Journal
MYCOSES
Volume 61, Issue 11, Pages 796-813Publisher
WILEY
DOI: 10.1111/myc.12838
Keywords
cancer; diagnosis; fungal infections; granulocytopenia; haematology; recommendations
Categories
Funding
- Astellas Pharma Funding Source: Medline
- Gilead Sciences Funding Source: Medline
- Pfizer Funding Source: Medline
- Schering-Plough Funding Source: Medline
- Bio-Rad Funding Source: Medline
- MSD Funding Source: Medline
- MSD Sharp & Dohme/Merck Funding Source: Medline
- German Federal Ministry of Research and Education [13GW0096D, 01EO1002] Funding Source: Medline
Ask authors/readers for more resources
Invasive fungal diseases (IFD) are a primary cause of morbidity and mortality in patients with haematological malignancies. These infections are mostly life-threatening and an early diagnosis and initiation of appropriate antifungal therapy are essential for the clinical outcome. Most commonly, Aspergillus and Candida species are involved. However, other Non-Aspergillus moulds are increasingly identified in case of documented IFD. For definite diagnosis of IFD, a combination of diagnostic tools have to be applied, including conventional mycological culture and non-conventional microbiological tests such as antibody/antigen and molecular tests, as well as histopathology and radiology. Although varying widely in cancer patients, the risk of invasive fungal infection is highest in those with allogeneic stem cell transplantation and those with acute leukaemia and markedly lower in patients with solid cancer. Since the last edition of Diagnosis of Invasive Fungal Diseases recommendations of the German Society for Hematology and Oncology in 2012, integrated care pathways have been proposed for the management and therapy of IFDs with either a diagnostic driven strategy as opposed to a clinical or empirical driven strategy. This update discusses the impact of this additional evidence and effective revisions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available