Article
Oncology
Alessandro Parodi, Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva, Tatiana Borodina, Roman Akasov, Anastasia Frolova, Vladimir Chulanov, Andrey A. Zamyatnin Jr
Summary: In order to increase the accumulation of drugs in tumors, various nanocarriers have been designed. The development of biomimetic nanomedicine allows the generation of nanoparticles with the same characteristics as cells that naturally infiltrate tumors. Moreover, strategies such as cell membrane transfer and biomimetic targeting can enhance the targeting efficiency of drugs in tumors.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Medicinal
Xin Deng, Ruiyao Mai, Chenyu Zhang, Dianbao Yu, Yichang Ren, Gang Li, Binbin Cheng, Ling Li, Zhiqiang Yu, Jianjun Chen
Summary: A novel PDC was synthesized to intelligently deliver paclitaxel, showing higher cellular uptake and cytotoxicity in experiments, with less toxicity to normal cells and the ability to overcome paclitaxel resistance. The results demonstrated that this new PDC had better in vivo anti-tumor efficacy than paclitaxel.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Wen-Fang Song, Diwei Zheng, Si-Min Zeng, Xuan Zeng, Xian-Zheng Zhang
Summary: The special bacteria-enriched tumor environment can be utilized as a target for drug delivery, leading to an efficient cancer treatment strategy.
Review
Chemistry, Multidisciplinary
Yasamin Davatgaran Taghipour, Amir Zarebkohan, Roya Salehi, Fariborz Rahimi, Vladimir P. Torchilin, Michael R. Hamblin, Alexander Seifalian
Summary: The lack of efficient strategies for targeted delivery and accumulation of therapeutic cargoes in the tumor microenvironment (TME) is a key issue in the treatment of solid tumors. This review focuses on dual targeting approaches, which combine biological strategies and physicochemical responsive smart delivery strategies, to increase the accumulation of nanoparticles within the TME and improve targeting efficiency towards cancer cells. The efficiency and rationale behind the choice of ligands for dual targeting strategies are critically reviewed. New approaches for smart drug delivery, including TME-specific responsive linkers and camouflaged nanoparticles, are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
Bijaideep Dutta, K. C. Barick, P. A. Hassan
Summary: The use of nanomaterials in cancer therapy has the potential to significantly impact drug delivery by enhancing drug concentration at tumor sites, improving drug content in formulations, and increasing colloidal stability. Nanocarriers with tumor-specific moieties can target cancer cells with high affinity and accuracy, overcoming issues such as aimless drug biodistribution and undesired toxicity. Active drug targeting through nanocarriers is a promising strategy for improving cancer management.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Menghuan Tang, Kai Lin, Mythili Ramachandran, Longmeng Li, Hongye Zou, Huzhi Zheng, Zhao Ma, Yuanpei Li
Summary: This study developed lipid-small molecule hybrid nanoparticles for imaging and treatment of glioma. These hybrid nanoparticles have low toxicity, enhanced photodynamic therapy effects, and the ability to visualize drug distribution and tumor imaging.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Ilaria Arduino, Zehua Liu, Rosa Maria Iacobazzi, Angela Assunta Lopedota, Antonio Lopalco, Annalisa Cutrignelli, Valentino Laquintana, Letizia Porcelli, Amalia Azzariti, Massimo Franco, Helder A. Santos, Nunzio Denora
Summary: Solid lipid nanoparticles (SLNs) can effectively deliver drugs, and their production through microfluidics enables continuous and replicable manufacturing. Surface functionalized SLNs with iRGD peptide show enhanced cellular uptake and cytotoxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Juan Zhang, Wenjing Zhang, Mengsi Yang, Weiwei Zhu, Ming Li, Ao Liang, Hui Zhang, Ti Fang, Xian-En Zhang, Feng Li
Summary: This study explored the impact of tumor progression stages on the targeting efficiency of PEGylated viral nanoparticles using a colorectal cancer model. The results showed a decrease in tumor targeting efficiency with tumor progression.
Article
Instruments & Instrumentation
Ruchika Goyal, Gaurav Jerath, Aneesh Chandrasekharan, Yvonne Christian, T. R. Santhosh Kumar, Vibin Ramakrishnan
Summary: This study developed a peptide-based drug delivery unit with a tumor homing domain chemically linked to a cell-penetrating domain, showing selective toxicity to MDA-MB-231 breast cancer cells and superior penetration in three-dimensional MDA-MB-231 tumorospheres.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Mingming Song, Bin Zhu, Shuang Qiu, Jiameng Tian, Jianning Li, Daling Chen, Chang Liu
Summary: IL4RPep-1-targeting peptide nanoparticles efficiently deliver afuresertib and celecoxib to melanoma cells, promoting cell apoptosis and immune response, while reducing adverse reactions.
