Review
Chemistry, Multidisciplinary
Jie Zhang, Lin Zhang, Zhishang Li, Qi Zhang, Yanbin Li, Yibin Ying, Yingchun Fu
Summary: This review evaluates two main types of nanoconfinement systems - confined nanochannels and planes - and summarizes the nanoconfinement effect mechanisms and applications in electrochemical analysis and sensing. It aims to help researchers deepen their understanding of nanoconfinement devices and their effects, in order to develop new analysis and sensing applications in various fields.
Article
Nanoscience & Nanotechnology
Xinyue Ma, Yue Li, Jie Zhang, Tongtong Ma, Lin Zhang, Yi Chen, Yibin Ying, Yingchun Fu
Summary: An integrated nanochannel electrode (INCE) with nanoporous gold layers was fabricated and used for small-molecule analysis. Metal-organic frameworks (MOFs) were decorated inside and outside of the nanochannels to capture small molecules and generate current signals. This study provides a new approach for nanopore analysis of small molecules by utilizing the outer surface and internal nanoconfined space of nanochannels.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Qi Rao, Yidong Xia, Jiaoyan Li, Milind Deo, Zhen Li
Summary: The study on hydrocarbon liquid flow in amorphous silica cylindrical nanochannels revealed the presence of a strong threshold effect, nanoconfinement effect, and shear-thinning phenomenon. Additionally, the study discovered phenomena that differ from nanochannel flow of liquid water and gas in literature.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Bingchen Che, Dan Sun, Chen Zhang, Jiaqing Hou, Wei Zhao, Guangyin Jing, Yuguang Mu, Yaoyu Cao, Liang Dai, Ce Zhang
Summary: Mechanically induced chromosome reorganization is important in transcriptional regulation, but the interplay between chromosome reorganization and transcription activities is complicated. By introducing DNA, packaging proteins, and transcription factor NF-KB into a fluidic chip with varying spatial confinement, it was found that strong nanoconfinement suppresses higher-order folding of protein-DNA complexes and leads to increased NF-KB binding. Overall, these results reveal a pathway of how intranuclear geometrical cues alter the open/closed state of a DNA-protein complex and affect transcription activities.
Article
Engineering, Chemical
Seung Eun Lee, Kyoung-Yong Chun, Jongwoon Kim, Sunghwan Jo, Chang -Soo Han
Summary: The fabrication of advanced membranes with simultaneously high electron and proton conductivities has been achieved through the thermal reduction and vertical confinement of graphene oxide (GO) channels. The improvement in electron conductivity is due to the removal of oxygen functional groups, while the extremely reduced channel size allows for selective proton transport and improved proton selectivity.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Johanna Wordsworth, Tania M. Benedetti, Samuel V. Somerville, Wolfgang Schuhmann, Richard D. Tilley, J. Justin Gooding
Summary: This review focuses on the impact of nanoparticles and nanostructured electrodes on electrocatalytic reactions, specifically in terms of activity and selectivity. The authors also discuss the fundamental understanding of how electrochemistry and electrocatalysis are influenced by nanoconfinement. It is emphasized that nanostructuring can break the scaling relations imposed on electrocatalysis by thermodynamics, going beyond just increasing surface area.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Chemical
Jin Wang, Sensen Liu, Shuchang Zheng, Shangzhen Li, Di Wang, Miaolu He, Lei Wang, Xudong Wang
Summary: The exceptional ion release and storage ability of biological ion channels have attracted significant attention for various life activities. This study presented the ion transport behavior in a vertically-oriented three-sectional Ti3C2Tx membrane with asymmetric charge distribution. By grafting silane molecules onto the surface, the surface charge polarity of the Ti3C2Tx nanosheet was changed, leading to a diode-like ion transport property in the heterogenous membrane. Numerical simulations based on PNP equations showed that the directional ion diffusion was attributed to ion accumulation and depletion in the nanochannels under different potential biases. The heterogenous membrane also showed potential in desalination and ion storage applications.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Lei Liu, Menghe Zhu, Xiaodong Xu, Xin Li, Zhewen Ma, Zhen Jiang, Andrij Pich, Hao Wang, Pingan Song
Summary: The concept of dynamic hydrogen-bonded nanoconfinement is proposed for the first time, leading to the successful design of highly stretchable and supratough biocompatible PVA. This work opens up new opportunities for creating mechanically robust, healable, and biocompatible polymeric materials.
