Review
Materials Science, Multidisciplinary
Ernesto Paruli, Olivier Soppera, Karsten Haupt, Carlo Gonzato
Summary: Molecularly imprinted polymers (MIPs) have become highly attractive materials for biomimetic molecular recognition due to their excellent affinity and specificity, as well as their robustness and competitive costs. Control over size, morphology, and physical form of MIPs has led to defined micro- and nanostructures, crucial for modern applications. Light as a stimulus for structuring MIPs has emerged as a powerful tool, offering new possibilities for their development and application.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Analytical
Dominik Korol, Anna Kisiel, Maciej Cieplak, Agata Michalska, Piyush Sindhu Sharma, Krzysztof Maksymiuk
Summary: Electrochemically active molecularly imprinted polypyrrole nanoparticles (PPy NPs) were synthesized using micelles. The NPs with estriol imprinting were prepared by polymerizing pyrrole with the aid of iron(III) p-toluenesulfonate. SEM and TEM confirmed the synthesis of imprinted PPy NPs around 60 nm in size. The NPs prepared with pristine pyrrole showed an imprinting factor of 4.2, while those prepared with derivatized pyrrole showed no imprinting. The electrochemical-based transduction allowed for the determination of estriol in a concentration range of 0.5-5 μM and 10-100 μM, with a limit of detection (LOD) of 0.16 μM. The MIP NP-coated electrode exhibited satisfactory selectivity towards estriol and its structural analogs.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Dinh-Hai-Ngan Nguyen, Quang-Hai Le, Tuan-Linh Nguyen, Van-Tuan Dinh, Hoai-Nam Nguyen, Hong -Nam Pham, Tien-Anh Nguyen, Luong-Lam Nguyen, Thi-Mai-Thanh Dinh, Van-Quynh Nguyen
Summary: This work presents the development and application of micropatterned molecular imprinting in a conductive polymer film for the detection of diclofenac molecules. The technique involves combining nanosphere lithography and electrochemical polymerization to generate a nanos-tructured polymer on a glassy carbon electrode. The resulting molecularly imprinted polymer electrode shows good recognition properties for diclofenac molecules in phosphate-buffered saline solution, with increased sensitivity and a lower limit of detection compared to a non-molecular imprinted polymer electrode.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Patrycja Lach, Alvaro Garcia-Cruz, Francesco Canfarotta, Alistair Groves, Jakub Kalecki, Dominik Korol, Pawel Borowicz, Kostiantyn Nikiforow, Maciej Cieplak, Wlodzimierz Kutner, Sergey A. Piletsky, Piyush Sindhu Sharma
Summary: Redox-active MIP-Gly NPs were developed by incorporating ferrocenylmethyl methacrylate into the synthesis process, enabling them to selectively determine glyphosate without the need for redox probe. MIP-Gly NPs synthesized using allylamine and squaramide-based monomers exhibited the highest selectivity. The MIP-Gly NPs modified Pt-SPEs were characterized using differential pulse voltammetry and electrochemical impedance spectroscopy, with changes in the oxidation peak of the ferrocenyl moieties serving as the analytical signal. The chemosensor showed a low limit of detection and a wide linear dynamic concentration range for glyphosate, allowing successful detection in spiked river water samples.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Ying Xing, Xin Ding, Xilin Liang, Guangyan Liu, Shili Hou, Shifeng Hou
Summary: A novel magnetic Ti3C2Tx-MXene/Fe3O4 composite with excellent conductivity and large specific area was prepared. It exhibited an improved electron transfer rate and amplification of the sensor's signal. An ultrasensitive molecularly imprinted electrochemical sensor based on MXene/Fe3O4 composites was fabricated for detecting methylmalonic acid (MMA) with high selectivity. The sensor showed a good linear relationship with the logarithm of MMA concentration and a low detection limit, making it suitable for trace detection of organic carboxylic acid.
Article
Chemistry, Analytical
S. Irem Kaya, Ahmet Cetinkaya, Esen Bellur Atici, M. Emin Corman, Lokman Uzun, Sibel A. Ozkan
Summary: This study reports the fabrication of a highly sensitive electrochemical sensor using metal ion-assisted molecularly imprinted polymer for the determination of aclidinium bromide. The sensor showed high sensitivity and accuracy in detecting ACL in standard solution, serum sample, and capsule dosage form. This is the first study to report the electrochemical determination of ACL.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Pachanuporn Sunon, Kamonwad Ngamchuea
Summary: A highly sensitive and rapid electrochemical sensor was developed using a molecularly imprinted polymer (MIP) for detecting melatonin. The MIP was synthesized through electropolymerization without the need for an initiating reagent. The sensor exhibited good selectivity for melatonin and showed excellent reproducibility and repeatability. It was successfully applied for detecting melatonin in urine and saliva samples with high recoveries.
