Journal
MYCOSES
Volume 57, Issue 7, Pages 442-447Publisher
WILEY
DOI: 10.1111/myc.12176
Keywords
Cryptococcus gattii; molecular type VGI; primary cutaneous cryptococcosis - PCC; immunocompetent patient; virulence factors; antifungal therapy
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
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Primary Cutaneous Cryptococcosis is an uncommon infection caused by the yeast Cryptococcus neoformans and C. gattii. Few case reports are available in the literature describing in detail primary cutaneous cryptococcosis due to C. gattii in immunocompetent patients. Herein, we present a case of a 68-year-old immunocompetent male patient with erythematous nodular lesions on the right forearm due to C. gattii mating-type a and molecular type VGI. The virulence factors test was performed for capsule diameter, melanin production and phospholipase activity. In vitro fluconazole testing showed the sensitivity profile of this clinical isolate. In addition, a review of the literature on this subject was carried out and verified that this is the first reported case of VGI in the south-east region of Brazil.
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