Journal
NANO LETTERS
Volume 12, Issue 12, Pages 6453-6458Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl3039162
Keywords
DNA bundles direct imaging; transmission electron microscopy; superhydrophobic surface; nanofabricated micropillars; molecular dynamics simulations
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Funding
- European Project [SMD FP7-NMP 2800-SMALL-2, CP-FP 229375-2]
- Single Molecule Activation and Computing (FOCUS) project under seventh Framework Programme [270483]
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Direct imaging becomes important when the knowledge at few/single molecule level is requested and where the diffraction does not allow to get structural and functional information. Here we report on the direct imaging of double stranded (ds) lambda-DNA in the A conformation, obtained by combining a novel sample preparation method based on super hydrophobic DNA molecules self-aggregation process with transmission electron microscopy (TEM). The experimental breakthrough is the production of robust and highly ordered paired DNA nanofibers that allowed its direct TEM imaging and the double helix structure revealing.
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