ADVANCED MATERIALS
(2021)
Article
Polymer Science
Chenghong Huang, Hong Tang, Xiaorong Huang, Hongjie Chen, Kang Yang, Qi Yin, Lin Zhang, Xia Li, Xue Mou, Shuangkou Chen, Yuchan Zhang, Yan Hu
Summary: This study demonstrated that ethyl vanillin can be quickly crystallized from carboxymethyl chitosan/ethyl vanillin co-mixture gels via classical swift cooling method and supersaturation. EVA appeared with bulk filament crystals accelerated by a large quantity of nanoconfinement microregions resulted from space-formatted hydrogen network between EVA and CMCS when their concentration exceeds 1:1.4 and may occasionally arise when the concentration is less than 1:0.8。Further investigations found that EVA crystals can be recovered from as-prepared ion-switchable CMCS gels by 0.1 M hydrochloric acid or acetic acid without defects. Consequently, the proposed method may offer an available scheme for a large-scale preparation of API analogs.
Article
Chemistry, Multidisciplinary
Ming Cheng, Fei Zhu, Siyun Zhang, Xingrou Zhang, Manivannan Kalavathi Dhinakaran, Haibing Li
Summary: By designing and constructing a novel nanochannel inspired by chloride channel protein, which has Cl- selectivity and can improve Cl- transport flux by adjusting the asymmetric degree, a high flux artificial ion channel has been successfully constructed for practical applications like microfluidic devices, sensors, and ion separation.
Article
Chemistry, Physical
Pei Bai, Mingchao Ma, Li Sui, Yunlong Guo
Summary: This study demonstrates significant changes in stiffness and the ratio between elastic and viscous responses in thin PDMS films under nanoconfinement, with an enhanced elastic modulus and increased viscous response observed. The results contribute to a better understanding of the nanoconfinement effect on viscoelastic properties of soft matter.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Thermodynamics
Kecheng Zeng, Peixue Jiang, Ruina Xu
Summary: In this study, a workflow was proposed to reconstruct amorphous shale organic nanopores, detect effective pore size, and calculate the self-diffusion coefficient of nanoconfined CO 2 /CH 4 using the grand canonical Monte Carlo (GCMC) method and molecular dynamics (MD) simulations. The effects of temperature, pressure, and pore size were considered, and a nondimensional self-diffusion coefficient and correlation formula were derived. The strong interaction between CO 2 and the pore surface reduced the self-diffusion coefficient of the binary mixture CO 2 /CH 4 . The derived workflow, nondimensional self-diffusion coefficient, and correlation formula can be applied to catalyst, fuel cell, and sewage treatment systems.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Multidisciplinary Sciences
Ryan A. Herold, Raphael Reinbold, Christopher J. Schofield, Fraser A. Armstrong
Summary: Electrochemical studies reveal that nanoconfinement significantly increases the efficiency of enzyme-catalyzed cascade reactions. By using a nanoporous conducting indium tin oxide film and entrapping Isocitrate dehydrogenase 1 (IDH1), the complete electrochemical oxidation of isocitrate to 2-oxoglutarate is achieved using only the NADP(H) cofactor carried into the electrode pores. The results demonstrate the power of nanoconfinement in facilitating multistep enzyme catalysis and provide insights into the role of nicotinamide cofactors as redox carriers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Materials Science, Multidisciplinary
Yuan Gao, Mingzhe Li, Haozhe Zhang, Yue Zhang, Weiyi Lu, Baoxing Xu
Summary: This study investigates the outflow behavior of confined water in hydrophobic nanopores and reveals its solid-like necking phenomenon and rupture. Molecular dynamics simulations demonstrate that this behavior is attributed to strong interactions between water molecules and the nanoporous confinements. The scaling laws of outflow deformation and strength are quantitatively described and confirmed by experiments, providing a new approach for investigating the mechanical and structural properties of nanoconfined liquid.
Article
Nanoscience & Nanotechnology
Qiwen Lai, Chulaluck Pratthana, Yuwei Yang, Aditya Rawal, Kondo-Francois Aguey-Zinsou
Summary: The thermodynamic behavior of complex borohydrides confined in mesoporous hollow carbon spheres was investigated, showing no variation of equilibrium plateau pressure upon changes in the hydrogen sorption temperatures. This is interpreted as a result of the high pressure within the carbon nanopores, providing a means to control the thermodynamics of nanosized hydrides.