APPLIED MATERIALS TODAY
(2023)
Article
Biochemistry & Molecular Biology
Ikuma Hori, Hideyoshi Harashima, Yuma Yamada
Summary: Delivering drugs to mitochondria, the main source of energy in neurons, is a potential therapeutic strategy for neurodegenerative diseases. This paper focuses on the efficient delivery of the drug berberine (BBR) into mitochondria using a lipid nanoparticle and its pharmacological action in Neuro2a cells, showing increased ATP production and expression of mitochondrial ubiquitin ligase (MITOL). The findings highlight the importance of enhancing the accumulation of BBR in mitochondria for improved therapeutic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Bhavya Surekha, Naga Sreenu Kommana, Sunil Kumar Dubey, A. V. Pavan Kumar, Rahul Shukla, Prashant Kesharwani
Summary: PAMAM dendrimers are novel polymeric structures with defined nano-size and multiple active functional groups, ideal for cancer therapy. Their modifiable surface functionalities and high drug encapsulation rate make them widely used in drug delivery and gene therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Abdul Rahim Ferhan, Soohyun Park, Hyeonjin Park, Hyunhyuk Tae, Joshua A. Jackman, Nam-Joon Cho
Summary: This article focuses on the development of next-generation lipid-based nanoparticles from a nanoarchitectonics perspective, analyzing the design, nucleic acid encapsulation methods, scalable production, and application prospects. It also compares and contrasts different nanoarchitectures, such as traditional lipid nanoparticles, lipoplexes, and bicelles, and evaluates the current development status and possible future directions in overcoming clinical translation challenges and exploring new application opportunities.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liyi Fu, Xianwu Hua, Xingya Jiang, Jinjun Shi
Summary: The study presents a multistage nanoparticle strategy for systemic and cytosolic protein delivery to tumor cells by encapsulating TG-modified saporin into pH-responsive polymeric NPs for effective cancer treatment. The method showed potent inhibition of lung cancer cell growth both in vitro and in vivo, indicating its potential for clinical applications in protein therapy for cancer treatment.
Article
Multidisciplinary Sciences
Alexander A. Svoronos, Donald M. Engelman
Summary: The study investigates the determinants of pHLIP insertion, targeting, and delivery through computational modeling. It develops a mathematical model to describe the transmembrane insertion process and integrates it into a pharmacokinetic model to predict the biodistribution of pHLIPs. The analysis explores how changing pHLIP properties can influence tumor targeting and delivery efficacy, predicting optimal pHLIP phenotypes for superior tumor targeting and delivery capabilities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Biomedical
Yuhan Zhou, Ting Ye, Chengzhi Ye, Chao Wan, Siyue Yuan, Yushuai Liu, Tianyu Li, Fagang Jiang, Jonathan F. Lovell, Honglin Jin, Jing Chen
Summary: This study demonstrates that different treatment methods can generate cell-derived secretions (CDS) with different effects. Among them, HOCl treatment generated CDS with the strongest stimulatory effect on immune cells. Loading HOCl-CDS into a hydrogel promoted tumor cell death and activation of immune cells, leading to inhibition of tumor growth and prolonged survival in mice. Furthermore, hydrogel-delivered HOCl-CDS enhanced the antitumor effects of immune checkpoint blockade.
BIOACTIVE MATERIALS
(2022)
Article
Medicine, Research & Experimental
Miffy H. Y. Cheng, Marta Overchuk, Maneesha A. Rajora, Jenny W. H. Lou, Ying Chen, Martin G. Pomper, Juen Chen, Gang Zheng
Summary: This study presents a theranostic nanotexaphyrin for PSMA-targeted radionuclide imaging and focal PDT, achieved through the chelation of metal isotopes (In, Lu). The optimized metalated nanotexaphyrin showed excellent stability and potent singlet oxygen generation, with preferential accumulation in PSMA+ prostate tumors and successful inhibition of tumor growth in a xenograft model.
MOLECULAR PHARMACEUTICS
(2022)
Review
Immunology
Yushuai Liu, Yuanyuan Geng, Beilei Yue, Pui-Chi Lo, Jing Huang, Honglin Jin
Summary: Cancer immunotherapy using injectable hydrogels as a platform to target the immunosuppressive tumor microenvironment can enhance treatment efficacy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Anita Bakrania, Gang Zheng, Mamatha Bhat
Summary: This review highlights the progress, challenges, and targeting opportunities in HCC nanomedicine based on the growing literature in recent years. However, the translation of nanotheranostics in HCC is complicated by factors such as molecular heterogeneity and concomitant liver dysfunction.
