Article
Chemistry, Multidisciplinary
Ingo Helmers, Muhammad Saddam Hossain, Nils Baumer, Paul Wesarg, Bartolome Soberats, Linda S. Shimizu, Gustavo Fernandez
Summary: By enforcing an anti-cooperative self-assembly, we have achieved a maintained emissive behavior in the self-assembled state and limited the growth of the assembly. This research finding is significant for the study of emissive supramolecular assemblies and controlled supramolecular polymerization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Medicinal
Fengjuan Huang, Ying Wang, Yu Zhang, Chuang Wang, Jiangfang Lian, Feng Ding, Yunxiang Sun
Summary: The pathological aggregation of α-synuclein into amyloid fibrils is characteristic of Parkinson's disease. Repeats R3 and R6 play a crucial role in α-synuclein's aggregation, as they readily self-assemble into β-sheet-rich oligomers. R6 acts as the primary amyloidogenic core buried inside the central β-core, attracting neighboring repeats to form β-sheets, while R3 serves as a secondary amyloidogenic core, forming independent β-sheets in the fibril. These findings highlight the significance of R3 and R6 repeats in α-synuclein's amyloid aggregation and suggest their potential as targets for amyloid inhibitors.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Multidisciplinary
Juby K. Ajish, K. S. Ajish Kumar
Summary: A sugar based acrylamide was synthesized and found to exhibit fractal-like self-assembly behavior. The material showed specificity to lectin RCA120 and potential applications in drug delivery and tissue engineering. The study provides insights into the design of fractal glycomaterials.
Article
Multidisciplinary Sciences
Shengkai Li, Bahnisikha Dutta, Sarah Cannon, Joshua J. Daymude, Ram Avinery, Enes Aydin, Andrea W. Richa, Daniel Goldman, Dana Randall
Summary: This study introduces a method for controlling robotic swarms at macro and micro scales through theoretical abstraction and experimental systems, exploring collective behaviors guided by physical interactions. The research shows that increasing interparticle attraction can lead to a transition from dispersed to compact phase, enabling the collective to perform emergent tasks.
Article
Chemistry, Multidisciplinary
Dor Zaguri, Manuela R. Zimmermann, Georg Meisl, Aviad Levin, Sigal Rencus-Lazar, Tuomas P. J. Knowles, Ehud Gazit
Summary: The study found that the aggregation propensity of three phenylalanine-containing molecules increases significantly with size, with triphenylalanine being the most aggregation-prone species under experimental conditions. In the context of classical nucleation theory, this increase in aggregation propensity is attributed to the larger free energy decrease upon aggregation of larger peptides, and not to the presence/absence of a peptide bond per se. This work provides insights into the aggregation processes of chemically simple systems and suggests that both backbone-containing peptides and backbone-lacking amino acids assemble through a similar mechanism, supporting the classification of amino acids in the continuum of amyloid-forming building blocks.
Article
Chemistry, Multidisciplinary
Ying He, Mengjia Liu, Shun Teng, Lukasz Wojtas, Guangxin Gu, Xiaodong Shi
Summary: Fluorescence active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G(8)-quadruplexes. This study provided the first direct evidence on the self-assembled G-quadruplex fluorescence emission with aggregation-induced emission (AIE), which could be used as a foundation for designing FL molecular probes for G-quadruplex recognition.