ACS APPLIED NANO MATERIALS
(2021)
Article
Oncology
C. S. Grasso, A. K. Cani, D. H. Hovelson, M. J. Quist, N. J. Douville, V. Yadati, A. M. Amin, P. S. Nelson, B. L. Betz, C-J. Liu, K. E. Knudsen, K. A. Cooney, F. Y. Feng, A. S. McDaniel, S. A. Tomlins
ANNALS OF ONCOLOGY
(2015)
Article
Engineering, Biomedical
Jack D. Wang, Nicholas J. Douville, Shuichi Takayama, Mohamed ElSayed
ANNALS OF BIOMEDICAL ENGINEERING
(2012)
Review
Otorhinolaryngology
Nicholas J. Douville, Carol R. Bradford
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2013)
Article
Materials Science, Multidisciplinary
M. D. Thouless, Z. Li, N. J. Douville, S. Takayama
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2011)
Article
Anesthesiology
Nicholas J. Douville, Elizabeth S. Jewell, Neal Duggal, Ross Blank, Sachin Kheterpal, Milo C. Engoren, Michael R. Mathis
ANESTHESIA AND ANALGESIA
(2020)
Article
Cardiac & Cardiovascular Systems
Brooke N. Wolford, Whitney E. Hornsby, Dongchuan Guo, Wei Zhou, Maoxuan Lin, Linda Farhat, Jennifer McNamara, Anisa Driscoll, Xiaoting Wu, Ellen M. Schmidt, Elizabeth L. Norton, Michael R. Mathis, Santhi K. Ganesh, Nicholas J. Douville, Chad M. Brummett, Jacob Kitzman, Y. Eugene Chen, Karen Kim, G. Michael Deeb, Himanshu Patel, Kim A. Eagle, Dianna M. Milewicz, Cristen J. Willer, Bo Yang
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2019)
Article
Anesthesiology
Michael R. Mathis, Neal M. Duggal, Donald S. Likosky, Jonathan W. Haft, Nicholas J. Douville, Michelle T. Vaughn, Michael D. Maile, Randal S. Blank, Douglas A. Colquhoun, Raymond J. Strobel, Allison M. Janda, Min Zhang, Sachin Kheterpal, Milo C. Engoren
Article
Anesthesiology
Michael R. Mathis, Milo C. Engoren, Hyeon Joo, Michael D. Maile, Keith D. Aaronson, Michael L. Burns, Michael W. Sjoding, Nicholas J. Douville, Allison M. Janda, Yaokun Hu, Kayvan Najarian, Sachin Kheterpal
ANESTHESIA AND ANALGESIA
(2020)
Article
Cardiac & Cardiovascular Systems
Nicholas J. Douville, Ida Surakka, Aleda Leis, Christopher B. Douville, Whitney E. Hornsby, Chad M. Brummett, Sachin Kheterpal, Cristen J. Willer, Milo Engoren, Michael R. Mathis
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2020)
Article
Anesthesiology
Nicholas J. Douville, Sachin Kheterpal, Milo Engoren, Michael Mathis, George A. Mashour, Whitney E. Hornsby, Cristen J. Willer, Christopher B. Douville
BRITISH JOURNAL OF ANAESTHESIA
(2020)
Article
Anesthesiology
Nicholas J. Douville, Christopher B. Douville, Graciela Mentz, Michael R. Mathis, Carlo Pancaro, Kevin K. Tremper, Milo Engoren
Summary: This study leveraged machine learning techniques to predict the need for mechanical ventilation in COVID-19 patients, identifying key vital sign predictors such as SpO(2)/FiO(2) ratio, ventilatory frequency, and heart rate. The model demonstrated good discrimination, helping to identify high-risk patients and provide insight into accompanying symptoms of respiratory failure in COVID-19.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Hematology
Nicholas J. Douville, Ryan Davis, Elizabeth Jewell, Douglas A. Colquhoun, Satya Krishna Ramachandran, Milo C. Engoren, Paul Picton
Summary: Large volume intraoperative transfusion is associated with hypocalcaemia, but not with adverse clinical outcomes in surgical patients.
TRANSFUSION MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Rachel J. Berkowitz, Milo C. Engoren, Graciela Mentz, Pratima Sharma, Sathish S. Kumar, Ryan Davis, Sachin Kheterpal, Christopher J. Sonnenday, Nicholas J. Douville
Summary: This study examined the impact of intraoperative management on the risk of acute kidney injury following liver transplantation. The results identified several preoperative and intraoperative variables associated with posttransplant acute kidney injury.
LIVER TRANSPLANTATION
(2022)
Letter
Gastroenterology & Hepatology
Rachel J. Berkowitz, Milo C. Engoren, Graciela Mentz, Pratima Sharma, Sathish S. Kumar, Ryan Davis, Sachin Kheterpal, Christopher J. Sonnenday, Nicholas J. Douville
LIVER TRANSPLANTATION
(2022)
