Article
Biochemistry & Molecular Biology
Changdong Wang, Yanxi Shen, Yongping Ma
Summary: This study comprehensively identified and quantified protein expression profiling in gastric cancer cells treated with BF-TK/GCV for the first time. The results showed that BF-TK/GCV inhibited tumor metastasis and downregulated the expression of metastasis-related proteins, as demonstrated by immunohistochemistry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Etienne E. Muller, Dumisile Maseko, Ranmini S. Kularatne
Summary: This study conducted phenotypic and genotypic surveillance on ACV resistance in HSV-2 derived from genital ulcer samples collected in a primary healthcare facility in South Africa. The results revealed no resistance-associated mutations, but identified several known natural polymorphisms and amino acid changes of unknown significance. All cultivable HSV-2 isolates showed susceptibility to ACV.
ANTIVIRAL RESEARCH
(2022)
Article
Polymer Science
Yuliang Lu, Dongtao Liu, Xinjie Wei, Jiming Song, Qiaogang Xiao, Kezheng Du, Xinbo Shi, Haiyang Gao
Summary: Coil-rod copolymers with a dendritic polyethylene core and multiple helical poly(gamma-benzyl-L-glutamate) arms were successfully prepared by palladium-catalyzed copolymerization and ring-opening polymerization. These copolymers could form thermoreversible gels in toluene solvent, and the dendritic topology of the core increased the critical gelation concentrations. The self-assembled fibers formed a twisted flat ribbon structure through a nanoribbon mechanism and exhibited more heterogeneity and branching than previously observed fibers.
Article
Chemistry, Physical
Neha Chaudhary, Anil Kumar Nain
Summary: In this study, physicochemical properties of binary mixtures of PEG 400 with benzyl methacrylate were evaluated using experimentally measured data. The excess properties were correlated with the Redlich-Kister polynomial equation to discuss intermolecular interactions. Theoretical mixing rules for correlating refractive indexes were assessed and compared with experimental data.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Katharina Woess, Yuchen Sun, Hanae Morio, Anna Stierschneider, Anna Kaufmann, Stefan Hainzl, Lisa Trattner, Thomas Kocher, Birgit Tockner, Victoria Leb-Reichl, Markus Steiner, Gabriele Brachtl, Andrew P. South, Johann W. Bauer, Julia Reichelt, Tomomi Furihata, Verena Wally, Ulrich Koller, Josefina Pinon Hofbauer, Christina Guttmann-Gruber
Summary: Conventional anti-cancer therapies lack tumor specificity and can result in iatrogenic effects. Spliceosome-mediated RNA trans-splicing (SMaRT) is a promising approach that can target tumor cells while sparing normal cells. This study demonstrates the potential of SMaRT using the RNA trans-splicing molecule RTM44 to target the cancer gene Ct-SLCO1B3 in aggressive skin cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Narayan Bashyal, Tae-Young Lee, Da-Young Chang, Jin-Hwa Jung, Min Gyeong Kim, Rakshya Acharya, Sung-Soo Kim, Il-Hoan Oh, Haeyoung Suh-Kim
Summary: Research has shown that MSC-TK(A168H) cells modified with the HSV-TK(A168H) gene exhibit safety in pre-clinical trials, making them suitable for therapeutic use. This genetic modification makes allogeneic MSC-based ex vivo therapy safer by eliminating transplanted cells during SAEs such as uncontrolled cell proliferation.
MOLECULES AND CELLS
(2022)
Article
Chemistry, Physical
Neha Chaudhary, Anil Kumar Nain
Summary: This study measured the physicochemical properties of binary mixtures of PEG 200 with benzyl methacrylate and calculated the corresponding excess properties and molecular volumes. The results provide insights into the intermolecular interactions and the effects of composition and temperature on the physicochemical properties of these mixtures.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Medicinal
Houren Zhou, Hui Liu, Yue Zhang, Ying Xin, Chi Huang, Mingzhong Li, Xiaoyun Zhao, Pingtian Ding, Zhijun Liu
Summary: This study developed a nano-ultrasound contrast agent targeted at gastric tumors, which effectively improved the transfection efficiency of suicide genes in gastric cancer cells and induced significant apoptosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Soniya Peter, Manju Maria Mathews, Fels Saju, Swapna Paul
Summary: The purpose of this study was to optimize, formulate, and characterize Eudragit-based nanosuspension of Ganciclovir (GCV-NPs) as a carrier for ocular drug delivery. The formulated GCV-NPs showed advantages such as suitable pH, enhanced permeation, and sustained release of medication, indicating their potential role in ocular drug delivery.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Pharmacology & Pharmacy
Mehmet Hakan Taskin, Hanne Nur Kurucay, Hamza Kadi, Cuneyt Tamer, Emre Ozan, Bahadir Muftuoglu, Harun Albayrak, Semra Gumusova, Mahir Igde, Ahmed Eisa Elhag, Zafer Yazici
Summary: Two pandemics in the first two decades of the 21st century have highlighted the lack of effective antivirals against viruses with epidemic and pandemic potentials. This study investigated the antiviral effects of the base analogue 5-fluorouracil (FU) on herpes simplex virus type 1 (HSV-1) replication and identified drug resistance mutations.
Article
Green & Sustainable Science & Technology
Angus Shiue, Ming-Jie Yin, Min-Hsuan Tsai, Shu-Mei Chang, Graham Leggett
Summary: By casting a composite membrane on a reverse osmosis membrane in this study, the permeability and selectivity of CO2 were improved. The selection of materials and crosslinking agent enhanced the membrane performance and increased the separation efficiency of CO2.
Article
Thermodynamics
Ya-Fong Chung, Tsui-Ju Ku, Ardila Hayu Tiwikrama, Ming-Jer Lee
Summary: Densities of binary mixtures of PEGOPE + anisole or benzyl alcohol were experimentally determined at various temperatures and pressures. The excess volumes in these binary systems were found to be negative, indicating the dominance of hydrogen bonding. The Redlich-Kister equation was able to accurately correlate the isothermal and isobaric excess volumes. The Schotte and Flory-Orwoll-Vrij equations of state showed good agreement with the specific volumes of the pure components and mixtures, with average absolute relative deviations (AARDs) below 0.03%.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2023)