CHINESE CHEMICAL LETTERS
(2022)
Article
Multidisciplinary Sciences
Adam J. Wargacki, Tobias P. Worner, Michiel van de Waterbeemd, Daniel Ellis, Albert J. R. Heck, Neil P. King
Summary: Recent advances in computational methods have enabled the predictive design of self-assembling protein nanomaterials with atomic-level accuracy. Investigation shows that the assembly of these materials is highly cooperative, providing a controllable route for the manufacture of designed protein nanomaterials.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Jindong Ren, Matthias Freitag, Yuxiang Gao, Peter Bellotti, Mowpriya Das, Bertram Schulze Lammers, Harry Monig, Yuyang Zhang, Constantin G. Daniliuc, Shixuan Du, Harald Fuchs, Frank Glorius
Summary: This study demonstrated the reversible self-assembly of cyclohexyl cyclic (alkyl)(amino)-carbenes and the importance of cyCAAC-surface interactions. By analyzing the molecular surface geometry and exploring various surfaces, the study deepened our understanding of cyCAAC binding mode and provided insights for catalysis, biosensor design, and surface functionalization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Mikiko Vazquez-Nakagawa, Laura Rodriguez-Perez, Nazario Martin, M. Angeles Herranz
Summary: This study describes a method for preparing new chiral graphene quantum dots through chemical functionalization, and examines their supramolecular assembly using microscopy. Fluorescence studies show that the fibers stem from the pi-pi stacking of pyrenes and GQDs, along with the hydrogen bonding interactions of the amide groups.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Siliang Cai, Junxian Chen, Sheng Wang, Jie Zhang, Xinhua Wan
Summary: The study investigated the allosterical nature of protein-mimicking polymers in self-assembly, finding that conformational transitions induced different structures during assembly, and the change in chirality influenced the formation of final helical strands.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Yu Zhu, P. B. Sunil Kumar, Mohamed Laradji
Summary: The conformational behavior and spatial organization of self-avoiding semi-flexible ring polymers adsorbed on solid substrates strongly depend on their bending stiffness and areal number density. The elongation of polymers increases with the areal number density and shows a non-monotonic dependence on the bending stiffness. Higher densities lead to self-assembly into liquid-crystalline phases, with different geometric shapes and ordered structures observed at various densities.
Article
Chemistry, Multidisciplinary
Jie Li, Jianyu Zhang, Jianxing Wang, Dong Wang, Yun Yan, Jianbin Huang, Ben Zhong Tang
Summary: Utilizing nonplanar conjugated molecules for self-assembly is challenging but important. In this study, the self-assembly process of a nonplanar conjugated molecule with aggregation-induced emission (ALE) feature was demonstrated, driven by amphiphiles. The superhigh aggregation-sensitive emission provided precise information about the self-assembly process. The arrangements of ALE-active molecules changed from disordered to well-organized forms by reducing the twisted configuration. The obtained vesicles showed superhigh thermal stability and promising light-harvesting applications.
Article
Chemistry, Multidisciplinary
Xiujuan Shi, Jun Zhang, Junkai Liu, Xueqian Zhao, Haoran Wang, Peifa Wei, Xiaodong Zhang, Xin-Long Ni, Herman H-Y Sung, Ian D. Williams, Wai Kit Ng, Kam Sing Wong, Jacky W. Y. Lam, Lin Wang, Honglin Jin, Ben Zhong Tang
Summary: In this study, a hierarchical supramolecular self-assembly method was proposed for the fabrication of fluorescent multiblock microcolumns containing 1 to 7 blocks using CB[8], NaBr, and AIEgen guests.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Weixi Jiang, Chen Cheng, Xiaoling Qiu, Li Chen, Xun Guo, Yuanli Luo, Jingxue Wang, Junrui Wang, Zhuoyan Xie, Pan Li, Zhigang Wang, Haitao Ran, Zhiyi Zhou, Jianli Ren
Summary: The emergence of aggregation-induced emission luminogens (AIEgens) has attracted scientific attention, but their antitumor efficacy in photodynamic therapy (PDT) is limited due to poor water solubility and treatment depth. Therefore, a new AIEgens-involved therapeutic platform with good permeability and bioavailability is urgently needed. In this study, supramolecular chemistry is combined with the AIEgen bis-pyrene (BP) to construct a peptide-AIEgen hybrid nanosystem (PAHN) that can improve hydrophilicity and achieve stratified targeting for efficient therapy.
Article
Physics, Fluids & Plasmas
Anurag Singh, Suparna Khatun, Nisha Pawar, Amar Nath Gupta
Summary: Experimental evidence shows that the aggregation of amyloid n (An) under diffusion-limited conditions leads to fractal self-assembly, mediated by electrostatic and hydrophobic patches on the surface of An oligomers. Laser light scattering experiments revealed a morphological phase transition in the fractal structures, modulated by electrostatic interactions with the solution's pH. The high surface-to-volume ratio of these fractal self-assemblies may have applications in drug delivery, biosensing, and other biomedical fields.