Article
Engineering, Environmental
Zhan Tuo, Qianyuan He, Zhanjie Zhang, Yiyu Wang, Jinfeng Sun, Qi Wei, Yu Hu, Jonathan F. Lovell, Honglin Jin, Kunyu Yang
Summary: The RP@RMs vaccine, constructed using irradiated cancer cell membrane and a nanoscale delivery system loaded with a TLR-7 agonist, showed enhanced antitumor immune response and improved efficacy of anti-PD-1 treatment.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
David Chapron, Juan Chen, Gang Zheng, Veronique Rosilio
Summary: Photodynamic therapies combine the action of a photosensitizer, molecular oxygen, and light to destroy infectious sites and tumors. Incorporating photosensitizers in nanocarriers allows better control of their distribution in tissues and increases concentration in the illuminated area. This study highlights the importance of characterizing the interfacial properties of porphyrin derivatives and their interaction with the oil to design stable nanoemulsions with well-controlled optical properties.
Correction
Medicine, Research & Experimental
Miffy H. Y. Cheng, Marta Overchuk, Maneesha A. Rajora, Jenny W. H. Lou, Ying Chen, Martin G. Pomper, Juan Chen, Gang Zheng
MOLECULAR PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Hilde Harb Buzza, Fernanda Alves, Ana Julia Barbosa Tome, Juan Chen, Giulia Kassab, Jiachuan Bu, Vanderlei Salvador Bagnato, Gang Zheng, Cristina Kurachi
Summary: NewPS-aPDT is a safe and effective antimicrobial photosensitizer against biofilms. In experiments, NewPS showed high bactericidal efficacy in suspensions of Streptococcus pneumoniae and Staphylococcus aureus, and enhanced antibacterial effect in S. aureus biofilms with a higher concentration of 100 mu M, longer incubation time, and higher light dose. In a murine-infected wound model, NewPS-aPDT demonstrated better therapeutic efficacy and faster tissue healing compared to other treatment groups.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Keegan Guidolin, Lili Ding, Juan Chen, Gang Zheng
Summary: This study aims to develop a clinically viable protocol for nanoparticle-based photodynamic therapy (PDT) in the treatment of colorectal cancer. The study finds that nanoparticle-based PDT effectively ablates colorectal cancer tumors, can be delivered after a relatively short drug-light interval (DLI), and safety concerns can be mitigated through specific delivery methods. These findings lay the foundation for future clinical trials investigating the use of PDT as a component of multi-modal approaches to treat colorectal cancer.
ADVANCED THERAPEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Marta Overchuk, Robert A. Weersink, Brian C. Wilson, Gang Zheng
Summary: Tumoricidal photodynamic (PDT) and photo-thermal (PTT) therapies use light to eliminate cancer cells with precision. The combination of PDT and PTT shows potential due to their different mechanisms of action. Recent developments in multimodal nanoparticles further enhance their efficacy. This review discusses the limitations of each modality alone and how combining them can improve treatment efficacy and safety. It also analyzes the design strategies of dual PDT/PTT nanoparticles and the impact of treatment sequence and dose on treatment response. Additionally, it provides guidelines to elucidate the mechanisms underlying PDT/PTT interactions.
Article
Chemistry, Multidisciplinary
Yulin Mo, Miffy H. Y. Cheng, Andrew D'Elia, Katie Doran, Lili Ding, Juan Chen, Pieter R. Cullis, Gang Zheng
Summary: A strategy called LASER was developed to achieve siRNA release within cells by activating the molecules within lipid nanoparticles using laser light. This approach improved the effectiveness of gene therapy.
Editorial Material
Biochemical Research Methods
Goncalo J. L. Bernardes, Peng Zou, Zhifei Dai, Erin Lavik, Jan van Hest, Gang Zheng, Nathan Quinn, Christina M. MacLaughlin, Theresa M. Reineke
BIOCONJUGATE CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Giulia Kassab, Neha Manav, Layla Pires, Miffy H. Y. Cheng, Yulin Mo, Hilde H. Buzza, Iti Gupta, Juan Chen, Gang Zheng
Summary: This study presents an improved photosensitizer system for antimicrobial photodynamic therapy (aPDT) by adjusting the structural components and compounds. The incorporation of higher cholesterol and PEG-lipid in the formulations enhances the potency against Staphylococcus aureus. Ethylenediaminetetraacetic acid (EDTA)-lipid significantly enhances aPDT efficacy but also increases toxicity toward host cells. Introducing the cationic lipid 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) improves interaction with bacteria but negatively impacts stability.
Article
Chemistry, Multidisciplinary
Maneesha A. Rajora, Alexander Dhaliwal, Mark Zheng, Victor Choi, Marta Overchuk, Jenny W. H. Lou, Carly Pellow, David Goertz, Juan Chen, Gang Zheng
Summary: Microbubble-enabled focused ultrasound has revolutionized drug delivery capabilities, but the lack of systematic studies on microbubble shell pharmacokinetics hinders progress in the field. This study develops a method to radiolabel microbubbles and investigates the impact of microbubble composition and ultrasound on drug delivery. The findings provide insights into the design and safety of the microbubble platform.