Article
Chemistry, Analytical
Fatma Budak, Ahmet Cetinkaya, S. Irem Kaya, Esen Bellur Atici, Sibel A. A. Ozkan
Summary: In this study, a molecularly imprinted polymer (MIP)-based sensor was developed for the electrochemical determination of Tofacitinib citrate (TOF). The sensor exhibited high selectivity, as confirmed by imprinting factor and interference studies. The sensor's performance was characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. Differential pulse voltammetry and electrochemical impedance spectroscopy methods were used for TOF determination, with low limit of detection and limit of quantification values. Recovery analysis with spiked serum and tablet samples validated the accuracy and applicability of the sensor.
Article
Chemistry, Physical
Zhaokun Yang, Huajun Jin, Ang Yu, Zhangyong Yu, Dongjian Shi, Shengrong Yan, Liyan Qin, Shirong Liu, Mingqing Chen
Summary: In comparison with molecularly imprinted photonic hydrogel, surface molecularly imprinted photonic hydrogel is more competitive as a molecular sensor due to presence of molecular recognition sites on its surface. However, the construction of surface molecularly imprinted photonic hydrogel sensors is still challenging. In this study, we report the construction of such sensors using poly (styrene-acrylic acid) colloids with carboxyl groups, which can readily bind imprinted molecules through hydrogen interaction. The constructed sensors exhibit high sensitivity, rapid response speed, and good selectivity, and show good sensing performance even in commercial milk.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Sangheon Jeon, Rowoon Park, Jeonghwa Jeong, Gyeonghwa Heo, Jihye Lee, Min Chan Shin, Young Woo Kwon, Jin Chul Yang, Woon Ik Park, Ki Su Kim, Jinyoung Park, Suck Won Hong
Summary: The study demonstrates a strategy that integrates nanoimprint technology with molecularly imprinted polymers, enabling efficient pattern transfer on fabric substrates and serving as a self-encoded filtration medium for selective separation of harmful substances, paving the way for designing next-generation separation systems.
Article
Materials Science, Multidisciplinary
Pau Molet, Nicolas Passarelli, Luis A. Perez, Leonardo Scarabelli, Agustin Mihi
Summary: Ordered arrays of metal nanoparticles can generate surface lattice resonances with higher quality factors, showing great potential for engineering light-matter interactions. The internal architecture of gold-nanoparticle meta-molecules influences the optical response of plasmonic supercrystals.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Chemistry, Analytical
M. Emin corman, Ahmet Cetinkaya, Goksu Ozcelikay, Erdogan Ozgur, Esen B. Atici, Lokman Uzun, Sibel A. Ozkan
Summary: A novel methodology was used to generate a porous molecularly imprinted material for highly selective and sensitive recognition of the Janus kinase inhibitor ruxolitinib (RUX). The porous MIP modified glassy carbon electrode linearly responded to RUX concentration up to 0.01 pM with a limit of detection of 0.00191 pM under optimized conditions. This method improves the accessibility of binding sites by generating porous material, resulting in highly selective and sensitive recognition of drugs in pharmaceutical dosage form and synthetic human serum samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
M. Emin corman, Ahmet Cetinkaya, Canan Armutcu, Esen Bellur Atici, Lokman Uzun, Sibel A. Ozkan
Summary: In this study, pyrrole-histidine has been used as a novel functional monomer to fabricate a molecularly imprinted electrochemical sensor for the selective and sensitive detection of teriflunomide (TER). The developed sensor showed a linear response to TER with low detection limit, and demonstrated excellent recovery rates in synthetic serum samples and tablet dosage form.
Article
Chemistry, Physical
Wei Chen, Zhiyang Guo, Hao Yu, Qingyun Liu, Min Fu
Summary: Glycoproteins are important biomarkers in living organisms, but selective detection remains a challenge due to low content in biological fluids. A molecularly imprinted colloidal array with multi-boronic acid sites was proposed for glycoprotein detection, showing promising results in terms of adsorption capacity and selectivity. The label-free optical sensor constructed from this array demonstrated the potential for naked-eye detection of glycoprotein, with successful detection from human serum samples.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Ani Mulyasuryani, Yuniar Ponco Prananto, Qonitah Fardiyah, Hanandayu Widwiastuti, Darjito Darjito
Summary: Molecularly Imprinted Polymers (MIPs) modified screen-printed carbon electrode (SPCE) was developed for the determination of p-aminophenol (p-AP). The MIP was prepared using p-AP as a template, chitosan as a base polymer, and glutaraldehyde and sodium tripolyphosphate as crosslinkers. The results showed that the MIP selectively accumulated analytes on the electrode surface, and MIP with glutaraldehyde as a crosslinker increased the signal.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)