is a crucial part among all central nervous diseases, with high fatality and disability rates. Various therapeutic strategies, especially related to chemotherapy, are hindered by the blood-brain barrier. By studying ways to bypass the barrier and utilizing natural polymeric materials for drug delivery, advancements in treating malignant glioma are promising.
JOURNAL OF DRUG TARGETING
(2021)
Review
Pharmacology & Pharmacy
Xihui Gao, Jinliang Xu, Tingting Yao, Xiaoxiao Liu, Hanchang Zhang, Changyou Zhan
Summary: The blood-brain barrier (BBB) serves as a crucial physiological barrier that restricts the exchange of substances between blood and brain tissues. Peptide decorated nanocarriers have shown promise in overcoming the BBB for diagnosis and therapy of brain diseases. However, challenges related to stability, safety, and immunocompatibility need to be addressed for their clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Conor McQuaid, Andrea Halsey, Maeva Dubois, Ignacio Romero, David Male
Summary: Targeting therapeutic agents to specific tissues is crucial for new disease treatments, with the transferrin receptor being a potential target due to its presence on dividing cells and brain endothelium. This study compared different polypeptides for their ability to bind to brain endothelium and target therapeutic agents to the CNS. The findings showed that attaching a TfR-targeting polypeptide significantly increased endocytosis rates by brain endothelium and enhanced nanoparticle movement across cells.
Article
Pharmacology & Pharmacy
Alice Brookes, Liuhang Ji, Tracey D. Bradshaw, Michael Stocks, David Gray, James Butler, Pavel Gershkovich
Summary: This review explores the feasibility of oral lipid-based drug delivery to the brain and discusses various lipids that can potentially be delivered orally. Current data suggests that oral administration can increase the permeability of the blood-brain barrier (BBB), and further research is needed to investigate the use of lipid-based drug delivery for brain targeting.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Leonardo Delello Di Filippo, Juliana Hofstatter Azambuja, Jessyca Aparecida Paes Dutra, Marcela Tavares Luiz, Jonatas Lobato Duarte, Luiza Ribeiro Nicoleti, Sara Teresinha Olalla Saad, Marlus Chorilli
Summary: Glioblastoma multiforme (GBM) is the most common primary brain cancer with aggressive development and increasing resistance to drugs like temozolomide (TMZ). Functionalized nanocarriers can serve as an efficient and safe strategy for delivering TMZ, improving its biopharmaceutical properties and potentially repurposing its use in anti-GBM therapy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Yu-Chen Lo, Wen-Jen Lin
Summary: The study utilized a peptide-conjugated nano-delivery system to enhance penetration into tumor cells by overcoming the blood brain barrier. NPs conjugated with T7 peptide showed higher accumulation in the brain and lower biodistribution in nontarget tissues. The benefit of T7 peptide as a targeting ligand for NPs across the BBB was elucidated in this study.
Article
Oncology
Clarissa C. Pasiliao, Che-Wei A. Chang, Brent W. Sutherland, Shannon M. Valdez, David Schaeffer, Donald T. Yapp, Sylvia S. W. Ng
Article
Chemistry, Inorganic & Nuclear
Caterina F. Ramogida, Jinhe Pan, Cara L. Ferreira, Brian O. Patrick, Karla Rebullar, Donald T. T. Yapp, Kuo-Shyan Lin, Michael J. Adam, Chris Orvig
INORGANIC CHEMISTRY
(2015)
Meeting Abstract
Oncology
Mario Jardon, Steve Kalloger, Christina Iggulden, Nancy Erro Go, Paalini Sathiyaseelan, Donald Yapp, Daniel John Renouf, David Schaeffer, Sharon Gorski
JOURNAL OF CLINICAL ONCOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Robert Neijzen, May Q. Wong, Navdeep Gill, He Wang, Tamanna Karim, Malathi Anantha, Dita Strutt, Dawn Waterhouse, Marcel B. Bally, Isabella T. Tai, Sylvia S. W. Ng, Donald T. Yapp
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Chemistry, Multidisciplinary
M. Verreault, M. Wehbe, D. Strutt, D. Masin, M. Anantha, D. Walker, F. Chu, I. Backstrom, J. Kalra, D. Waterhouse, D. T. Yapp, M. B. Bally
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Peripheral Vascular Disease
Donald T. Yapp, May Q. Wong, Alastair H. Kyle, Shannon M. Valdez, Jenny Tso, Andrew Yung, Piotr Kozlowski, David A. Owen, Andrzej K. Buczkowski, Stephen W. Chung, Charles H. Scudamore, Andrew I. Minchinton, Sylvia S. W. Ng
Article
Multidisciplinary Sciences
Wieslawa H. Dragowska, Mihaela Ginj, Piotr Kozlowski, Andrew Yung, Thomas J. Ruth, Michael J. Adam, Vesna Sossi, Marcel B. Bally, Donald T. T. Yapp
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Louis-Bastien Weiswald, Mohammad R. Hasan, John C. T. Wong, Clarissa C. Pasiliao, Mahbuba Rahman, Jianhua Ren, Yaling Yin, Samuel Gusscott, Sophie Vacher, Andrew P. Weng, Hagen F. Kennecke, Ivan Bieche, David F. Schaeffer, Donald T. Yapp, Isabella T. Tai
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jack M. Webster, Christine A. Morton, Bruce F. Johnson, Hua Yang, Michael J. Rishel, Brian D. Lee, Qing Miao, Chittari Pabba, Donald T. Yapp, Paul Schaffer
JOURNAL OF NUCLEAR MEDICINE
(2014)
Article
Engineering, Chemical
Courtney van Ballegooie, Alice Man, Irene Andreu, Byron D. Gates, Donald Yapp
Article
Pharmacology & Pharmacy
Courtney van Ballegooie, Alice Man, Alessia Pallaoro, Marcel Bally, Byron D. Gates, Donald T. Yapp
Summary: In this study, a novel drug-delivery system utilizing external beam radiation for triggered release was developed. Zein protein and gold particles were used to create nanoparticles, with gold particles leading to significant alterations to the protein structure and promoting the release of encapsulated drugs.
Meeting Abstract
Chemistry, Multidisciplinary
Alessia Pallaoro, Wieslawa Dragowska, Byron Gates, Donald Yapp
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Oncology
Ada W. Y. Leung, Chansey J. Veinotte, Nicole Melong, Min Hee Oh, Kent Chen, Katey S. S. Enfield, Ian Backstrom, Corinna Warburton, Donald Yapp, Jason N. Berman, Marcel B. Bally, William W. Lockwood
CLINICAL CANCER RESEARCH
(2017)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
David Perrin, Kuo-shyan Lin, Francois Benard, Donald Yapp, Zhibo Liu, Maral Pourghiasian, Joseph Lau, Zhengxing Zhang, Silvia Jenni
JOURNAL OF NUCLEAR MEDICINE
(2015)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Hua Yang, Qing Miao, Silvia Jenni, Milena Colovic, Bruce Johnson, Michael Rishel, Donald Yapp, Jack Webster, Francois Benard, Paul Schaffer
JOURNAL OF NUCLEAR MEDICINE
(2015)